[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100627337":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":23,"centralContacts":31,"locations":39,"responsibleParty":55,"collaborators":10,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":10,"eligibilityCriteria":64,"healthyVolunteers":65,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":10,"studyType":72,"phases":10,"briefSummary":73,"conditions":74,"keywords":76,"overallStatus":41,"whyStopped":10,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Hacettepe University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"TMC OA Group (Eaton-Littler Stages I-IV)",null,"Individuals diagnosed with trapeziometacarpal (TMC) joint osteoarthritis. Disease stage will be determined on radiographs using the Eaton-Littler classification (Stages I-IV). Thumb proprioception will be quantified using joint position sense measurements at the TMC, MCP, and IP joints and a pinch aperture proprioception task (error measures). We will also examine potential determinants of thumb proprioceptive function, including demographic characteristics, motor function, sensory function, and emotional status. To evaluate intra-rater repeatability of the pinch aperture proprioception measure, the same assessor will repeat the test within one week in a subgroup of 30 participants.",[13],"Other: Thumb Proprioception Assessment",{"label":15,"type":10,"description":16,"interventionNames":17},"Healthy Control Group","Healthy individuals enrolled as a comparison group. Thumb proprioception will be assessed using joint position sense measurements at the TMC, MCP, and IP joints and a pinch aperture proprioception task (error measures), and results will be compared with those of the TMC osteoarthritis group.",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"Thumb Proprioception Assessment","This is an observational study. All participants undergo a standardized thumb proprioception assessment performed by the same assessor. Proprioception is evaluated using (1) joint position sense error at the thumb trapeziometacarpal, metacarpophalangeal, and interphalangeal joints, and (2) pinch aperture proprioception error. No therapeutic intervention is delivered; assessments are for measurement purposes only.",[15,9],[24,28],{"name":25,"affiliation":26,"role":27},"Çiğdem Ayhan Kuru, PT, PhD","Faculty of Physiotherapy and Rehabilitation, Department of Orthopedic Physiotherapy and Rehabilitation, Hacettepe University, Ankara, Turkey","PRINCIPAL_INVESTIGATOR",{"name":29,"affiliation":26,"role":30},"Merve Sümeyye Yılmaz, PT","STUDY_DIRECTOR",[32,36],{"name":29,"role":33,"phone":34,"phoneExt":10,"email":35},"CONTACT","+90 507 843 82 69","mervesumeyyeyilmaz@icloud.com",{"name":25,"role":33,"phone":37,"phoneExt":10,"email":38},"+90 542 316 02 42","cayhan@hacettepe.edu.tr",[40],{"facility":5,"status":41,"city":42,"state":42,"zip":43,"country":44,"countryCode":10,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"RECRUITING","Ankara","06100","Turkey (Türkiye)",{"type":46,"coordinates":47},"Point",[48,49],32.85427,39.91987,{"lat":49,"lon":48},[52,53],{"name":25,"role":27,"phone":10,"phoneExt":10,"email":10},{"name":29,"role":54,"phone":10,"phoneExt":10,"email":10},"SUB_INVESTIGATOR",{"type":27,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Cigdem Ayhan","Professor","100627337","thumb-proprioception-in-trapeziometacarpal-osteoarthritis-100627337",false,"NCT07447323","Thumb Proprioception in Trapeziometacarpal Osteoarthritis","Investigation of Thumb Proprioception in Trapeziometacarpal Joint Osteoarthritis","Inclusion Criteria (TMC OA group):\n\n* Voluntary participation\n* Radiographic Eaton-Littler stage I-IV confirmed by an orthopedic specialist\n* Symptom duration ≥6 months\n* Age 25-75 years\n* Pain intensity ≥4\u002F10 on the Visual Analog Scale (VAS) during daily activities at assessment\n* Ability to actively perform ≥40° palmar abduction\n* Adequate cognitive capacity to understand and perform study procedures (for participants aged ≥65 years: Montreal Cognitive Assessment \\[MoCA\\] score ≥21)\n\nInclusion Criteria (Control group):\n\n* Voluntary participation\n* No thumb pain\n* Age 25-75 years\n* No clinical signs of TMC OA\n* Negative provocation tests\n* Adequate cognitive capacity to understand and perform study procedures (for participants aged ≥65 years: MoCA score ≥21)\n\nExclusion Criteria (TMC OA group):\n\n* Inability to abduct the thumb beyond 40° due to severe pain\u002Fdeformity (especially advanced stage III-IV)\n* Acute trauma or prior surgery of the hand\u002Fwrist\n* Conservative treatment for hand\u002Fthumb pain in the same extremity within the previous 6 months\n* Current use of anti-inflammatory medication\n* Peripheral nerve disorders affecting proprioception (e.g., carpal tunnel syndrome, dorsal radial nerve irritation, cervical radiculopathy, double crush syndrome)\n* Concomitant upper-extremity musculoskeletal disorders (e.g., trigger finger, De Quervain's disease)\n* Generalized joint hypermobility (Beighton score ≥4)\n* Neuromuscular, systemic peripheral neuropathic, autoimmune, rheumatic, or infectious diseases\n* Active malignancy\n* Neurological conditions affecting pain perception\n* Visual impairment\n* Pregnancy\n\nExclusion Criteria (Control group):\n\n-Exclusion criteria identical to the TMC OA group",true,"ALL","25 Years","75 Years",{"count":70,"type":71},100,"ESTIMATED","OBSERVATIONAL","This study looks at people who have osteoarthritis at the base of the thumb. It examines how well the thumb can sense its position and movement.\n\nThe study has three goals:\n\n1. To compare these measurements between people with thumb base osteoarthritis and healthy people.\n2. To find out whether this ability changes from milder to more advanced levels of osteoarthritis.\n3. To explore whether this ability is related to factors such as basic personal characteristics, thumb\u002Fhand muscle strength and hand use, pain and touch sensation, and emotional factors like fear of movement, anxiety, and depression.\n\nThis is an observational study. No treatment is given. Participants complete thumb measurements and several tests\u002Fquestionnaires.",[75],"Trapeziometacarpal Osteoarthritis",[77,78,79,80,81,82,83,84,85,86,87],"Thumb proprioception","Joint position sense","Pinch aperture proprioception","Trapeziometacarpal joint","Pain","Proprioception","Carpometacarpal","Proprioception*","Thumb*","Carpometacarpal Joints*","Humans","2026-02-26",{"date":90,"type":91},"2026-03-03","ACTUAL",{"date":93,"type":91},"2025-10-23",{"date":95,"type":71},"2026-05",{"name":5,"class":6},1]