[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100559481":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":10,"centralContacts":27,"locations":10,"responsibleParty":33,"collaborators":36,"id":40,"slug":41,"hasResults":42,"nctId":43,"briefTitle":44,"officialTitle":44,"acronym":10,"eligibilityCriteria":45,"healthyVolunteers":46,"sex":47,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":10,"studyType":53,"phases":10,"briefSummary":54,"conditions":55,"keywords":10,"overallStatus":61,"whyStopped":10,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":10},{"fullName":5,"class":6},"Fujian University of Traditional Chinese Medicine","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Dysphagia in the oral phase after stroke",null,"The swallowing function was assessed by swallowing related scale and the Videofluoroscopic Swallowing Study, and then functional magnetic resonance imaging was performed.",[13],"Diagnostic Test: Swallowing function test",{"label":15,"type":10,"description":16,"interventionNames":17},"Without dysphagia after stroke","First, the swallowing function related scale was evaluated, and then the functional magnetic resonance imaging (fMRI) scan was performed.",[13],{"label":19,"type":10,"description":16,"interventionNames":20},"Healthy controls",[13],[22],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":10},"DIAGNOSTIC_TEST","Swallowing function test","The oral function score assesses the oral functional performance of chewing in all participants.\n\nThe Functional oral feeding Scale (FOIS) was used to assess the ability of all participants to eat.\n\nThe standardized swallowing assessment (SSA) was used to assess the global swallowing function of all participants.",[9,19,15],[28],{"name":29,"role":30,"phone":31,"phoneExt":10,"email":32},"Qingqing Zhang","CONTACT","18150019719","2017013@fjtcm.edu.cn",{"type":34,"investigatorFullName":29,"investigatorTitle":35,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","lecturer",[37],{"name":38,"class":39},"Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science","OTHER_GOV","100559481","to-explore-the-functional-connectivity-pattern-of-cortical-swallowing-network-in-the-oral-phase-of-post-stroke-dysphagia-based-on-dynamic-causal-modelling-100559481",false,"NCT06564688","To Explore the Functional Connectivity Pattern of Cortical Swallowing Network in the Oral Phase of Post-stroke Dysphagia Based on Dynamic Causal Modelling","Inclusion Criteria:\n\n1. Inclusion criteria of patients with post-stroke oral dysphagia:\n\n   * Patients with dysphagia after first stroke, meeting the diagnostic criteria of stroke, and confirmed by brain CT or brain MRI;\n   * Oral dysphagia caused by stroke;\n   * FOIS level ≤ 5; WST level ≥3;\n   * Those who can understand and carry out the simple instructions of the treatment staff and are willing to accept the examination and treatment;\n   * Clear consciousness and stable vital signs;\n   * Patients in the recovery stage with stroke course and dysphagia duration between 0 and 6 months;\n   * Right-handed;\n   * Voluntary participants with informed consent.\n2. Inclusion criteria of patients without dysphagia after stroke:\n\n   * Patients with first-ever stroke, meeting the diagnostic criteria of stroke, and confirmed by brain CT or brain MRI;\n   * No dysphagia, FOIS level =7; WST level =1;\n   * Those who can understand and carry out the simple instructions of the treatment staff and are willing to accept the examination and treatment;\n   * Clear consciousness and stable vital signs;\n   * Patients in the recovery stage with stroke duration between 0 and 6 months;\n   * Right-handed;\n   * Voluntary participants with informed consent.\n3. Inclusion criteria of healthy control group:\n\n   * Normal cognitive function and swallowing function, FOIS level =7; WST level =1;\n   * Gender and age matched with patients with dysphagia in the oral phase after stroke;\n   * Right-handed;\n   * Voluntary participants with informed consent.\n\nExclusion Criteria:\n\n* Dysphagia not caused by stroke or non-oral dysphagia;\n* History of cerebral trauma, stroke, brain tumor, cerebrovascular, intracranial infection, Parkinson's disease, epilepsy, or other neurological or psychiatric diseases;\n* Symptoms of severe aphasia, neglect, visual field defect and other cortical lesions; Patients with severe cognitive impairment or depression;\n* Taking or within 2 weeks of taking drugs that affect the nervous system or psychoses;\n* Patients with metal implants and\u002For spatial claustrophobia who are not suitable for MRI scanning;\n* Visual\u002Fhearing disorders affecting training and assessment;\n* Persons who are participating in other research trials that may influence the results of this study.",true,"ALL","18 Years","80 Years",{"count":51,"type":52},72,"ESTIMATED","OBSERVATIONAL","Swallowing activity in the oral phase is regulated by the cortical swallowing network, and the functional connectivity pattern of the cortical swallowing network is related to swallowing activity. The structural damage of the cortical swallowing network and abnormal activation of brain areas related to swallowing in post-stroke dysphagia affect swallowing activity. The recovery of dysphagia after stroke is related to the compensation of swallowing network in the contralateral hemisphere and different connectivity patterns of diseased brain areas, and the integrity of cortical swallowing network connectivity affects the sequence of oral swallowing activities. However, it is not clear how the functional connectivity patterns and interactions of brain regions of the cortical swallowing network related to oral swallowing activity change in patients with oral dysphagia after stroke.",[56,57,58,59,60],"Dysphagia After Stroke","Cortical Swallowing Network","Functional Magnetic Resonance Imaging","Oral Phase","Dynamic Causal Modelling","NOT_YET_RECRUITING","2024-08-19",{"date":64,"type":65},"2024-08-21","ACTUAL",{"date":67,"type":52},"2024-08-20",{"date":69,"type":52},"2025-07-01",{"name":5,"class":6}]