[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642002":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":18,"centralContacts":23,"locations":33,"responsibleParty":72,"collaborators":74,"id":87,"slug":88,"hasResults":89,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":93,"eligibilityCriteria":94,"healthyVolunteers":89,"sex":95,"minAge":96,"maxAge":10,"enrollmentInfo":97,"targetDuration":10,"studyType":100,"phases":10,"briefSummary":101,"conditions":102,"keywords":107,"overallStatus":49,"whyStopped":10,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":121},{"fullName":5,"class":6},"Henry M. Jackson Foundation for the Advancement of Military Medicine","OTHER",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Cohort 1",null,"Active duty service members (ADSMs) and other Military Health System (MHS) beneficiaries who have a history of B-cell non-Hodgkin Lymphoma (NHL) and have achieved clinical remission.",{"label":13,"type":10,"description":14,"interventionNames":10},"Cohort 2","ADSMs and other MHS beneficiaries ages 18 and older who are newly diagnosed with B-cell NHL and\u002For are not undergoing active treatment.",{"label":16,"type":10,"description":17,"interventionNames":10},"Cohort 3","Other MHS beneficiaries ages 4-17 who are diagnosed with B-cell NHL and are treatment naive.",[19],{"name":20,"affiliation":21,"role":22},"Christin Destefano","Uniformed Services University of the Health Sciences","PRINCIPAL_INVESTIGATOR",[24,29],{"name":25,"role":26,"phone":27,"phoneExt":10,"email":28},"Christin B. Destefano, MD, Lt Col, MC, USAF","CONTACT","(301) 295-3190","christin.destefano@usuhs.edu",{"name":30,"role":26,"phone":31,"phoneExt":10,"email":32},"W. Grant Day, MD, LCDR, MC, USN","(757) 953-2194","william.g.day26.mil@health.mil",[34,47,62],{"facility":21,"status":35,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":10},"ACTIVE_NOT_RECRUITING","Bethesda","Maryland","20814","United States","US",{"type":42,"coordinates":43},"Point",[44,45],-77.10026,38.98067,{"lat":45,"lon":44},{"facility":48,"status":49,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":50,"geoPoint":52,"contacts":53},"Walter Reed National Military Medical Center","RECRUITING",{"type":42,"coordinates":51},[44,45],{"lat":45,"lon":44},[54,56,60],{"name":55,"role":26,"phone":27,"phoneExt":10,"email":28},"Christin B Destefano",{"name":57,"role":26,"phone":58,"phoneExt":10,"email":59},"Annika Hamann, RN, BSN, BS","(301) 295-4198","annika.hamann.ctr@usuhs.edu",{"name":61,"role":22,"phone":10,"phoneExt":10,"email":10},"Jeremy Perkins, MD, FACP, COL, US Army (ret)",{"facility":63,"status":35,"city":64,"state":65,"zip":66,"country":39,"countryCode":40,"cosmosGeoPoint":67,"geoPoint":71,"contacts":10},"Naval Medical Center Portsmouth","Portsmouth","Virginia","23708",{"type":42,"coordinates":68},[69,70],-76.29827,36.83543,{"lat":70,"lon":69},{"type":73,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[75,77,80,81,83,85],{"name":21,"class":76},"FED",{"name":78,"class":79},"Murtha Cancer Center","UNKNOWN",{"name":48,"class":76},{"name":82,"class":76},"United States Naval Medical Center, Portsmouth",{"name":84,"class":6},"Children's Hospital Medical Center, Cincinnati",{"name":86,"class":79},"The American Genome Center","100642002","toxin-exposure-and-immune-dysregulation-in-non-hodgkin-lymphoma-100642002",false,"NCT07652580","Toxin Exposure and Immune Dysregulation in Non-Hodgkin Lymphoma","Toxin Exposure and Immune Dysregulation in Non-Hodgkin Lymphoma Across the Military Healthcare System","TOXNHL","Inclusion Criteria:\n\n* Age 4 years old and older with a clinical diagnosis of B-cell NHL.\n* Must be willing to undergo phlebotomy and\u002For skin punch biopsy.\n* Must be willing to undergo whole genome sequencing, which includes return of primary and secondary findings.\n\nExclusion Criteria:\n\n* Has any condition that, in the opinion of the Principal Investigator, contraindicates participation in this study. Examples of situation that may contraindicate participation include but are not limited to a) some cases of cerebral vascular accidents where an individual no longer has the capacity to make their own medical decisions and a conservator or responsible family member is not available and b) an individual has active suicidal ideation and is a danger to themselves at the time of enrollment.\n* Does not have access to health care and primary care clinician.\n* Actively undergoing induction treatment for NHL.","ALL","4 Years",{"count":98,"type":99},300,"ESTIMATED","OBSERVATIONAL","The goal of this observational cohort study is to learn how toxin and occupational exposures, germline genetic variation, and immune dysregulation relate to B-cell non-Hodgkin lymphoma among active-duty service members and other Military Health System beneficiaries. The main questions are whether specific exposures and germline variants are associated with B-cell NHL subtype, immune dysfunction, and clinical outcomes. Participants will complete exposure and medical-history surveys, provide biospecimens for immune and genomic testing, and may be followed annually for up to 3 years.",[103,104,105,106],"Non-Hodgkin Lymphoma","Lymphoma Non-Hodgkin","B-cell Lymphoma","Immune Dysregulation",[108,109,110,111],"Immunodeficiency","Lymphoma","Exposure","Genetics","2026-06-11",{"date":114,"type":115},"2026-06-17","ACTUAL",{"date":117,"type":115},"2025-05-01",{"date":119,"type":99},"2028-05-01",{"name":5,"class":6},3]