[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100283201":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":33,"centralContacts":38,"locations":45,"responsibleParty":267,"collaborators":270,"id":301,"slug":302,"hasResults":303,"nctId":304,"briefTitle":305,"officialTitle":306,"acronym":43,"eligibilityCriteria":307,"healthyVolunteers":303,"sex":308,"minAge":309,"maxAge":310,"enrollmentInfo":311,"targetDuration":43,"studyType":314,"phases":315,"briefSummary":317,"conditions":318,"keywords":321,"overallStatus":48,"whyStopped":43,"lastUpdateSubmitDate":327,"lastUpdatePostDateStruct":328,"startDateStruct":331,"completionDateStruct":333,"leadSponsor":335,"locationsCount":336},{"fullName":5,"class":6},"Sun Yat-sen University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Transanal Total Mesorectal Excision","EXPERIMENTAL","The rectum is mobilized and resected transanally (from bottom to up) according to TME principles, via transanal platform (either rigid or flexible platform).An ideal TaTME is defined as the extraperitoneal portion of the rectum being mobilized from below.",[13],"Procedure: TaTME",{"label":15,"type":16,"description":17,"interventionNames":18},"Laparoscopic Total Mesorectal Excision","ACTIVE_COMPARATOR","The traditional laparoscopic TME (LpTME) was performed via standard laparoscopic techniques, including multiple trocars and conventional laparoscopic instruments.",[19],"Procedure: LpTME",[21,27],{"type":22,"name":23,"description":9,"armGroupLabels":24,"otherNames":25},"PROCEDURE","TaTME",[9],[26],"Transanal TME",{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"LpTME","Conventional Laparoscopic Total Mesorectal Excision",[15],[32],"Laparoscopic TME",[34],{"name":35,"affiliation":36,"role":37},"Jianping Wang, MD,PHD","The Sixth Affiliated Hospital, Sun Yat-sen University","PRINCIPAL_INVESTIGATOR",[39],{"name":40,"role":41,"phone":42,"phoneExt":43,"email":44},"Liang Kang, MD,PHD","CONTACT","008613602886833",null,"eonkang@163.com",[46,65,80,91,100,114,129,142,156,171,186,201,216,227,242,256],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Department of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences","RECRUITING","Beijing","Beijing Municipality","100730","China","CN",{"type":55,"coordinates":56},"Point",[57,58],116.39723,39.9075,{"lat":58,"lon":57},[61],{"name":62,"role":41,"phone":63,"phoneExt":43,"email":64},"Yi Xiao, MD, PhD","008613366036387","XiaoY@pumch.cn",{"facility":66,"status":48,"city":67,"state":68,"zip":69,"country":52,"countryCode":53,"cosmosGeoPoint":70,"geoPoint":74,"contacts":75},"Department of General Surgery, Daping Hospital, Army Medical university","Chongqing","Chongqing Municipality","400042",{"type":55,"coordinates":71},[72,73],106.55771,29.56026,{"lat":73,"lon":72},[76],{"name":77,"role":41,"phone":78,"phoneExt":43,"email":79},"Weidong Tong, MD, PhD","008613500321218","vdtong@163.com",{"facility":81,"status":82,"city":83,"state":84,"zip":85,"country":52,"countryCode":53,"cosmosGeoPoint":86,"geoPoint":90,"contacts":43},"Department of colorectal surgery, the Sixth Affiliated Hospital, Sun Yat-Sen University","COMPLETED","Guangzhou","Guangdong","510000",{"type":55,"coordinates":87},[88,89],113.25,23.11667,{"lat":89,"lon":88},{"facility":92,"status":48,"city":83,"state":84,"zip":93,"country":52,"countryCode":53,"cosmosGeoPoint":94,"geoPoint":96,"contacts":97},"Nanfang Hospital","510559",{"type":55,"coordinates":95},[88,89],{"lat":89,"lon":88},[98],{"name":99,"role":41,"phone":43,"phoneExt":43,"email":43},"Yanan Wang, MD.PhD",{"facility":101,"status":48,"city":102,"state":84,"zip":103,"country":52,"countryCode":53,"cosmosGeoPoint":104,"geoPoint":108,"contacts":109},"The Affiliated Hospital of Guangdong Medical University","Zhanjiang","524001",{"type":55,"coordinates":105},[106,107],110.38749,21.23391,{"lat":107,"lon":106},[110],{"name":111,"role":41,"phone":112,"phoneExt":43,"email":113},"Qingwen Xu, MD","008613600387083","xuqwen@21cn.com",{"facility":115,"status":48,"city":116,"state":117,"zip":118,"country":52,"countryCode":53,"cosmosGeoPoint":119,"geoPoint":123,"contacts":124},"Affiliated Hospital of Zunyi Medical University","Zunyi","Guizhou","563003",{"type":55,"coordinates":120},[121,122],106.90722,27.68667,{"lat":122,"lon":121},[125],{"name":126,"role":41,"phone":127,"phoneExt":43,"email":128},"Ming