[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100630880":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":37,"centralContacts":38,"locations":44,"responsibleParty":102,"collaborators":105,"id":115,"slug":116,"hasResults":117,"nctId":118,"briefTitle":119,"officialTitle":120,"acronym":37,"eligibilityCriteria":121,"healthyVolunteers":117,"sex":122,"minAge":123,"maxAge":37,"enrollmentInfo":124,"targetDuration":37,"studyType":127,"phases":128,"briefSummary":130,"conditions":131,"keywords":134,"overallStatus":90,"whyStopped":37,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":149},{"fullName":5,"class":6},"Unidade Local de Saúde São João","OTHER_GOV",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental arm","EXPERIMENTAL","Pancreatectomy, combined with complete cytoreduction and HIPEC",[13,14,15],"Procedure: Pancreatectomy","Procedure: Complete Cytoreduction","Other: Hyperthermic Intraperitoneal Chemotherapy (HIPEC)",[17,26,32],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":22},"PROCEDURE","Pancreatectomy","Total pancreatectomy for head tumours or radical antegrade modular pancreatosplenectomy (RAMPS) for distal tumours",[9],[23,24,25],"Total pancreatectomy","Radical Antegrade Modular Pancreatosplenectomy","RAMPS",{"type":18,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"Complete Cytoreduction","Resection of all macroscopic peritoneal metastases, but also the greater and lesser omentum, the round ligament of the liver, the appendix and the ovaries, in case of female patients",[9],[31],"CRS",{"type":33,"name":34,"description":35,"armGroupLabels":36,"otherNames":37},"OTHER","Hyperthermic Intraperitoneal Chemotherapy (HIPEC)","HIPEC with Cisplatin (100 mg\u002Fm2) and Paclitaxel (175 mg\u002Fm2) is performed for 90 minutes in a closed fashion",[9],null,[39],{"name":40,"role":41,"phone":42,"phoneExt":37,"email":43},"Tiago Bouça-Machado, MD","CONTACT","+351 225 512 100","tiago.machado@chsj.min-saude.pt",[45,70,88],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Zhongshan Hospital, Fudan University","NOT_YET_RECRUITING","Shanghai","shangaiShanghai Municipality","200000","China","CN",{"type":54,"coordinates":55},"Point",[56,57],121.45806,31.22222,{"lat":57,"lon":56},[60,64,67],{"name":61,"role":41,"phone":62,"phoneExt":37,"email":63},"Yaolin Xu","8618817583729","xu.yaolin@zs-hospital.sh.cn",{"name":65,"role":66,"phone":37,"phoneExt":37,"email":37},"Liang Liu, Dr.","PRINCIPAL_INVESTIGATOR",{"name":68,"role":69,"phone":37,"phoneExt":37,"email":37},"Yaolin Xu, Dr.","SUB_INVESTIGATOR",{"facility":71,"status":47,"city":72,"state":73,"zip":74,"country":75,"countryCode":76,"cosmosGeoPoint":77,"geoPoint":81,"contacts":82},"Botton\u002FChamaplimaud Pancreatic cancer center","Lisbon","Lisbon District","1400-038","Portugal","PT",{"type":54,"coordinates":78},[79,80],-9.1498,38.72509,{"lat":80,"lon":79},[83,87],{"name":84,"role":41,"phone":85,"phoneExt":37,"email":86},"Gil Gonçalves, MD","+351919362204","Gil.goncalves@fundacaochampalimaud.pt",{"name":84,"role":66,"phone":37,"phoneExt":37,"email":37},{"facility":89,"status":90,"city":91,"state":37,"zip":92,"country":75,"countryCode":76,"cosmosGeoPoint":93,"geoPoint":97,"contacts":98},"ULS São João","RECRUITING","Porto","4200-319",{"type":54,"coordinates":94},[95,96],-8.61097,41.1485,{"lat":96,"lon":95},[99,100,101],{"name":40,"role":41,"phone":42,"phoneExt":37,"email":43},{"name":37,"role":41,"phone":37,"phoneExt":37,"email":43},{"name":40,"role":66,"phone":37,"phoneExt":37,"email":37},{"type":66,"investigatorFullName":103,"investigatorTitle":104,"investigatorAffiliation":5,"oldNameTitle":37,"oldOrganization":37},"Tiago Bouça-Machado","MD",[106,108,111,113],{"name":107,"class":33},"Universitätsklinikum Hamburg-Eppendorf",{"name":109,"class":110},"The Champalimaud Centre, Lisbon, Portugal","UNKNOWN",{"name":112,"class":33},"Leiden University Medical Center",{"name":114,"class":33},"Shanghai Zhongshan Hospital","100630880","to-evaluate-the-feasibility-and-safety-of-combining-surgery-pancreatectomy-and-cytoreduction-with-hipec-for-treating-pancreatic-cancer-with-peritoneal-involvement-100630880",false,"NCT07493421","To Evaluate the Feasibility and Safety of Combining Surgery (Pancreatectomy and Cytoreduction) With HIPEC for Treating Pancreatic Cancer With Peritoneal Involvement.","Cytoreductive Surgery and HIPEC for Pancreatic Cancer With Peritoneal Metastasis - IGNIS Trial","Inclusion Criteria:\n\n* Pancreatic adenocarcinoma\n* Histologically confirmed peritoneal metastasis\n* Excluded other sites of metastasis (except ovary)\n* PCI less than or equal to 6\n* Age \\> 18 years\n* ECOG performance status 0-1\n* Written informed consent\n\nExclusion Criteria:\n\n* Pregnancy\n* Intestinal obstruction\n* Renal insufficiency (GFR \\\u003C 45 ml\u002Fmin)","ALL","18 Years",{"count":125,"type":126},20,"ESTIMATED","INTERVENTIONAL",[129],"NA","The goal of this clinical trial is to evaluate the safety and feasibility of a combined surgical and chemotherapy approach (pancreatectomy with cytoreductive surgery and HIPEC) in patients aged 18 and older with pancreatic ductal adenocarcinoma and synchronous peritoneal metastases. The main questions it aims to answer are:\n\nIs the 90-day mortality rate for this intensive combined procedure lower than 5%? What are the postoperative morbidity and complication rates (as measured by the Clavien-Dindo classification) for these patients? How does this treatment impact the patient's quality of life 12 months after the procedure?\n\nParticipants will:\n\nComplete at least 6 months of systemic chemotherapy to ensure the disease is stable or responding (biomarker CA19-9 must decline by \\>20%).\n\nUndergo a major surgical procedure involving the removal of the pancreatic tumour (total Pancreatectomy or RAMPS) and any visible abdominal metastases (Cytoreductive Surgery).\n\nReceive Hyperthermic Intraperitoneal Chemotherapy (HIPEC), where heated Cisplatin and Paclitaxel are circulated in the abdominal cavity for 90 minutes during the operation.\n\nParticipate in long-term follow-up to monitor recurrence-free and overall survival.",[132,133],"Pancreatic Adenocarcinoma","Peritoneal (Metastatic) Cancer",[135,136,137,138,139],"Pancreatic Cancer","Cytoreduction Surgical Procedures","Hyperthermic Intraperitoneal Chemotherapy","Peritoneal Metastasis","Peritoneal Carcinomatosis","2026-03-20",{"date":142,"type":143},"2026-03-25","ACTUAL",{"date":145,"type":143},"2026-03-01",{"date":147,"type":126},"2028-10-01",{"name":5,"class":6},3]