[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100593109":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":41,"responsibleParty":184,"collaborators":26,"id":187,"slug":188,"hasResults":189,"nctId":190,"briefTitle":191,"officialTitle":192,"acronym":193,"eligibilityCriteria":194,"healthyVolunteers":189,"sex":195,"minAge":196,"maxAge":26,"enrollmentInfo":197,"targetDuration":26,"studyType":200,"phases":201,"briefSummary":203,"conditions":204,"keywords":207,"overallStatus":44,"whyStopped":26,"lastUpdateSubmitDate":212,"lastUpdatePostDateStruct":213,"startDateStruct":216,"completionDateStruct":218,"leadSponsor":220,"locationsCount":221},{"fullName":5,"class":6},"Chonnam National University Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Immediate coronary angiography within 2 hours after diagnosis of non-ST-segment elevation myocardial","EXPERIMENTAL","Coronary angiography will be performed within 2 hours after diagnosis of non-ST-segment elevation myocardial infarction.",[13],"Procedure: Immediate coronary angiography",{"label":15,"type":16,"description":17,"interventionNames":18},"Delayed coronary angiography after stabilization of acute decompensated heart failure","ACTIVE_COMPARATOR","Coronary angiography will be performed after disappearance of symptoms and signs of acute decompensated heart failure.",[19],"Procedure: Delayed coronary angiography",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Immediate coronary angiography","Immediate coronary angiography ≤2 hours after randomization",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Delayed coronary angiography","Delayed coronary angiography after stabilization",[15],[32,37],{"name":33,"role":34,"phone":35,"phoneExt":35,"email":36},"Youngkeun Ahn, Professor","CONTACT","82-62-220-4764","cecilyk@hanmail.net",{"name":38,"role":34,"phone":39,"phoneExt":39,"email":40},"Min Chul Kim, Professor","82-62-220-6578","kmc3242@hanmail.net",[42,53,61,67,72,80,92,97,102,110,118,126,134,142,148,153,158,163,168,176],{"facility":43,"status":44,"city":45,"state":26,"zip":26,"country":46,"countryCode":26,"cosmosGeoPoint":47,"geoPoint":52,"contacts":26},"Gyeongsang National University Changwon Hospital","RECRUITING","Changwon","South Korea",{"type":48,"coordinates":49},"Point",[50,51],128.68111,35.22806,{"lat":51,"lon":50},{"facility":54,"status":44,"city":55,"state":26,"zip":26,"country":46,"countryCode":26,"cosmosGeoPoint":56,"geoPoint":60,"contacts":26},"Keimyung University Dongsan Hospital","Daegu",{"type":48,"coordinates":57},[58,59],128.59111,35.87028,{"lat":59,"lon":58},{"facility":62,"status":63,"city":55,"state":26,"zip":26,"country":46,"countryCode":26,"cosmosGeoPoint":64,"geoPoint":66,"contacts":26},"Kyungpook National University Hospital","NOT_YET_RECRUITING",{"type":48,"coordinates":65},[58,59],{"lat":59,"lon":58},{"facility":68,"status":44,"city":55,"state":26,"zip":26,"country":46,"countryCode":26,"cosmosGeoPoint":69,"geoPoint":71,"contacts":26},"Yeongnam University Medical Center",{"type":48,"coordinates":70},[58,59],{"lat":59,"lon":58},{"facility":73,"status":44,"city":74,"state":26,"zip":26,"country":46,"countryCode":26,"cosmosGeoPoint":75,"geoPoint":79,"contacts":26},"Chungnam National University Hospital","Daejeon",{"type":48,"coordinates":76},[77,78],127.38493,36.34913,{"lat":78,"lon":77},{"facility":5,"status":44,"city":81,"state":26,"zip":26,"country":46,"countryCode":26,"cosmosGeoPoint":82,"geoPoint":86,"contacts":87},"Gwangju",{"type":48,"coordinates":83},[84,85],126.91556,35.15472,{"lat":85,"lon":84},[88,90],{"name":33,"role":89,"phone":26,"phoneExt":26,"email":26},"PRINCIPAL_INVESTIGATOR",{"name":38,"role":91,"phone":26,"phoneExt":26,"email":26},"SUB_INVESTIGATOR",{"facility":93,"status":44,"city":81,"state":26,"zip":26,"country":46,"countryCode":26,"cosmosGeoPoint":94,"geoPoint":96,"contacts":26},"Gwangju