[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100629530":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":12,"locations":18,"responsibleParty":30,"collaborators":10,"id":34,"slug":35,"hasResults":36,"nctId":37,"briefTitle":38,"officialTitle":39,"acronym":40,"eligibilityCriteria":41,"healthyVolunteers":36,"sex":42,"minAge":43,"maxAge":44,"enrollmentInfo":45,"targetDuration":10,"studyType":48,"phases":10,"briefSummary":49,"conditions":50,"keywords":55,"overallStatus":60,"whyStopped":10,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":68,"locationsCount":69},{"fullName":5,"class":6},"Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Severe Limb Trauma With Tourniquet Exposure",null,"This cohort includes adult patients with severe upper or lower limb trauma who required tourniquet application for hemorrhage control in the prehospital or hospital setting. The study is observational and does not involve any study-mandated intervention. Clinical care will follow institutional trauma protocols. The primary exposure of interest is cumulative tourniquet duration (minutes). Participants will be followed prospectively to evaluate the association between tourniquet exposure and the development of persistent pain, neuropathic pain, functional outcomes, and quality of life up to 6 months after injury.",[13],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},"Dmytro Dmitriy Dmytriiev, PhD.Professor","CONTACT","+380674309449","d.dmytriiev@superhumans.com",[19],{"facility":20,"status":10,"city":21,"state":10,"zip":10,"country":22,"countryCode":23,"cosmosGeoPoint":24,"geoPoint":29,"contacts":10},"Superhumans War Trauma Center","Lviv","Ukraine","UA",{"type":25,"coordinates":26},"Point",[27,28],24.02324,49.83826,{"lat":28,"lon":27},{"type":31,"investigatorFullName":32,"investigatorTitle":33,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Dmytro Dmytriiev","Chief of science department, PhD, Professor","100629530","tourniquet-exposure-and-risk-of-chronic-pain-after-severe-limb-trauma-100629530",false,"NCT07475871","Tourniquet Exposure and Risk of Chronic Pain After Severe Limb Trauma","Tourniquet Exposure and Risk of Chronic Pain After Severe Limb Trauma: A Prospective Cohort Study","TOURNI-PAIN","Inclusion Criteria:\n\n* Age ≥18 years\n* Severe upper or lower limb trauma\n* Documented tourniquet use (prehospital or in-hospital)\n* Available documentation of tourniquet duration\n* Informed consent\n\nExclusion Criteria:\n\n* Pre-existing chronic limb pain\n* Known severe peripheral neuropathy\n* Cognitive inability to complete follow-up\n* Expected survival \\\u003C48 hours","ALL","18 Years","60 Years",{"count":46,"type":47},150,"ESTIMATED","OBSERVATIONAL","Severe limb trauma often requires the use of a tourniquet to stop life-threatening bleeding. While tourniquets are essential for saving lives, prolonged interruption of blood flow may lead to tissue ischemia, nerve injury, and inflammatory responses that could contribute to the development of chronic pain.\n\nThe TOURNI-PAIN Study is a prospective observational study designed to investigate whether the duration of tourniquet use during the treatment of severe limb injuries is associated with an increased risk of persistent pain after recovery. The study will enroll adult patients with major upper or lower limb trauma who required tourniquet application in the prehospital or hospital setting.\n\nResearchers will collect information about the duration and characteristics of tourniquet use, details of the injury, surgical treatment, and recovery. Participants will be followed for up to 6 months after injury to assess pain levels, possible neuropathic pain, functional recovery, and quality of life.\n\nThe goal of this research is to better understand whether longer tourniquet exposure increases the risk of long-term pain. The findings may help improve trauma care practices by balancing the life-saving benefits of hemorrhage control with strategies that minimize long-term complications and improve recovery for patients with severe limb injuries.",[51,52,53,54],"Pain","Pain After Surgery","Phantom Limb Pain After Amputation","Military Combat Stress Reaction",[56,57,58,59],"Tourniquet","Chronic Pain","Phantom Limb Pain","Trauma Rehabilitation","NOT_YET_RECRUITING","2026-03-16",{"date":63,"type":64},"2026-03-18","ACTUAL",{"date":66,"type":47},"2026-03-15",{"date":66,"type":47},{"name":5,"class":6},1]