[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100597378":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":39,"locations":46,"responsibleParty":63,"collaborators":44,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":44,"eligibilityCriteria":72,"healthyVolunteers":68,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":44,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":44,"overallStatus":89,"whyStopped":44,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Second Hospital of Jilin University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Total Arterial Grafting Group","EXPERIMENTAL","Patients in this group will undergo coronary artery bypass grafting (CABG) with total arterial grafts to the left coronary artery system. The left internal thoracic artery (LITA) will be grafted to the left anterior descending artery (LAD), and the radial artery will be anastomosed to the obtuse marginal or diagonal branches of the circumflex artery. The right coronary artery, if revascularized, will receive a conventional vein graft.",[13],"Procedure: Total Arterial Grafting",{"label":15,"type":16,"description":17,"interventionNames":18},"Conventional Mixed Grafting Group","ACTIVE_COMPARATOR","Patients in this group will receive conventional mixed grafting during CABG. The left internal thoracic artery (LITA) will be used for the LAD, while the great saphenous vein will be grafted to other branches of the left coronary artery system, such as the obtuse marginal or diagonal branches. The right coronary artery, if revascularized, will also be grafted using a vein.",[19],"Procedure: Conventional Mixed Grafting",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Total Arterial Grafting","Coronary artery bypass grafting using only arterial conduits in the left coronary artery system. The left internal thoracic artery (LITA) is grafted to the LAD, and the radial artery is anastomosed to the obtuse marginal or diagonal branches. This approach avoids the use of saphenous vein grafts for the left coronary system.",[9],[27],"LITA + Radial Artery Grafting",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Conventional Mixed Grafting","A standard coronary artery bypass grafting (CABG) procedure where the left internal thoracic artery (LITA) is grafted to the LAD, and saphenous vein grafts are used for the obtuse marginal or diagonal branches of the left coronary system. This approach represents the conventional mixed arterial-venous strategy.",[15],[33],"Mixed Arterial-Venous Grafting",[35],{"name":36,"affiliation":37,"role":38},"Kexiang Liu","Department of Cardiovascular Surgery, The Second Hospital of Jilin University","PRINCIPAL_INVESTIGATOR",[40],{"name":41,"role":42,"phone":43,"phoneExt":44,"email":45},"kexiang liu","CONTACT","17390920328",null,"kxliu64@hotmail.com",[47],{"facility":48,"status":44,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"The Second Hospital of Jilin University","Changchun","Jilin","130000","China","CN",{"type":55,"coordinates":56},"Point",[57,58],125.32278,43.88,{"lat":58,"lon":57},[61],{"name":62,"role":42,"phone":44,"phoneExt":44,"email":44},"kexiang liu, Ph.D.",{"type":38,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":44,"oldOrganization":44},"Kexiang Liu, MD","Principal Investigator","100597378","total-arterial-vs-mixed-grafting-in-left-coronary-cabg-100597378",false,"NCT07057713","Total Arterial vs. Mixed Grafting in Left Coronary CABG","A Prospective, Randomized, Double-Blind Controlled Trial Comparing Total Arterial Grafting Versus Conventional Mixed Grafting in the Left Coronary Artery System During Coronary Artery Bypass Grafting (CABG)","Inclusion Criteria:\n\n1. Age ≥ 18 years\n2. Diagnosed with multivessel coronary artery disease\n3. Indicated for elective coronary artery bypass grafting (CABG) involving ≥3 coronary vessels\n4. Right coronary artery stenosis \\>75%\n5. Able and willing to provide written informed consent\n\nExclusion Criteria:\n\n1. Scheduled for concurrent cardiac procedures (e.g., valve surgery, congenital heart disease repair, aortic dissection surgery, atrial fibrillation ablation)\n2. Severe stenosis of left or right subclavian artery\n3. Unsuitable saphenous veins (e.g., bilateral varicosities)\n4. Unsuitable radial artery as assessed preoperatively\n5. History of intracranial hemorrhage or ischemic stroke within the past 14 days\n6. Severe hepatic or renal insufficiency\n7. Acute myocardial infarction within 72 hours prior to surgery\n8. History of prior CABG or other cardiac surgery","ALL","18 Years","80 Years",{"count":77,"type":78},400,"ESTIMATED","INTERVENTIONAL",[81],"NA","This is a prospective, randomized, double-blind controlled trial comparing the clinical efficacy of total arterial grafting (internal thoracic artery and radial artery) versus conventional mixed grafting (internal thoracic artery and great saphenous vein) in the left coronary artery system during coronary artery bypass grafting (CABG). A total of 400 patients undergoing elective CABG at the Second Hospital of Jilin University will be enrolled and randomized into two groups. The primary endpoint is graft patency at 12 months postoperatively, evaluated by coronary angiography or CT angiography. Secondary outcomes include perioperative complications, major adverse cardiovascular events (MACE), and long-term clinical prognosis. The study aims to provide evidence-based guidance on optimal graft selection in CABG.",[84,85,86,87,88],"Coronary Artery Disease","Coronary Artery Bypass Grafting","Arterial Graft","Graft Patency","Major Adverse Cardiovascular Events","NOT_YET_RECRUITING","2026-04-21",{"date":92,"type":93},"2026-04-23","ACTUAL",{"date":95,"type":78},"2026-08-01",{"date":97,"type":78},"2027-12-30",{"name":5,"class":6},1]