[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100483908":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":18,"centralContacts":23,"locations":27,"responsibleParty":44,"collaborators":10,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":49,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":10,"studyType":61,"phases":10,"briefSummary":62,"conditions":63,"keywords":67,"overallStatus":30,"whyStopped":10,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"University of Roma La Sapienza","OTHER",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Klinefelter syndrome",null,"Males affected by 47,XXY non-mosaic Klinefelter syndrome. Subgroups according to pubertal stage: pre-pubertal, pubertal and adults. Subgroups according to gonadal status: eugonadal, hypogonadal and receiving testosterone replacement therapy (TRT).",{"label":13,"type":10,"description":14,"interventionNames":10},"Healthy controls","Euthyroid, age- and pubertal stage-matched males Subgroups according to pubertal stage: pre-pubertal, pubertal and adults.",{"label":16,"type":10,"description":17,"interventionNames":10},"Chronic lymphocytic thyroiditis","Adult males affected by chronic lymphocytic thyroiditis",[19],{"name":20,"affiliation":21,"role":22},"Andrea M Isidori, MD, PhD","andrea.isidori@uniroma1.it","PRINCIPAL_INVESTIGATOR",[24],{"name":20,"role":25,"phone":26,"phoneExt":10,"email":21},"CONTACT","0039649970711",[28],{"facility":29,"status":30,"city":31,"state":10,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"'Sapienza' University of Rome","RECRUITING","Roma","00161","Italy","IT",{"type":36,"coordinates":37},"Point",[38,39],11.10642,44.99364,{"lat":39,"lon":38},[42],{"name":43,"role":25,"phone":10,"phoneExt":10,"email":21},"Andrea Isidori, MD, Ph.D.",{"type":22,"investigatorFullName":45,"investigatorTitle":46,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Andrea M. Isidori","Full professor","100483908","thyroid-function-and-structure-in-klinefelter-syndrome-100483908",false,"NCT05581147","Thyroid Function and Structure in Klinefelter Syndrome","Thyroid Function and Structure in Klinefelter Syndrome (THINKS)","THINKS","Inclusion Criteria:\n\n* Patients with a confirmed diagnosis of classic, non-mosaic 47,XXY Klinefelter syndrome based on a peripheral blood 97 karyotype analysis;\n* Availability of thyroid function test results (TSH, fT3, and fT4) and\u002For thyroid US imaging;\n* Availability of concurrent clinical data.\n\nExclusion Criteria:\n\n* Presence of other known genetic conditions or chromosomal abnormalities;\n* Use of levothyroxine or other drugs that are either active on the hypothalamic-pituitary-thyroid (HPT) axis or that may interfere with thyroid function tests;\n* History of previous surgery or radiotherapy on the thyroid or pituitary glands;\n* Current or previous T therapy (for the pre-pubertal and pubertal groups).","MALE","1 Year","80 Years",{"count":59,"type":60},600,"ESTIMATED","OBSERVATIONAL","This is a longitudinal retrospective study for the evaluation of thyroid function and structure in patients with Klinefelter syndrome compared to healthy controls and patients affected by chronic lymphocytic thyroiditis.",[64,65,66],"Klinefelter Syndrome","Thyroiditis, Autoimmune","Hypothyroidism",[9,66,68,69,70,71],"Thyroiditis","Puberty","Prepuberty","Testosterone","2025-03-25",{"date":74,"type":75},"2025-03-30","ACTUAL",{"date":77,"type":75},"2007-05-11",{"date":79,"type":60},"2026-12-01",{"name":5,"class":6},1]