[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100590260":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":26,"centralContacts":30,"locations":39,"responsibleParty":75,"collaborators":25,"id":77,"slug":78,"hasResults":79,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":79,"sex":85,"minAge":86,"maxAge":25,"enrollmentInfo":87,"targetDuration":25,"studyType":90,"phases":91,"briefSummary":93,"conditions":94,"keywords":96,"overallStatus":41,"whyStopped":25,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":112},{"fullName":5,"class":6},"The Christie NHS Foundation Trust","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"MRL","ACTIVE_COMPARATOR","Using the MR Linac to deliver Radiotherapy in a single treatment without the need for a prior planning CT scan.",[13],"Radiation: Radiotherapy to the spine in a single appointment",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard of Care","PLACEBO_COMPARATOR","Using a conventional linear accelerator to deliver Radiotherapy in a single treatment, participants will require a prior planning CT appointment before Radiotherapy can be delivered.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"RADIATION","Radiotherapy to the spine in a single appointment","8Gy\u002F 1# to be delivered to all participants using a single posterior direct field.",[9,15],null,[27],{"name":28,"affiliation":5,"role":29},"Cynthia L Eccles","PRINCIPAL_INVESTIGATOR",[31,36],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Clinical Trial Radiographer","CONTACT","+441614468386","the-christie.radiotherapyclinicaltrials@nhs.net",{"name":37,"role":33,"phone":34,"phoneExt":25,"email":38},"Alice Greenwood-Wilson","alice.greenwoodwilson@nhs.net",[40],{"facility":5,"status":41,"city":42,"state":25,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"RECRUITING","Manchester","M20 4BX","United Kingdom","UK",{"type":47,"coordinates":48},"Point",[49,50],-2.23743,53.48095,{"lat":50,"lon":49},[53,56,58,60,63,65,67,69,71,73],{"name":28,"role":33,"phone":54,"phoneExt":25,"email":55},"+447590992488","cynthia.eccles1@nhs.net",{"name":57,"role":33,"phone":25,"phoneExt":34,"email":35},"Research Radiographer",{"name":59,"role":29,"phone":25,"phoneExt":25,"email":25},"Cynthia L Eccles, MPhil",{"name":61,"role":62,"phone":25,"phoneExt":25,"email":25},"Peter Hoskin, FACR (Hon), FFR RCSI (Hon), MD","SUB_INVESTIGATOR",{"name":64,"role":62,"phone":25,"phoneExt":25,"email":25},"Ananya Choudhury, MA, PhD, MRCP, FRCR",{"name":66,"role":62,"phone":25,"phoneExt":25,"email":25},"Alice Greenwood-Wilson, BSc",{"name":68,"role":62,"phone":25,"phoneExt":25,"email":25},"Frank Brewster, MSc",{"name":70,"role":62,"phone":25,"phoneExt":25,"email":25},"Robert Chuter, PhD",{"name":72,"role":62,"phone":25,"phoneExt":25,"email":25},"Claire Shanahan, BSc",{"name":74,"role":62,"phone":25,"phoneExt":25,"email":25},"Vodathi Bamunarachchi, MD",{"type":76,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100590260","to-determine-whether-it-is-feasible-to-treat-patients-requiring-urgent-radiotherapy-diagnosed-with-metastatic-cord-compression-mscc-on-the-magnetic-resonance-linear-accelerator-mrl-in-a-single-appointment-and-compare-it-to-the-standard-of-care-radiotherapy-pathway-100590260",false,"NCT06965101","To Determine Whether it is Feasible to Treat Patients Requiring Urgent Radiotherapy Diagnosed With Metastatic Cord Compression (MSCC) on the Magnetic Resonance Linear Accelerator (MRL) in a Single Appointment and Compare it to the Standard of Care Radiotherapy Pathway","Rapid Response MRI-Guided Palliative Radiotherapy","RESONATE","Inclusion Criteria:\n\n* Confirmed Diagnosis of MSCC\n* Referred for an 8Gy, Single Fraction of Radiotherapy\n* 18 years or older.\n* Able to give informed consent in writing or verbally.\n* Willing to complete patient experience questionnaire\n* Willing to have the research team review their case notes for up to 1 year following\n\nExclusion Criteria:\n\n* Participant does not have capacity and cannot give informed consent.\n* Any evidence of significant clinical disorder or laboratory finding which, in the opinion of the investigator, make it undesirable for the patient to participate in the study.\n* Participant is unwilling to allow researchers to access their clinical notes and diagnostic scans.\n* Participant is unwilling to complete an experience questionnaire\n* The participant cannot speak or understand English.\n\nExclusion Criteria MRL arm:\n\n* Any contraindications to MRI identified after MRI safety screening\n* Unable to tolerate MRI scanning\n* Uncontrolled pain\u002F poor pain control.\n* MSCC in the cervical spine.\n* More than one vertebral level of compression","ALL","18 Years",{"count":88,"type":89},72,"ESTIMATED","INTERVENTIONAL",[92],"NA","The goal of this clinical trial is to understand whether the Magnetic Resonance Linear Accelerator (MRL) could expedite Radiotherapy treatment for Metastatic Cord Compression (MSCC) by removing the need for a planning CT (pCT) scan prior to treatment. Radiotherapy will be delivered in one appointment on the MRL and compared to the standard of care of two appointments: a CT scan and a Radiotherapy appointment.\n\nThe main questions it aims to answer are:\n\n* Can the MRL deliver successful treatment of MSCC in a single 1-hour appointment?\n* Can the MRL treat participants within 24 hours from the doctor's decision to treat?\n* Did it take less time from consent to completion of treatment when patients were treated on the MRL?\n* Do the questionnaire scores reflect satisfaction with treatment on the MRL? Researchers will compare treatment on the MRL in one appointment to a group receiving standard of care radiotherapy in two appointments.\n\nParticipants in both groups will receive the same prescription of 8Gray (Gy) in one treatment (fraction) delivered with one posterior-anterior beam as per our department policies and national standards.\n\nParticipants will be asked to complete an optional questionnaire prior to treatment to monitor the diversity of the study population. This questionnaire is anonymised, no personal data that could identify a participant is collected on this questionnaire.\n\nAfter treatment participants will be asked to complete an experience questionnaire, to assess treatment experience.\n\nOnce the questionnaire is complete active participation in the trial is no longer needed, researchers will monitor participants notes for up to 12 months after treatment to record participant well being and function.",[95],"Metastatic Spinal Cord Compression",[97,98,99,100,101,102],"Radiotherapy","MR Linac","MSCC","CT Sim Free","One Stop","MR Guided","2025-11-25",{"date":105,"type":106},"2025-12-02","ACTUAL",{"date":108,"type":106},"2025-11-04",{"date":110,"type":89},"2028-11-04",{"name":5,"class":6},1]