[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100609711":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":59,"collaborators":26,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":26,"enrollmentInfo":72,"targetDuration":26,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":92,"overallStatus":39,"whyStopped":26,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"Washington University School of Medicine","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Auricular vagal nerve stimulation","EXPERIMENTAL","Participants will receive vagal nerve stimulation twice on the day of surgery (once preoperatively) and twice daily postoperatively for duration of hospitalization.\n\nAll patients will be fitted with the device via adhesive contacts to the left ear. Stimulation will occur for 20 minutes per session. The intervention will provide stimulation according to the following parameters: frequency 20 Hz, pulse width 250 µm, and fixed intensity of 0.5 milliampere. The amplitude of stimulation may be reduced if a patient complains of discomfort at the site of stimulation",[13],"Device: Auricular vagus nerve stimulation",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham vagal nerve stimulation","SHAM_COMPARATOR","Participants will have an auricular vagal nerve stimulator device applied in the same manner as the experimental arm, but they will not receive the actual stimulation.",[19],"Device: Sham Auricular Vagus nerve Stimulation",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Auricular vagus nerve stimulation","Transcutaneous auricular vagal nerve stimulation",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Sham Auricular Vagus nerve Stimulation","Transcutaneous auricular vagal nerve stimulator applied without utilizing stimulating current.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Alexander T Yahanda, MD, MPHS","CONTACT","3143690198","ayahanda@wustl.edu",[38],{"facility":5,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"RECRUITING","St Louis","Missouri","63110","United States","US",{"type":46,"coordinates":47},"Point",[48,49],-90.19789,38.62727,{"lat":49,"lon":48},[52,54,57],{"name":33,"role":34,"phone":53,"phoneExt":26,"email":36},"2604946828",{"name":55,"role":56,"phone":26,"phoneExt":26,"email":26},"Eric C Leuthardt, MD","PRINCIPAL_INVESTIGATOR",{"name":58,"role":56,"phone":26,"phoneExt":26,"email":26},"Camilo A Molina, MD",{"type":60,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"SPONSOR_INVESTIGATOR","Alexander T. Yahanda","Neurosurgery Resident","100609711","trans-auricular-stimulation-for-postoperative-inflammation-in-spine-surgery-100609711",false,"NCT07218133","Trans-Auricular Stimulation for Postoperative Inflammation in Spine Surgery","TAPIS","Inclusion Criteria:\n\n* Long-segment spinal fusions (defined as constructs spanning at least L2-pelvis for thoracolumbar fusions or C2-T2 for cervical fusions)\n* Ability to undergo a reliable neurologic examination and pain assessments\n\nExclusion Criteria:\n\n* Patients \\\u003C18 years of age\n* Shorter-segment spinal fusions than those described above\n* Undergoing current active cancer therapy\n* Undergoing treatment with immunosuppressive drugs\n* Additional spinal surgery within past 6 months\n* Sustained bradycardia or presence of pacemaker\n* History of substance abuse","ALL","18 Years",{"count":73,"type":74},50,"ESTIMATED","INTERVENTIONAL",[77],"NA","This study is a randomized controlled trial that will evaluate the effect of non-invasive auricular vagal nerve stimulation on inflammatory markers, glycemic control, postoperative pain, and inflammation-related clinical outcomes after long-segment spinal fusion surgeries when compared to current accepted management.",[80,81,82,83,84,85,86,87,88,89,90,91],"Spinal Fusion","Hyperglycemia","Postoperative Pain Management","Postoperative Care","Spine Disease","Neurologic Deficits","Neurological Disorder","Inflammation","Spine Condition","Spinal (Fusion) Surgery","Cytokine Levels","Spine Fusion",[93,94,95,96,97,98,99,100],"spinal fusion","postoperative pain","glycemic control","inflammation","vagal nerve stimulation","postoperative complications","cytokine","spine surgery","2026-02-17",{"date":103,"type":104},"2026-02-20","ACTUAL",{"date":106,"type":104},"2025-10-08",{"date":108,"type":74},"2026-12",{"name":61,"class":6},1]