[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100613806":3},{"organization":4,"armGroups":7,"interventions":36,"overallOfficials":46,"centralContacts":51,"locations":60,"responsibleParty":81,"collaborators":41,"id":83,"slug":84,"hasResults":85,"nctId":86,"briefTitle":87,"officialTitle":87,"acronym":41,"eligibilityCriteria":88,"healthyVolunteers":85,"sex":89,"minAge":90,"maxAge":91,"enrollmentInfo":92,"targetDuration":41,"studyType":95,"phases":96,"briefSummary":98,"conditions":99,"keywords":102,"overallStatus":63,"whyStopped":41,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":114},{"fullName":5,"class":6},"National Institutes of Health Clinical Center (CC)","NIH",[8,14,18,22,28,32],{"label":9,"type":10,"description":11,"interventionNames":12},"Common Airway","EXPERIMENTAL","Exposure to a sham air purifier, and wall art with foam and polyurethane.",[13],"Other: Environmental Exposures",{"label":15,"type":10,"description":16,"interventionNames":17},"Common Gastrointestinal","Exposure to an ultra processed diet.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Common Skin","Exposure to toothpaste, body wash, shampoo, and detergents containing sodium lauryl sulfate and other hazardous agents (commonly used likely toxic ingredients).",[13],{"label":23,"type":24,"description":25,"interventionNames":26},"Pure Airway","OTHER","Exposure to wall art without foam and polyurethane.",[27],"Other: Control Exposures",{"label":29,"type":24,"description":30,"interventionNames":31},"Pure Gastrointestinal","Exposure to a a minimally processed diet.",[27],{"label":33,"type":24,"description":34,"interventionNames":35},"Pure Skin","Exposure to SLS-free and toxin free toothpaste, body wash, shampoo, detergents, non-synthetic clothing, and sheets.",[27],[37,42],{"type":24,"name":38,"description":39,"armGroupLabels":40,"otherNames":41},"Environmental Exposures","Toothpaste, skin lotion, hand soap, body wash, laundry detergent, shampoo containing sodium lauryl sulfate (SLS), wall art with foam and polyurethane, and processed food.",[9,15,19],null,{"type":24,"name":43,"description":44,"armGroupLabels":45,"otherNames":41},"Control Exposures","SLS-free, toxin free toothpaste, body wash, shampoo, detergents, non-synthetic clothing, and sheets, a minimally processed diet, and wall art without foam and polyurethane.",[23,29,33],[47],{"name":48,"affiliation":49,"role":50},"Hirsh D Komarow, M.D.","National Institute of Allergy and Infectious Diseases (NIAID)","PRINCIPAL_INVESTIGATOR",[52,57],{"name":53,"role":54,"phone":55,"phoneExt":41,"email":56},"Jodi L Blake, R.N.","CONTACT","(301) 605-2896","jodi.blake@nih.gov",{"name":48,"role":54,"phone":58,"phoneExt":41,"email":59},"(301) 594-2197","komarowh@mail.nih.gov",[61],{"facility":62,"status":63,"city":64,"state":65,"zip":66,"country":67,"countryCode":68,"cosmosGeoPoint":69,"geoPoint":74,"contacts":75},"National Institutes of Health Clinical Center","RECRUITING","Bethesda","Maryland","20892","United States","US",{"type":70,"coordinates":71},"Point",[72,73],-77.10026,38.98067,{"lat":73,"lon":72},[76,79],{"name":77,"role":54,"phone":78,"phoneExt":41,"email":56},"Jodi Blake","301-605-2896",{"name":80,"role":54,"phone":58,"phoneExt":41,"email":59},"Komarow Hirsh",{"type":82,"investigatorFullName":41,"investigatorTitle":41,"investigatorAffiliation":41,"oldNameTitle":41,"oldOrganization":41},"SPONSOR","100613806","threat-testing-harms-related-to-exposure-to-allergenic-and-epithelial-toxins-100613806",false,"NCT07271381","THREAT: Testing Harms Related to Exposure to Allergenic and Epithelial Toxins","* INCLUSION CRITERIA:\n\nTo participate in this study, an individual must meet all of the following criteria:\n\n1. Ability to provide informed consent.\n2. Age 18-80 years.\n3. Agreement to adhere to lifestyle considerations.\n4. Ability to exclusively adhere to UPD and MPD during inpatient stay.\n5. Ability to speak English.\n6. Willing to allow storage of samples and data for future research.\n\nEXCLUSION CRITERIA:\n\nAn individual who meets any of the following criteria will be excluded from participation in this study:\n\n1. Diagnosis of atopic (physician-diagnosed asthma, AD, food allergy, chronic hives), autoimmune, metabolic, or chronic infectious or inflammatory diseases.\n2. Current or history of neoplastic disease within 5 years.\n3. Use of medication(s) that may affect skin, GI, and\u002For airway symptoms and may have an effect on skin microbiome, GI microbiome (topical or oral antibiotic use may require 3-6 month delay in enrollment for gut microbiome repopulation, see #8), and\u002For serum cytokines (other than oral birth control, which is not exclusionary and is allowed during participation provided there is consistence use for 3-6 months prior to enrollment).\n4. Current receipt of chemotherapy.\n5. HIV, hepatitis B, or hepatitis C infection.\n6. Receipt of any vaccine within 1 month prior to enrollment.\n7. Receipt of oral antibiotics within 3-6 months prior to enrollment.\n8. Use of topical, oral, or parental corticosteroids within 1 month prior to enrollment.\n9. Participation in another treatment or intervention study within 3 months prior to enrollment.\n10. Currently pregnant or lactating.\n11. Currently smoking or vaping.\n12. Any other condition or intercurrent illness deemed by the investigators to be of potential risk to the participant or validity of study results.","ALL","18 Years","80 Years",{"count":93,"type":94},120,"ESTIMATED","INTERVENTIONAL",[97],"NA","Background:\n\nAllergic and inflammatory conditions have been increasing over the years. Many factors may play a role in this. Every day, people are exposed to pollution and chemicals in our foods, clothing, and all of the cleaning, hygiene, and other products we use. Studies have suggested there may be links between these environmental exposures and allergic and inflammatory illnesses. Researchers want to know more about how these exposures affect our health.\n\nObjective:\n\nTo learn how everyday exposure to common substances affects people's health.\n\nEligibility:\n\nHealthy people aged 18 to 80 years.\n\nDesign:\n\nParticipants will have 2 stays in the hospital. Each stay will last 7 days, and the stays will be spaced 4 to 6 weeks apart. During both stays, participants will remain confined to their room. They will eat only food from the menu, and they will use only provided products for personal care. (They may bring their own electronic devices, such as their phone and computer.)\n\nOne stay will be in a pure room. Participants will breathe filtered air, eat unprocessed foods, and use personal care products with fewer chemicals.\n\nOne stay will be in a room that allows exposure to common environmental chemicals. Some participants will be limited to only 1 type of exposure: chemicals thought to affect only skin, gut, or respiratory health. Some participants will be exposed to all 3 types.\n\nParticipants will undergo testing. Blood, skin cell, urine, mouth swabs, and stool samples will be taken. They will have lung tests, smell tests, and tests that measure the health of their skin.\n\nThese tests will be repeated in outpatient visits 2 weeks after each hospital stay....",[100,101],"Allergic","Inflammatory",[38,103,104],"Skin barrier dysfunction","Skin impedance","2026-06-17",{"date":107,"type":108},"2026-06-18","ACTUAL",{"date":110,"type":108},"2026-04-15",{"date":112,"type":94},"2031-01-30",{"name":49,"class":6},1]