[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100547327":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":33,"centralContacts":38,"locations":47,"responsibleParty":65,"collaborators":42,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":22,"eligibilityCriteria":75,"healthyVolunteers":71,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":42,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":87,"overallStatus":49,"whyStopped":42,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"University of Giessen","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"PRF site (test site)","EXPERIMENTAL","The participants become at least two teeth removed, one site is applied with PRF (test site) while the other is left for natural healing by forming a blood clot (control site). Operator and Investigator as well as the Patient are blinded to to the site of application.",[13],"Procedure: PRF",{"label":15,"type":16,"description":11,"interventionNames":17},"Blood clot (control site)","ACTIVE_COMPARATOR",[18],"Procedure: Natural Healing",[20,27],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","PRF","Patients blood is standardized centrifuged and split in to a red-phase (erythrocytes) and white-phase (PRF). The gained PRF is processed to a clot-fort and is inserted into the alveolus.",[9],[26],"Platelet rich fibrin",{"type":21,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Natural Healing","After the tooth extraction, natural healing is aimed by allowing a blood clot formation without any further intervention.",[15],[32],"Blood clot formation",[34],{"name":35,"affiliation":36,"role":37},"Sameh Attia, DDS, MSc","UKGM","STUDY_DIRECTOR",[39,44],{"name":35,"role":40,"phone":41,"phoneExt":42,"email":43},"CONTACT","‭(+49) 641 9946112‬",null,"Sameh.Attia@dentist.med.uni-giessen.de",{"name":45,"role":40,"phone":41,"phoneExt":42,"email":46},"Jan Nuernberg, DDS","jan.nuernberg@uk-gm.de",[48],{"facility":5,"status":49,"city":50,"state":51,"zip":42,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"RECRUITING","Giessen","Hesse","Germany","DE",{"type":55,"coordinates":56},"Point",[57,58],8.67554,50.58727,{"lat":58,"lon":57},[61],{"name":62,"role":40,"phone":63,"phoneExt":42,"email":64},"Sameh Attia, MSc","+49 176 80732647","Sameh.Attia@dentist.med.uni-gie",{"type":66,"investigatorFullName":67,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":42,"oldOrganization":42},"PRINCIPAL_INVESTIGATOR","Sameh Attia","Senior Physician in the department of Oral and Maxillofacial Surgery,PD, Dr. med. dent., M.Sc.","100547327","topical-application-of-prf-before-radiation-therapy-100547327",false,"NCT06406530","Topical Application of PRF Before Radiation Therapy","Topical Application of PRF in Tooth Extraction Sockets Before Radiation Therapy for Head and Neck Cancer","Inclusion Criteria:\n\n* Head and neck cancer with planed radiation therapy\n* Bilateral tooth extraction\n* Similar tooth size\n* Atraumatic tooth extractions without flap surgery\n* Patients age above 18y of age\n\nExclusion Criteria:\n\n* Prior radiation therapy in the head and neck area\n* Prior and current therapy with bisphosphonates or equivalent modern biologics\n* Patients during pregnancy or breastfeeding","ALL","18 Years","99 Years",{"count":80,"type":81},34,"ESTIMATED","INTERVENTIONAL",[84],"NA","The primary goal of this study is to observe whether PRP promotes the wound healing before a radiation therapy or not, compared to the natural healing of a tooth extraction socket.\n\nSecondary aim is to monitore the effect on the pain perception.",[22],[22,88,89,90,91,92],"wound healing","dentistry","oral surgery","radiation therapy","cancer","2025-04-08",{"date":95,"type":96},"2025-04-11","ACTUAL",{"date":98,"type":96},"2023-12-01",{"date":100,"type":81},"2025-09-01",{"name":5,"class":6},1]