[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100632159":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":22,"centralContacts":30,"locations":41,"responsibleParty":82,"collaborators":85,"id":90,"slug":91,"hasResults":92,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":96,"eligibilityCriteria":97,"healthyVolunteers":98,"sex":99,"minAge":100,"maxAge":101,"enrollmentInfo":102,"targetDuration":46,"studyType":105,"phases":106,"briefSummary":108,"conditions":109,"keywords":116,"overallStatus":44,"whyStopped":46,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":139},{"fullName":5,"class":6},"University of Thessaly","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Standardized Heat and UV Exposure Protocol","EXPERIMENTAL","Participants undergo a standardized 4-hour laboratory protocol to assess physiological and psychological responses to controlled heat and ultraviolet radiation exposure. The protocol includes passive heat exposure (40°C, 30% relative humidity), simulated solar UV radiation (up to 3 Standard Erythema Doses), light exercise-induced heat stress, and recovery. Core and skin temperature, cardiovascular and thermoregulatory responses, orthostatic tolerance, echocardiography, blood and urine biomarkers, skin biopsies, motor-cognitive performance, and psychological measures are assessed repeatedly. Subgroup analyses compare participants by geographic location (Denmark vs Greece) and pre-defined heat tolerance status (low vs high).",[13],"Other: Controlled Heat and Ultraviolet Radiation Exposure Protocol",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"Controlled Heat and Ultraviolet Radiation Exposure Protocol","Participants undergo a standardized 4-hour laboratory-based environmental exposure protocol consisting of passive heat exposure (40°C, 30% relative humidity), simulated solar ultraviolet radiation (up to 3 Standard Erythema Doses), light exercise-induced heat stress using a cycle ergometer, and recovery. Physiological, cardiovascular, thermoregulatory, biochemical, and psychological responses are assessed repeatedly throughout the protocol. The intervention is designed to quantify individual heat tolerance and combined heat-UV physiological strain under controlled conditions.",[9],[20,21],"Standardized Heat Stress Protocol","Simulated Solar Radiation Exposure",[23,27],{"name":24,"affiliation":25,"role":26},"Andreas D Flouris, PhD","1FAME Laboratory, Department of Exercise Science, University of Thessaly, Trikala, Greece","PRINCIPAL_INVESTIGATOR",{"name":28,"affiliation":29,"role":26},"Lars Nybo, PhD","Department of Nutrition, Exercise and Sports, August Krogh Building, University of Copenhagen, Copenhagen, Denmark.",[31,37],{"name":32,"role":33,"phone":34,"phoneExt":35,"email":36},"Maria Vliora, PhD","CONTACT","6979642540","+30","mvliora@gmail.com",{"name":38,"role":33,"phone":39,"phoneExt":35,"email":40},"Konstantinos Mantzios, PhD","6948626874","konstantinosmantzios@gmail.com",[42,65],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Københavns Universitet","RECRUITING","Copenhagen",null,"2100","Denmark","DK",{"type":51,"coordinates":52},"Point",[53,54],12.56553,55.67594,{"lat":54,"lon":53},[57,62],{"name":58,"role":33,"phone":59,"phoneExt":60,"email":61},"Mathilde Lund, PhD","60701892","+45","mathilde.lund@nexs.ku.dk",{"name":63,"role":64,"phone":46,"phoneExt":46,"email":46},"Mathilde Lund, MSc","SUB_INVESTIGATOR",{"facility":66,"status":44,"city":67,"state":68,"zip":69,"country":70,"countryCode":71,"cosmosGeoPoint":72,"geoPoint":76,"contacts":77},"Department of Physical Education and Sport Science","Trikala","Thessaly","42100","Greece","GR",{"type":51,"coordinates":73},[74,75],21.76837,39.55493,{"lat":75,"lon":74},[78,79,80],{"name":32,"role":33,"phone":34,"phoneExt":35,"email":36},{"name":38,"role":33,"phone":39,"phoneExt":35,"email":40},{"name":81,"role":64,"phone":46,"phoneExt":46,"email":46},"Giorgos Gkikas, MSc",{"type":26,"investigatorFullName":83,"investigatorTitle":84,"investigatorAffiliation":5,"oldNameTitle":46,"oldOrganization":46},"Georgia Ntina","Head of Finance & Administration at FAME lab, DPESS, UTH",[86,88],{"name":87,"class":6},"University of Copenhagen",{"name":89,"class":6},"Bispebjerg Hospital","100632159","title-icarus---psycho-physiological-profiling-of-low-and-high-heat-resilient-individuals-100632159",false,"NCT07510061","Title: ICARUS - Psycho-physiological Profiling of Low and High Heat-resilient Individuals","Physiological Phenotyping","ICARUS","Study Population\n\nHealthy adult volunteers residing in Denmark (Northern Europe) or Greece (Southern Europe).