[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626284":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":15,"centralContacts":19,"locations":28,"responsibleParty":61,"collaborators":7,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":7,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":7,"enrollmentInfo":72,"targetDuration":7,"studyType":75,"phases":7,"briefSummary":76,"conditions":77,"keywords":81,"overallStatus":31,"whyStopped":7,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Yale University","OTHER",null,[9],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":13},"PROCEDURE","Basivertebral nerve ablation","Participants underwent fluoroscopically guided intraosseous basivertebral nerve ablation (BVNA) using the Intracept® System (Boston Scientific, MA, USA) targeting MRI-confirmed Modic type 1 or 2 vertebral endplate changes. Procedures were performed under general anesthesia via a transpedicular or parapedicular approach with biplanar fluoroscopic confirmation of probe placement at the basivertebral foramen (30-50% vertebral body depth, midline AP position). Thermal radiofrequency ablation was delivered using either 75°C for 7 minutes (targeted lesion) or 85°C for 15 minutes (expanded lesion), selected based on intraoperative probe proximity to the intended target to optimize nerve capture. Only levels with imaging-confirmed Modic changes were treated. Weekly patient-reported outcomes were collected for 8, 12, 24 , 48 through 98 weeks.",[14],"Basivertebral Nerve Radiofrequency Ablation",[16],{"name":17,"affiliation":5,"role":18},"Charles A Odonkor, MD","PRINCIPAL_INVESTIGATOR",[20,24],{"name":17,"role":21,"phone":22,"phoneExt":7,"email":23},"CONTACT","203-767-1555","kcodonkor@aya.yale.edu",{"name":25,"role":21,"phone":26,"phoneExt":7,"email":27},"Muhammad U Siddique, MD","203-668-2772","muhammad.siddique@yale.edu",[29,43,52],{"facility":30,"status":31,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":7},"Yale Spine and Pain Center - Guilford","RECRUITING","Guilford","Connecticut","06437","United States","US",{"type":38,"coordinates":39},"Point",[40,41],-72.68176,41.28899,{"lat":41,"lon":40},{"facility":44,"status":31,"city":45,"state":33,"zip":46,"country":35,"countryCode":36,"cosmosGeoPoint":47,"geoPoint":51,"contacts":7},"Yale Pain Management Center - New Haven","New Haven","06519",{"type":38,"coordinates":48},[49,50],-72.92816,41.30815,{"lat":50,"lon":49},{"facility":53,"status":31,"city":54,"state":33,"zip":55,"country":35,"countryCode":36,"cosmosGeoPoint":56,"geoPoint":60,"contacts":7},"Yale Interventional Spine and Musculoskeletal Medicine - Old Saybrook","Old Saybrook","06475",{"type":38,"coordinates":57},[58,59],-72.3762,41.29177,{"lat":59,"lon":58},{"type":62,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100626284","time-to-bbvna-relief-100626284",false,"NCT07433634","Time to BBVNA Relief","Temporal Trends and Predictors of Clinical Response Following Basivertebral Nerve (BVN) Ablation: A Prospective Observational Cohort Study","Inclusion Criteria:\n\n* Diagnosis of chronic axial low back pain with vertebrogenic features\n* Scheduled for BVN ablation\n* Able to provide informed consent\n* Capable of participating in weekly virtual\u002Ftelephone follow-up for 8 weeks and in- person or remote follow-up at 3 and 6 months through 2 years\n\nExclusion Criteria:\n\n* Prior spinal neuromodulation therapy (e.g., spinal cord stimulation or intrathecal pump) within the past 6 months\n* Active substance use disorder or uncontrolled psychiatric illness that may interfere with participation\n* Cognitive impairment limiting ability to complete surveys or provide informed consent\n* Pregnancy\n* Incarceration or current status as a prisoner","ALL","18 Years",{"count":73,"type":74},200,"ESTIMATED","OBSERVATIONAL","Basivertebral nerve ablation (BVNA) is a minimally invasive procedure approved for vertebrogenic low back pain. While early studies support its efficacy, real-world evidence is still evolving, particularly regarding the trajectory of pain relief and functional improvement over time, and predictors of clinical response. This study aims to evaluate clinical outcomes longitudinally following BVNA and identify baseline predictors of response.",[78,79,80],"Low Back Pain","Vertebrogenic Pain Syndrome","Basivertebral Nerve Ablation",[82,11,83,84,85,86],"Pain relief trajectory","Vertebrogenic low back pain,","Responder phenotypes","Clinical Outcomes","Radiofrequency Ablation","2026-02-27",{"date":89,"type":90},"2026-03-03","ACTUAL",{"date":92,"type":90},"2024-04-19",{"date":94,"type":74},"2026-10",{"name":5,"class":6},3]