Xie, MD","008615519202000","2581303091@qq.com",{"facility":130,"status":48,"city":131,"state":132,"zip":133,"country":52,"countryCode":53,"cosmosGeoPoint":134,"geoPoint":138,"contacts":139},"The Third Xiangya Hospital of Central South University","Changsha","Hunan","410013",{"type":55,"coordinates":135},[136,137],112.97087,28.19874,{"lat":137,"lon":136},[140],{"name":141,"role":41,"phone":43,"phoneExt":43,"email":43},"Yi Zhang, MD,PhD",{"facility":143,"status":48,"city":144,"state":132,"zip":145,"country":52,"countryCode":53,"cosmosGeoPoint":146,"geoPoint":150,"contacts":151},"The First Affiliated Hospital of University of South China","Hengyang","421001",{"type":55,"coordinates":147},[148,149],112.61888,26.88946,{"lat":149,"lon":148},[152],{"name":153,"role":41,"phone":154,"phoneExt":43,"email":155},"Jun Ouyang, MD","008613973426200","1847039906@qq.com",{"facility":157,"status":48,"city":158,"state":159,"zip":160,"country":52,"countryCode":53,"cosmosGeoPoint":161,"geoPoint":165,"contacts":166},"Department of Gastrointestinal Surgery, The First Hospital of Jilin University","Changchun","Jilin","130021",{"type":55,"coordinates":162},[163,164],125.32278,43.88,{"lat":164,"lon":163},[167],{"name":168,"role":41,"phone":169,"phoneExt":43,"email":170},"Quan Wang, MD,PhD","008615843073207","wangquanjdyy@163.com",{"facility":172,"status":48,"city":173,"state":174,"zip":175,"country":52,"countryCode":53,"cosmosGeoPoint":176,"geoPoint":180,"contacts":181},"Department of Colorectal Surgery, Shengjing Hospital of China Medical University","Shenyang","Liaoning","110004",{"type":55,"coordinates":177},[178,179],123.43278,41.79222,{"lat":179,"lon":178},[182],{"name":183,"role":41,"phone":184,"phoneExt":43,"email":185},"Hong Zhang, MD","008618940257919","haojiubujian1203@sina.cn",{"facility":187,"status":48,"city":188,"state":189,"zip":190,"country":52,"countryCode":53,"cosmosGeoPoint":191,"geoPoint":195,"contacts":196},"The First Affiliated Hospital of Xi'an Jiaotong University","Xi'an","Shaanxi","710061",{"type":55,"coordinates":192},[193,194],108.92861,34.25833,{"lat":194,"lon":193},[197],{"name":198,"role":41,"phone":199,"phoneExt":43,"email":200},"Yongchun Song, MD","008618991232549","dr.songyongchun@qq.com",{"facility":202,"status":48,"city":203,"state":204,"zip":205,"country":52,"countryCode":53,"cosmosGeoPoint":206,"geoPoint":210,"contacts":211},"Ruijin Hospital, Shanghai Jiao Tong University School of Medicine","Shanghai","Shanghai Municipality","200025",{"type":55,"coordinates":207},[208,209],121.45806,31.22222,{"lat":209,"lon":208},[212],{"name":213,"role":41,"phone":214,"phoneExt":43,"email":215},"Bo Feng, MD,PhD","008613512103996","fengbo2022@163.com",{"facility":217,"status":48,"city":203,"state":204,"zip":218,"country":52,"countryCode":53,"cosmosGeoPoint":219,"geoPoint":221,"contacts":222},"Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University,","200127",{"type":55,"coordinates":220},[208,209],{"lat":209,"lon":208},[223],{"name":224,"role":41,"phone":225,"phoneExt":43,"email":226},"Qing Xu, MD, PhD","008613761002053","renjixuqing@163.com",{"facility":228,"status":48,"city":229,"state":230,"zip":231,"country":52,"countryCode":53,"cosmosGeoPoint":232,"geoPoint":236,"contacts":237},"Department of Gastrointestinal Surgery，The Affiliated Nanchong Central Hospital of North Sichuan Medical College","Nanchong","Sichuan","637000",{"type":55,"coordinates":233},[234,235],106.08473,30.79508,{"lat":235,"lon":234},[238],{"name":239,"role":41,"phone":240,"phoneExt":43,"email":241},"Mingyang Ren, MD","008613890756","2861746489@qq.com",{"facility":243,"status":48,"city":244,"state":230,"zip":245,"country":52,"countryCode":53,"cosmosGeoPoint":246,"geoPoint":250,"contacts":251},"Department of gastrointestinal surgery, the Second People's Hospital of Yibin","Yibin","644000",{"type":55,"coordinates":247},[248,249],104.63994,28.7593,{"lat":249,"lon":248},[252],{"name":253,"role":41,"phone":254,"phoneExt":43,"email":255},"Miao Wu, MD","008613990905852","13990905852@163.com",{"facility":257,"status":48,"city":67,"state":43,"zip":258,"country":52,"countryCode":53,"cosmosGeoPoint":259,"geoPoint":261,"contacts":262},"XinQiao Hospital of Army Medical University","400037",{"type":55,"coordinates":260},[72,73],{"lat":73,"lon":72},[263],{"name":264,"role":41,"phone":265,"phoneExt":43,"email":266},"Dan Ma, MD,Phd","008615823555665","1054727918@qq.com",{"type":37,"investigatorFullName":268,"investigatorTitle":269,"investigatorAffiliation":5,"oldNameTitle":43,"oldOrganization":43},"Yanhong