[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100538622":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":26,"centralContacts":30,"locations":37,"responsibleParty":52,"collaborators":10,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":63,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":10,"studyType":70,"phases":10,"briefSummary":71,"conditions":72,"keywords":75,"overallStatus":39,"whyStopped":10,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"KK Women's and Children's Hospital","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Subfertile couples",null,"Couples who are not able to conceive for at least 12 months with female partners without infertility diagnosis.",[13],"Other: Lifestyle and metabolic indicators",{"label":15,"type":10,"description":16,"interventionNames":17},"Fertile couples","Couples with attempted time to conceive within 12 months to achieve this pregnancy or with unplanned pregnancy, with female partners who are currently pregnant with viable intrauterine pregnancy.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"OTHER","Lifestyle and metabolic indicators","Socio-demographics, health history, behavioural characteristics, environmental exposures, anthropometric measurements, body fat composition, metabolic and stress biomarkers, semen physical and molecular characteristics.",[15,9],[25],"Semen quality and characteristics",[27],{"name":28,"affiliation":5,"role":29},"See Ling Loy, PhD","PRINCIPAL_INVESTIGATOR",[31],{"name":32,"role":33,"phone":34,"phoneExt":35,"email":36},"Benjarat Oh","CONTACT","63948105","65","benjarat.oh@kkh.com.sg",[38],{"facility":5,"status":39,"city":40,"state":10,"zip":41,"country":40,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"RECRUITING","Singapore","229899","SG",{"type":44,"coordinates":45},"Point",[46,47],103.85007,1.28967,{"lat":47,"lon":46},[50],{"name":32,"role":33,"phone":51,"phoneExt":10,"email":36},"+6583684641",{"type":29,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Loy See Ling","Junior Principal Investigator","100538622","towards-optimal-fertility-fathering-and-fatherhood-study-100538622",false,"NCT06293235","Towards Optimal Fertility, Fathering and Fatherhood studY","Investigating Male Factors and Their Relationships With Reproductive Health Outcomes in Singapore: Towards Optimal Fertility, Fathering and Fatherhood studY","TOFFFY","Inclusion Criteria:\n\nSubfertile couples:\n\n* men aged ≥21-49 years\n* men with a female partner aged 21-39 years\n* couples who are not able to conceive for at least 12 months\n* couples who are Singapore citizen or permanent resident\n\nFertile couples:\n\n* men aged 21-49 years\n* men with a female partner aged 21-39 years\n* men with proven fertility defined as those female partners who are currently pregnant and with viable intrauterine pregnancy at gestational weeks of less or equal to 16 at the time of the study\n* couples with attempted time to conceive within 12 months to achieve this pregnancy or with unplanned pregnancy\n* couples who are Singapore citizen or permanent resident\n\nExclusion Criteria:\n\nSubfertile couples:\n\n* male infertility of a known aetiology including azoospermia, retrograde ejaculation, genetic disorders, cancer treatment, or testes trauma\n* female infertility diagnosis as confirmed by diagnostic imaging or having severe endometriosis\n* female partners with irregular menstrual cycle \\>35 days\n* couples with known chromosomal abnormalities\n\nFertile couples:\n\n* couples who achieve pregnancy after oocyte or spermatozoa donation\n* couples with known chromosomal abnormalities\n* female partners with known uterine abnormalities",true,"ALL","21 Years","49 Years",{"count":68,"type":69},960,"ESTIMATED","OBSERVATIONAL","This case-control study involving fertile and subfertile couples aims to identify male factors related to pregnancy likelihood, create a fertility index measure combining male and female factors to predict pregnancy likelihood, and examine how male factors relate to the semen physical and biological characteristics.",[73,74],"Reproductive Issues","Fertility Issues",[76,77,78,79,80,81,82],"Male","Risk factor","Lifestyle","Semen analysis","Epigenetic","Oxidative stress","DNA fragmentation","2026-03-17",{"date":85,"type":86},"2026-03-20","ACTUAL",{"date":88,"type":86},"2024-06-21",{"date":90,"type":69},"2027-09",{"name":5,"class":6},1]