[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100570563":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":10,"centralContacts":26,"locations":10,"responsibleParty":32,"collaborators":10,"id":36,"slug":37,"hasResults":38,"nctId":39,"briefTitle":40,"officialTitle":41,"acronym":10,"eligibilityCriteria":42,"healthyVolunteers":38,"sex":43,"minAge":44,"maxAge":10,"enrollmentInfo":45,"targetDuration":10,"studyType":48,"phases":10,"briefSummary":49,"conditions":50,"keywords":10,"overallStatus":54,"whyStopped":10,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":59,"completionDateStruct":60,"leadSponsor":62,"locationsCount":10},{"fullName":5,"class":6},"Chinese PLA General Hospital","OTHER",[8,13],{"label":9,"type":10,"description":10,"interventionNames":11},"Therma ablation",null,[12],"Procedure: Thermal ablation",{"label":14,"type":10,"description":10,"interventionNames":15},"Parathyroidectomy",[16],"Procedure: Parathyroidectomy",[18,23],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"PROCEDURE","Thermal ablation","Thermal ablation is a minimally invasive procedure used to treat primary hyperparathyroidism, a condition where one or more of the parathyroid glands produce excessive amounts of parathyroid hormone (PTH). The treatment involves using heat to destroy the overactive parathyroid tissue. This can be done through various methods such as radiofrequency ablation (RFA) and microwave ablation(MWA).",[9],{"type":19,"name":14,"description":24,"armGroupLabels":25,"otherNames":10},"Parathyroidectomy is a surgical procedure to remove one or more of the parathyroid glands in cases of hyperparathyroidism.",[14],[27],{"name":28,"role":29,"phone":30,"phoneExt":10,"email":31},"Yang Liu","CONTACT","+8616601565730","yang2818025107@163.com",{"type":33,"investigatorFullName":34,"investigatorTitle":35,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Ping Liang","Professor","100570563","thermal-ablation-versus-parathyroidectomy-for-primary-hyperparathyroidism-100570563",false,"NCT06708871","Thermal Ablation Versus Parathyroidectomy for Primary Hyperparathyroidism","Thermal Ablation Versus Parathyroidectomy for Primary Hyperparathyroidism: a Multicenter Study","Inclusion Criteria:\n\n* Symptomatic patients with primary hyperparathyroidism, such as those with symptoms in any system including the kidneys, bones, gastrointestinal tract, psychoneurological system, or those with atypical symptoms such as muscle weakness, dysfunction, and sleep disorders.\n* Asymptomatic PHPT patients with any of the following conditions:\n\n  ① Serum calcium is higher than the upper limit of the normal value by 1 mg\u002FdL (0.25 mmol\u002FL);\n\n  ② There is objective evidence of renal involvement, including asymptomatic kidney stones, nephrocalcinosis, hypercalciuria (24 - hour urinary calcium level \\> 400 mg\u002FdL) on renal imaging, or impaired renal function (glomerular filtration rate \\\u003C 60 mL\u002Fmin);\n\n  ③ There is evidence of osteoporosis (bone mineral density decreased by 2.5 standard deviations at any site) and\u002For radiographic evidence of fragility fractures.\n\n  ④ Age \\\u003C 50 years\n\n  ⑤ The patient cannot accept routine follow - up observation.\n* Imaging examination shows that at least one parathyroid gland is enlarged.\n\nExclusion Criteria:\n\n* diagnosis of secondary or tertiary HPT\n* severe coagulation disorder\n* severe cardiopulmonary insufficiency","ALL","18 Years",{"count":46,"type":47},520,"ESTIMATED","OBSERVATIONAL","This study is a prospective, multicenter study designed to compare the efficacy and safety of surgical treatment versus ablation therapy (including radiofrequency ablation and microwave ablation) for patients with primary hyperparathyroidism (PHPT). The study will assess the impact of both treatment modalities on serum parathyroid hormone (iPTH) and calcium levels, clinical symptom improvement, bone mineral density enhancement, reduction in the incidence of urinary system stones, and postoperative complication rates. While surgical treatment has been the standard of care for PHPT, offering definitive cure, it carries inherent surgical risks and complications. Ablation therapy, as a minimally invasive approach, presents a novel alternative with reduced trauma and fewer complications. The outcomes of this study will inform clinical decision-making and potentially optimize treatment strategies for patients with PHPT.",[51,52,53],"Cure Rate","Complication Rate","Efficacy and Safety","NOT_YET_RECRUITING","2024-11-26",{"date":57,"type":58},"2024-11-27","ACTUAL",{"date":55,"type":47},{"date":61,"type":47},"2028-12-26",{"name":5,"class":6}]