[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100402718":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":10,"centralContacts":19,"locations":25,"responsibleParty":42,"collaborators":10,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":48,"sex":54,"minAge":55,"maxAge":10,"enrollmentInfo":56,"targetDuration":59,"studyType":60,"phases":10,"briefSummary":61,"conditions":62,"keywords":10,"overallStatus":28,"whyStopped":10,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":75},{"fullName":5,"class":6},"Radboud University Medical Center","OTHER",[8],{"label":9,"type":10,"description":10,"interventionNames":11},"Thoracic aortic surgery patients",null,[12],"Diagnostic Test: Trajectory of neuroinflammatory proteins in CSF and blood",[14],{"type":15,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"DIAGNOSTIC_TEST","Trajectory of neuroinflammatory proteins in CSF and blood","Kinetics of neuroinflammatory markers in CSF and blood",[9],[20],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},"Wilson F. Abdo, MD, PhD","CONTACT","+31243617273","f.abdo@radboudumc.nl",[26],{"facility":27,"status":28,"city":29,"state":10,"zip":30,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"Department of Intensive Care Medicine, Radboud university medical center","RECRUITING","Nijmegen","6500HB","Netherlands","NL",{"type":34,"coordinates":35},"Point",[36,37],5.85278,51.8425,{"lat":37,"lon":36},[40],{"name":21,"role":22,"phone":41,"phoneExt":10,"email":24},"0243617273",{"type":43,"investigatorFullName":44,"investigatorTitle":45,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Wilson F. Abdo","Principal Investigator","100402718","trajectory-of-neuroinflammatory-markers-in-cerebrospinal-fluid-prior-to-and-after-thoracic-aortic-surgery-100402718",false,"NCT04523909","Trajectory of Neuroinflammatory Markers in Cerebrospinal Fluid Prior to and After Thoracic Aortic Surgery","Trajectory of Neuroinflammatory Markers in Cerebrospinal Fluid Prior to and After Thoracic Aortic Surgery: the TURBO Study","TURBO","Inclusion Criteria:\n\n* Competent patients ≥ 18 years\n* Patients who will undergo thoracic aortic surgery and will therefore receive an external lumbar drain as a standard of care procedure.\n\nExclusion Criteria:\n\n* Patients with meningitis\u002Fencephalitis\u002Fbrain abscess within the last 6 months\n* Patients with other neurological conditions: brain injury (acute stroke, brain trauma or cerebral haemorrhage) within the last 3 months, known brain tumours, neurodegenerative disease or known pre-existing cognitive impairment (to a degree that would be compatible with mild cognitive impairment or more).\n* Brain or spinal surgery within the last 3 months\n* Active infection \\\u003C2 weeks before surgery\n* Patients who object against storage of their body material for scientific reasons","ALL","18 Years",{"count":57,"type":58},100,"ESTIMATED","2 Weeks","OBSERVATIONAL","Observational prospective pilot study to analyze the trajectory of neuroinflammatory protein expression in cerebrospinal fluid (CSF) in relation to systemic compartment in patients undergoing thoracic aortic surgery.\n\nThe aim of this study is to identify and unravel the biochemical (neuroinflammatory) pathways involved in postoperative delirium.\n\nPatient undergoing thoracic aortic surgery will have an external lumbar drain (ELD) in situ on the day before surgery. This ELD remains in place during and three days after surgery to reduce the risk on periprocedural spinal cord ischemia. Paired measurements of CSF and blood will be analyzed.",[63,64,65],"Postoperative Delirium","Postoperative Cognitive Dysfunction","Thoracic Aortic Aneurysm","2023-03-28",{"date":68,"type":69},"2023-03-31","ACTUAL",{"date":71,"type":69},"2017-12-18",{"date":73,"type":58},"2026-12-01",{"name":5,"class":6},1]