[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100601063":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":43,"centralContacts":48,"locations":57,"responsibleParty":73,"collaborators":36,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":36,"eligibilityCriteria":81,"healthyVolunteers":77,"sex":82,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":36,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":36,"overallStatus":60,"whyStopped":36,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"Zagazig University","OTHER_GOV",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Dexmedetomidine group","ACTIVE_COMPARATOR","Intravenous loading dose of dexmedetomidine 1 µg\u002Fkg over 10 minutes before propofol infusion, followed by an intraoperative maintenance infusion of 0.5 µg\u002Fkg\u002Fhour.",[13],"Drug: Dexmedetomidine",{"label":15,"type":10,"description":16,"interventionNames":17},"Fentanyl group","Intravenous loading dose of fentanyl 1 µg\u002Fkg over 10 minutes before propofol infusion, followed by an intraoperative maintenance infusion of 0.5 µg\u002Fkg\u002Fhour.",[18],"Drug: Fentanyl",{"label":20,"type":10,"description":21,"interventionNames":22},"Magnesium group","Magnesium sulphate 30-50 mg\u002Fkg intravenous over 15-30 minutes before propofol infusion, followed by intraoperative maintenance infusion of 10-20 mg\u002Fkg\u002Fhour.",[23],"Drug: Magnesium",[25,32,37],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DRUG","Dexmedetomidine","Dexmedetomidine as an adjunct to total intravenous anesthesia.",[9],[31],"Precedex",{"type":26,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"Fentanyl","Fentanyl as an adjunct to total intravenous anesthesia.",[15],null,{"type":26,"name":38,"description":39,"armGroupLabels":40,"otherNames":41},"Magnesium","Magnesium sulphate as an adjunct to total intravenous anesthesia.",[20],[42],"Magnesium sulphate",[44],{"name":45,"affiliation":46,"role":47},"Fatma Mahmoud Ahmed, MD","Department of Anesthesia, Intensive Care & Pain Management, Zagazig University","PRINCIPAL_INVESTIGATOR",[49,54],{"name":50,"role":51,"phone":52,"phoneExt":36,"email":53},"Sherif Mohammed Said Mowafy, MD","CONTACT","01003523374","sherifmowafy2012@gmail.com",{"name":55,"role":51,"phone":36,"phoneExt":36,"email":56},"Mohamed gaber, MD","mgmelsayed@medicine.zu.edu.eg",[58],{"facility":59,"status":60,"city":61,"state":36,"zip":36,"country":62,"countryCode":63,"cosmosGeoPoint":64,"geoPoint":69,"contacts":70},"Zagazig university hospital","RECRUITING","Zagazig","Egypt","EG",{"type":65,"coordinates":66},"Point",[67,68],31.502,30.58768,{"lat":68,"lon":67},[71],{"name":72,"role":51,"phone":36,"phoneExt":36,"email":56},"Mohamed mohamed, MD",{"type":74,"investigatorFullName":36,"investigatorTitle":36,"investigatorAffiliation":36,"oldNameTitle":36,"oldOrganization":36},"SPONSOR","100601063","total-intravenous-anesthesia-in-patients-undergoing-craniotomy-100601063",false,"NCT07105618","Total Intravenous Anesthesia in Patients Undergoing Craniotomy","Comparison of Dexmedetomidine Versus Fentanyl or Magnesium Sulphate as Adjuncts to Propofol-Based Total Intravenous Anesthesia in Patients Undergoing Craniotomy","Inclusion Criteria:\n\n* Patient acceptance.\n* Physical status: American Society of Anesthesiologists Physical Status (ASA) 1\\& II.\n* Body mass index ≤ 30 kg\u002Fm2.\n* Type of operation: elective craniotomy for brain tumor resection.\n* Duration of surgery: within 4 hours.\n\nExclusion Criteria:\n\n* Patient with hemodynamic instability or anticipated postoperative mechanical ventilation.\n* Patients with a known history of allergy to the study drugs.\n* Advanced hepatic, renal, cardiovascular, and neurologic diseases.\n* Patients with chronic opioid use.","ALL","21 Years","60 Years",{"count":86,"type":87},108,"ESTIMATED","INTERVENTIONAL",[90],"NA","Craniotomy presents true anesthetic challenges, mainly due to the need to optimize cerebral perfusion, facilitate brain relaxation, achieve rapid emergence for neurologic assessment, and minimize perioperative complications.",[93],"Anesthesia","2026-04-30",{"date":96,"type":97},"2026-05-06","ACTUAL",{"date":99,"type":97},"2025-08-10",{"date":101,"type":87},"2027-04",{"name":5,"class":6},1]