Deng","MD",[271,273,275,277,279,281,283,286,288,289,292,294,296,298,300],{"name":272,"class":6},"Peking Union Medical College Hospital",{"name":274,"class":6},"The First Hospital of Jilin University",{"name":276,"class":6},"RenJi Hospital",{"name":278,"class":6},"Shengjing Hospital",{"name":280,"class":6},"The Second People's Hospital of Yibin",{"name":282,"class":6},"Daping Hospital and the Research Institute of Surgery of the Third Military Medical University",{"name":284,"class":285},"Nanchong Central Hospital","OTHER_GOV",{"name":287,"class":6},"Zunyi Medical College",{"name":143,"class":6},{"name":290,"class":291},"Xinqiao Hospital","UNKNOWN",{"name":293,"class":6},"Nanfang Hospital, Southern Medical University",{"name":295,"class":6},"First Affiliated Hospital Xi'an Jiaotong University",{"name":297,"class":6},"Ruijin Hospital",{"name":299,"class":6},"Affiliated Hospital of Guangdong Medical University",{"name":130,"class":6},"100283201","transanal-versus-laparoscopic-total-mesorectal-excision-for-rectal-cancer-100283201",false,"NCT02966483","Transanal Versus Laparoscopic Total Mesorectal Excision for Rectal Cancer","Transanal Versus Laparoscopic Total Mesorectal Excision for Mid and Low Rectal Cancer (TaLaR): a Multicentre Randomised Clinical Trial","Inclusion Criteria:\n\nhistologically proven rectal adenocarcinoma;\n\ntumor located below the level of peritoneal reflection ;\n\ndiagnosis of rectal cancer amenable to curative surgery;\n\nno evidence of distant metastases;\n\npreoperative tumor stage within III;\n\nno threaten mesorectal fascia (MRF)after neoadjuvant therapy;\n\nno contraindication to laparoscopic surgery;\n\nwithout history of other malignancies;\n\nWritten informed consent\n\nExclusion Criteria:\n\ncould not perform sphincter preservation surgery (requiring a Mile's procedure);\n\nT4b tumor invading adjacent organs;\n\nT1 tumors that can be locally resected\n\nshould take neoadjuvant therapy but refuse it;\n\nrecurrent cancer;\n\nconcurrent or previous diagnosis of invasive cancer within 5 years;\n\nemergent surgery with intestinal obstruction or perforation;\n\nhistory of colorectal surgery;\n\nfecal incontinence;\n\nhistory of inflammatory bowel disease;\n\nwith contraindications to general anaesthesia(ASA class 4 or 5);\n\npregnant or breast-feeding;\n\nhistory of mental disorder","ALL","18 Years","75 Years",{"count":312,"type":313},1114,"ESTIMATED","INTERVENTIONAL",[316],"NA","Laparoscopic surgery for rectal cancer has been successfully proven to be a non-inferior alternative regarding resection quality, and oncological outcomes of patients as compared to open surgery in mangy clinical trails. Moreover, laparoscopic surgery is advantageous over open surgery with regard to operative invasiveness, patient's recovery, and wound related complications. Thus, laparoscopic surgery has gained great popularity over the past decades. However, specifically for mid and low rectal cancer, laparoscopic surgery is technically demanding, which sometimes leads to high morbidity and unsatisfactory resection quality, especially in challenging cases such as bulky mesorectum, enlarged prostate, irradiated pelvis, etc. Under this circumstance, transanal total mesorectal excision (TaTME) , the so called \"down-to-up\" alternative, has emerged as a promising solution to these problems in recent years and more and more small studies have proven the feasibility and advantages of this technique, making it become a hot topic among both literature and conferences. However, TaTME is still at early birth, higher-level evidences, either multicentric, or comparative study with conventional surgery is strikingly lacking. Thus the investigators conduct this multicentre randomised clinical trial, comparing transanal TME versus laparoscopic TME for mid and low rectal cancer, aiming to prove the hypothesis that TaTME may achieve better resection quality and result in non-inferior oncological outcome, as well as short term operative morbidity and mortality.",[319,320],"Rectal Neoplasms Malignant","Surgery",[322,323,324,325,326],"Rectal cancer","Laparoscopic surgery","Total mesorectal excision","Transanal","Multicentre randomised clinical trial","2025-01-15",{"date":329,"type":330},"2025-01-17","ACTUAL",{"date":332,"type":330},"2016-04",{"date":334,"type":313},"2026-07",{"name":5,"class":6},16]