[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100599539":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":29,"locations":35,"responsibleParty":56,"collaborators":26,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":26,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":26,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":38,"whyStopped":26,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Institute of Liver and Biliary Sciences, India","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Plasmalyte","ACTIVE_COMPARATOR","Intravenous fluid plasmalyte.",[13],"Other: Plasmalyte",{"label":15,"type":16,"description":17,"interventionNames":18},"Pentoxifylline group","EXPERIMENTAL","Intravenous injection Pentoxifylline",[19],"Drug: Pentoxifylline (also known as oxpentifylline)",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Pentoxifylline (also known as oxpentifylline)","Intravenous injection Pentoxifylline 1 mg\u002Fkg\u002Fhr dissolved in Plasma Lyte\u002F0.9% Normal saline from12 hours before the surgery to 72 hours after the Surgery",[15],null,{"type":6,"name":9,"description":9,"armGroupLabels":28,"otherNames":26},[9],[30],{"name":31,"role":32,"phone":33,"phoneExt":26,"email":34},"Parneet Dr","CONTACT","+917888524169","parneet.sunam@gmail.com",[36],{"facility":37,"status":38,"city":39,"state":26,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Institute of Liver and Biliary Sciences","RECRUITING","New Delhi","110070","India","IN",{"type":44,"coordinates":45},"Point",[46,47],77.2148,28.62137,{"lat":47,"lon":46},[50,52],{"name":31,"role":32,"phone":51,"phoneExt":26,"email":34},"+917888524159",{"name":53,"role":32,"phone":54,"phoneExt":26,"email":55},"Nilesh S Patil, MBBS, MS, M Ch","+919540947478","dr.nils.p@gmail.com",{"type":57,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100599539","to-study-effect-of-injection-pentoxifylline-on-liver-growth-after-major-liver-surgery-100599539",false,"NCT07085806","To Study Effect of Injection Pentoxifylline on Liver Growth After Major Liver Surgery","Effect of Pentoxifylline on Liver Regeneration After Right Lobe Donor Hepatectomy: A Randomized Control Trial","Inclusion Criteria:\n\n* All live donors undergoing Right Donor Hepatectomy after ethical board clearance in the Department of HPB Surgery and Liver Transplantation\n\nExclusion Criteria:\n\n* Negative consent Hypersensitivity to Pentoxifylline","ALL","18 Years","55 Years",{"count":69,"type":70},60,"ESTIMATED","INTERVENTIONAL",[73],"NA","Posthepatectomy liver failure (PHLF) remains a significant life-threatening problem after major hepatectomies. Pentoxifylline is shown to have potent vasodilating properties for peripheral blood vessels, along with the hepatic vasculature. In a Double-blinded, randomized, controlled trial (RCT) at a single tertiary care center (2006-2009) by Petrowsky, Henrik et al (Annals of Surgery, November 2010) on 101 Non-cirrhotic patients undergoing major Hepatectomy, they demonstrated beneficial effects of Pentoxifylline on regeneration of small remnant livers (RLBW ratio ≤ 1.2%). In mice model, pentoxifylline (Tian, Yinghua, et al Proceedings of the National Academy of Sciences 103.12 (2006)) is shown to confer protective effects against small-for-size syndrome in arterialized small-for-size liver transplantation. This Randomised control trial is being conducted to analyze the effect of Pentoxifylline supplementation in live donors undergoing donor hepatectomy with respect to markers of anatomical regeneration in a high volume liver transplant center in India.",[76],"Liver Regeneration",[78],"Role of Injection pentoxifylline in Liver regeneration after Right lobe Hepatectomy","2025-07-18",{"date":81,"type":82},"2025-07-25","ACTUAL",{"date":84,"type":82},"2025-01-01",{"date":86,"type":70},"2025-07-31",{"name":5,"class":6},1]