Veterans Hospital",{"type":48,"coordinates":95},[84,85],{"lat":85,"lon":84},{"facility":98,"status":63,"city":81,"state":26,"zip":26,"country":46,"countryCode":26,"cosmosGeoPoint":99,"geoPoint":101,"contacts":26},"Kwangju Christian Hospital",{"type":48,"coordinates":100},[84,85],{"lat":85,"lon":84},{"facility":103,"status":44,"city":104,"state":26,"zip":26,"country":46,"countryCode":26,"cosmosGeoPoint":105,"geoPoint":109,"contacts":26},"Jeonbuk National University Hospital","Jeonju",{"type":48,"coordinates":106},[107,108],127.14889,35.82194,{"lat":108,"lon":107},{"facility":111,"status":44,"city":112,"state":26,"zip":26,"country":46,"countryCode":26,"cosmosGeoPoint":113,"geoPoint":117,"contacts":26},"Gyeongsang National University Hospital","Jinju",{"type":48,"coordinates":114},[115,116],128.08472,35.19278,{"lat":116,"lon":115},{"facility":119,"status":63,"city":120,"state":26,"zip":26,"country":46,"countryCode":26,"cosmosGeoPoint":121,"geoPoint":125,"contacts":26},"Dong-A University Hospital","Pusan",{"type":48,"coordinates":122},[123,124],128.02524,35.70128,{"lat":124,"lon":123},{"facility":127,"status":63,"city":128,"state":26,"zip":26,"country":46,"countryCode":26,"cosmosGeoPoint":129,"geoPoint":133,"contacts":26},"Seoul National University Bundang Hospital","Seongnam",{"type":48,"coordinates":130},[131,132],127.7548,36.4052,{"lat":132,"lon":131},{"facility":135,"status":44,"city":136,"state":26,"zip":26,"country":46,"countryCode":26,"cosmosGeoPoint":137,"geoPoint":141,"contacts":26},"Asan Medical Center","Seoul",{"type":48,"coordinates":138},[139,140],126.9784,37.566,{"lat":140,"lon":139},{"facility":143,"status":144,"city":136,"state":26,"zip":26,"country":46,"countryCode":26,"cosmosGeoPoint":145,"geoPoint":147,"contacts":26},"Kangbuk Samsung Medical Center","WITHDRAWN",{"type":48,"coordinates":146},[139,140],{"lat":140,"lon":139},{"facility":149,"status":63,"city":136,"state":26,"zip":26,"country":46,"countryCode":26,"cosmosGeoPoint":150,"geoPoint":152,"contacts":26},"Koera University Guro Hospital",{"type":48,"coordinates":151},[139,140],{"lat":140,"lon":139},{"facility":154,"status":44,"city":136,"state":26,"zip":26,"country":46,"countryCode":26,"cosmosGeoPoint":155,"geoPoint":157,"contacts":26},"Korea University Anam Hospital",{"type":48,"coordinates":156},[139,140],{"lat":140,"lon":139},{"facility":159,"status":44,"city":136,"state":26,"zip":26,"country":46,"countryCode":26,"cosmosGeoPoint":160,"geoPoint":162,"contacts":26},"Samsung Medical Center",{"type":48,"coordinates":161},[139,140],{"lat":140,"lon":139},{"facility":164,"status":63,"city":136,"state":26,"zip":26,"country":46,"countryCode":26,"cosmosGeoPoint":165,"geoPoint":167,"contacts":26},"Seoul National University Hospital",{"type":48,"coordinates":166},[139,140],{"lat":140,"lon":139},{"facility":169,"status":44,"city":170,"state":26,"zip":26,"country":46,"countryCode":26,"cosmosGeoPoint":171,"geoPoint":175,"contacts":26},"St. Carollo General Hospital","Suncheon",{"type":48,"coordinates":172},[173,174],127.48784,34.9505,{"lat":174,"lon":173},{"facility":177,"status":44,"city":178,"state":26,"zip":26,"country":46,"countryCode":26,"cosmosGeoPoint":179,"geoPoint":183,"contacts":26},"Yonsei University, Wonju Severance Christian Hospital","Wŏnju",{"type":48,"coordinates":180},[181,182],127.94528,37.35139,{"lat":182,"lon":181},{"type":89,"investigatorFullName":185,"investigatorTitle":186,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Min