\n\nInclusion Criteria\n\n* Age 18-65 years (or your protocol-specific age range)\n* Healthy as determined by medical history screening questionnaire\n* Able to provide written informed consent\n* Able to complete heat exposure and light exercise protocol\n* No heat acclimatization or extensive sun exposure in the previous 4 weeks\n* Fitzpatrick skin type I-IV (if applicable for UV testing)\n* Willing to undergo blood sampling, urine collection, and skin biopsy\n\nExclusion Criteria\n\n* History of cardiovascular, metabolic, neurological, or dermatological disease\n* History of heat-related illness (e.g., heat stroke)\n* Use of medications affecting thermoregulation or cardiovascular function\n* Smoking or substance abuse\n* Pregnancy or breastfeeding\n* Abnormal ECG or uncontrolled hypertension\n* Recent severe sunburn or UV treatment\n* Contraindications to skin biopsy\n* Inability to tolerate heat exposure during screening",true,"ALL","18 Years","65 Years",{"count":103,"type":104},80,"ESTIMATED","INTERVENTIONAL",[107],"NA","The escalating environmental heat-stress associated with global warming is a societal challenge with large and potential harmful consequences for humans. Excess morbidity and mortality during heat waves provides strong evidence for fatal outcomes. However, it is unclear why some people are particularly vulnerable and get sick from hyperthermia, while others adapt and tolerate exposure.\n\nThe Icarus project aims to provide a psycho-physiological framework for improved mitigation of the health threats associated with global warming. Combining expertise in integrative thermal physiology, pharmacology, photobiology, psychology and machine learning, we will collaborate on comprehensive cross-scientific studies using controlled lab-exposure combined with investigations in ecological settings including vulnerable and highly tolerant people across populations from northern to southern Europe.\n\nAdvanced algorithms will be developed to generate personalized alerts and advising based on behavioral patterns, psychological profiling, predicted vulnerability and willingness to adopt resilience-building strategies.\n\nGlobal warming is projected to continue towards the end of the 21st century and constitutes an increasing threat to human health unless we as individuals and collectively become better in preventing acute effects, as well as devise sustainable strategies to limit further anthropogenic warming of the climate system. Acutely, improved guidance is important for both individual and public health, where Icarus aims at providing a highly improved basis for preventing heat-related disease, advising or nudging people towards pro-health behavior, including smarter use of technologies to mitigate heat stress, or adjusting medication to reduce adverse effects during heat events. In support of the sustainability agenda, our framework also forms a novel basis for developing advising algorithms relevant for optimization of climate change mitigation policy-making.",[110,111,112,113,114,115],"Skin Cancer","Heat Tolerance","Heat-related Illness","Hyperthermia","Heat Stress","Ultraviolet Radiation-Related Skin Damage",[114,117,118,119,113,120,121,122,123,124,125,126,127,128,129],"Heat-Related Illness","Heat Vulnerability","Heat Intolerance","Environmental Heat Exposure","Thermal Stress","Ultraviolet Radiation Exposure","Skin DNA Damage","Cardiovascular Strain (Heat-Induced)","Cognitive Impairment (Heat-Induced)","Occupational Heat Stress","Climate Change and Health","Heat Resilience","Heat Acclimatization","2026-03-27",{"date":132,"type":133},"2026-04-03","ACTUAL",{"date":135,"type":133},"2025-11-01",{"date":137,"type":104},"2027-04-30",{"name":5,"class":6},2]