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Pascale","Naples",{"type":44,"coordinates":195},[196,197],14.26811,40.85216,{"lat":197,"lon":196},[200,202,203],{"name":201,"role":31,"phone":24,"phoneExt":24,"email":24},"Paolo Delrio, Prof",{"name":201,"role":54,"phone":24,"phoneExt":24,"email":24},{"name":204,"role":57,"phone":24,"phoneExt":24,"email":24},"Daniela Rega, MD",{"facility":206,"status":207,"city":208,"state":24,"zip":24,"country":41,"countryCode":42,"cosmosGeoPoint":209,"geoPoint":213,"contacts":24},"Ospedale San Francesco","TERMINATED","Nuoro",{"type":44,"coordinates":210},[211,212],9.32568,40.31991,{"lat":212,"lon":211},{"facility":215,"status":105,"city":216,"state":24,"zip":24,"country":41,"countryCode":42,"cosmosGeoPoint":217,"geoPoint":221,"contacts":24},"Azienda Ospedaliera San Giovanni - Addolorata","Roma",{"type":44,"coordinates":218},[219,220],11.10642,44.99364,{"lat":220,"lon":219},{"type":54,"investigatorFullName":223,"investigatorTitle":224,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Igor Monsellato","Principal Investigator","100321524","timing-to-minimally-invasive-surgery-after-neoadjuvant-chemoradiotherapy-for-rectal-cancer-100321524",false,"NCT03465982","Timing to Minimally Invasive Surgery After Neoadjuvant Chemoradiotherapy for Rectal Cancer","Timing to Minimally Invasive Surgery After Neoadjuvant Chemoradiotherapy for Rectal Cancer: a Multicenter Randomised Controlled Trial","TiMiSNAR","Inclusion Criteria:\n\n* Age \\>18 years\n* cT3\u002F4N0\u002F+M0 confirmed on CT-scan, MRI (stratification for T3a-b-c-d) 3\n* Tumor starting from the distal or medium rectum (even those crossing the peritoneal reflection at distal margin, within 15 cm from the anal margin)\n* Histologically-proven adenocarcinoma of the rectum\n* Eligible for a resective surgery with TME (low anterior resection, intersphincteric resection, abdominoperineal resection)\n* Eligible for resection by minimally-invasive surgery (standard or robotic-assisted laparoscopic procedure, all robotic systems will be accepted)\n* Eligible for chemoradiation treatment\n* Able to give written informed consent\n* Capable of completing required questionnaires at time of consent (provided questionnaires are available in a language spoke fluently by the participant)\n\nExclusion Criteria:\n\n* Metastatic disease\n* Squamous carcinoma of the anal canal\n* Synchronous colorectal tumors requiring multi-segment surgical resection (n.b. a benign lesion within the resection field in addition to the main cancer would not exclude a patient)\n* History of psychiatric or addictive disorder or other medical condition that, in the opinion of the investigator, would preclude the patient from meeting the trial requirements\n* Pregnancy\n* Unable to complete neoadjuvant treatment\n* Unable to give free informed consent\n* Previous radiation treatment on the pelvis\n* Inflammatory bowel disease\n* Hereditary colorectal disease\n* Previous tumors other than non-melanoma skin cancer, papillary or follicular thyroid cancer\n* Participation in another rectal cancer clinical trial relating to the topic of this trial","ALL","18 Years",{"count":236,"type":237},340,"ESTIMATED","INTERVENTIONAL",[240],"NA","The trial is a multicenter, prospective, randomized controlled, unblinded, parallel-group trial comparing standard and delayed surgery after neoadjuvant chemoradiotherapy for the curative treatment of rectal cancer. 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