[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100549953":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":29,"locations":35,"responsibleParty":56,"collaborators":25,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":25,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":67,"maxAge":25,"enrollmentInfo":68,"targetDuration":25,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":25,"overallStatus":38,"whyStopped":25,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Universiti Sains Malaysia","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"oXiris filter","EXPERIMENTAL","Continuous Renal Replacement Therapy with the adsorption membrane filter Oxiris.\n\nThe specific septic biomarkers such as interleukin 6(IL-6), procalcitonin (PCT), C-reactive protein (CRP) along with other routine blood investigation results taken at the beginning of therapy and 24 hours after the treatment will be compared.\n\nThe 28-day mortality will be recorded following treatment.",[13],"Device: oXiris filter",{"label":15,"type":16,"description":17,"interventionNames":18},"M100 filter","ACTIVE_COMPARATOR","Continuous Renal Replacement Therapy with the adsorption membrane filter M100. The specific septic biomarkers such as interleukin 6(IL-6), procalcitonin (PCT), C-reactive protein (CRP) along with other routine blood investigation results taken at the beginning of therapy and 24 hours after the treatment will be compared.\n\nThe 28-day mortality will be recorded following treatment.",[19],"Device: M100 filter",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Continuous Renal Replacement Therapy with the adsorption membrane filter Oxiris.\n\nThe specific septic biomarkers such as interleukin 6(IL-6), procalcitonin (PCT), C-reactive protein (CRP) along with other routine blood investigation results taken at the beginning of therapy and 24 hours after the treatment will be compared.",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"Continuous Renal Replacement Therapy with the adsorption membrane filter M100. The specific septic biomarkers such as interleukin 6(IL-6), procalcitonin (PCT), C-reactive protein (CRP) along with other routine blood investigation results taken at the beginning of therapy and 24 hours after the treatment will be compared.",[15],[30],{"name":31,"role":32,"phone":33,"phoneExt":25,"email":34},"Marina Azidah Mat Zaid, MBBS","CONTACT","0199870715","marinazaid@yahoo.com",[36],{"facility":37,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Hospital Universiti Sains Malaysia (HUSM)","RECRUITING","Kubang Kerian","Kelantan","16150","Malaysia","MY",{"type":45,"coordinates":46},"Point",[47,48],102.27938,6.09123,{"lat":48,"lon":47},[51],{"name":52,"role":32,"phone":53,"phoneExt":54,"email":55},"Mohd Zulfakar Mazlan, MBBS","+6097673000","6104","zulfakar@usm.my",{"type":57,"investigatorFullName":52,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"SPONSOR_INVESTIGATOR","Associate Professor","100549953","to-compare-the-efficacy-and-safety-of-using-oxiris-and-m100-during-crrt-100549953",false,"NCT06440759","To Compare the Efficacy and Safety of Using oXiris and M100 During CRRT","Evaluation of Efficacy and Safety Using oXiris Versus M100 Filter in Pneumonia-induced Acute Kidney Injury (AKI) Patients Requiring Continuous Renal Replacement Therapy (CRRT)","Inclusion Criteria:\n\n* All adult patients aged\\>18 years old\n* Diagnosis of septic shock\n* Diagnosis of KDIGO stage 3 acute renal failure\n\nExclusion Criteria:\n\n* Moribund patient or patient that is expected to die within 72 hours\n* Pregnancy\n* patient with a bleeding tendency or known allergy to heparin","ALL","18 Years",{"count":69,"type":70},60,"ESTIMATED","INTERVENTIONAL",[73],"NA","The purpose of this study aimed to compare the efficacy of Oxiris (Baxter) and M100 filters on IL-6 as primary outcomes and other blood cell counts, blood biochemistry (serum urea, creatinine, potassium, sodium), inflammation indicators (CRP, PCT), as secondary outcomes and safety (28 days mortality as a primary outcome and coagulopathy, lifespan of filter, usage of vasopressor, clinical conditions (ventilator-free days, ICU and hospital- length of stay) as a secondary outcome), clinical conditions (ventilator-free days, ICU and hospital- length of stay), and mortality of patients with pneumonia-related AKI.",[76,77],"AKI - Acute Kidney Injury","Pneumonia","2025-09-30",{"date":80,"type":81},"2025-10-02","ACTUAL",{"date":83,"type":81},"2024-05-30",{"date":85,"type":70},"2026-05-01",{"name":52,"class":6},1]