Chul Kim","Professor","100593109","timing-of-coronary-angiography-in-nstemi-complicated-by-acute-hf-100593109",false,"NCT07002164","Timing of Coronary Angiography in NSTEMI Complicated by Acute HF","Trial of IMmediate Invasive Versus Delayed Coronary ANGiography in Non-ST-Segment Elevation Myocardial Infarction Complicated by Acute Decompensated Heart Failure: The TIMING-AHF Trial","TIMING-AHF","Inclusion Criteria:\n\n* Age ≥19 years\n* Non-ST-segment elevation myocardial infarction\n* New-onset or worsening of dyspnea (New York Heart Association class ≥2)\n* Pulmonary congestion\n* Patient's or guardian's consent after understanding the study\n\nExclusion Criteria:\n\n* Cardiogenic shock at initial presentation\n* ST-segment elevation myocardial infarction\n\n  * ST-segment elevation ≥0.1 mV in at least 2 contiguous leads, or\n  * New onset left bundle branch block\n  * Posterior wall myocardial infarction\n* Refractory angina\n* Life threatening ventricular arrhythmias\n* Life expectancy \\\u003C1 year\n* Apparently non-ischemic cause of HF\n* Pregnancy and lactation\n* History of coronary artery bypass grafting (CABG), or planned CABG\n* Patient's refusal to participate in study","ALL","19 Years",{"count":198,"type":199},780,"ESTIMATED","INTERVENTIONAL",[202],"NA","Study objectives:\n\nTo determine the optimal timing of coronary angiography (CAG) in patients with non-ST-segment elevation myocardial infarction (NSTEMI) complicated by acute decompensated heart failure (AHF). The primary objective of this trial is to test the hypothesis that immediate CAG ≤2 hours after establishment of NSTEMI diagnosis would result in a significant reduction in primary composite outcome of death from any cause, non-fatal myocardial infarction (MI), or hospitalization for heart failure (HF) at 12 months after randomization as compared with delayed CAG after stabilization.\n\nStudy hypothesis:\n\nImmediate CAG ≤2 hours after establishment of NSTEMI diagnosis would result in a significant reduction in primary composite outcome of death from any cause, non-fatal myocardial infarction (MI), or hospitalization for heart failure (HF) at 12 months after randomization as compared with delayed CAG after stabilization.\n\nBackground:\n\nAlthough current guidelines recommend early CAG within 2 hours for patients with NSTEMI complicated by AHF, many patients with NSTEMI complicated by AHF did not receive early CAG. However, no randomized clinical trials have evaluated the optimal timing of CAG in patients with NSTEMI complicated by AHF. Therefore, the investigators aimed to perform a prospective, investigator-initiated, open-label, muilticenter trial to compare the efficacy and safety between immediate CAG (CAG \\\u003C2 hours after establishment of NSTEMI diagnosis) and delayed CAG after stabilization (i.e. improved dyspnea and disappearance of pulmonary congestion) in participants with NSTEMI complicated by AHF.\n\nStudy procedure:\n\nFollowing the establishment of NSTEMI diagnosis, participants fulfilling the eligibility criteria will be randomized at a ratio of 1:1 to immediate CAG ≤2 hours after randomization or delayed CAG after stabilization on another day during hospitalization.",[205,206],"Myocardial Infarction (MI)","Heart Failure",[208,209,210,211],"Non-ST-segment elevation myocardial infarction","Acute decompensated heart failure","Coronary angiography","Timing","2026-03-17",{"date":214,"type":215},"2026-03-19","ACTUAL",{"date":217,"type":215},"2025-07-15",{"date":219,"type":199},"2032-04-30",{"name":5,"class":6},20]