[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100617690":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":34,"centralContacts":51,"locations":30,"responsibleParty":57,"collaborators":30,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":61,"sex":67,"minAge":68,"maxAge":30,"enrollmentInfo":69,"targetDuration":30,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":78,"overallStatus":88,"whyStopped":30,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":30},{"fullName":5,"class":6},"Medtronic Cardiovascular","INDUSTRY",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Medtronic Intrepid™ TTVR","EXPERIMENTAL","Transcatheter tricuspid valve replacement with Medtronic Intrepid™ TTVR System in patients with severe or greater tricuspid regurgitation.",[13],"Device: Medtronic Intrepid™ Transcatheter Tricuspid Valve Replacement (TTVR) System",{"label":15,"type":16,"description":17,"interventionNames":18},"Edwards EVOQUE TTVR","ACTIVE_COMPARATOR","Transcatheter tricuspid valve replacement with Edwards EVOQUE TTVR in patients with severe or greater tricuspid regurgitation.",[19],"Device: Edwards EVOQUE Tricuspid Valve Replacement (TTVR) System",{"label":21,"type":10,"description":22,"interventionNames":23},"Single Arm Registry","Transcatheter tricuspid valve replacement with Medtronic Intrepid™ TTVR System in patients with severe or greater tricuspid regurgitation who are not eligible for randomization.",[13],[25,31],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DEVICE","Medtronic Intrepid™ Transcatheter Tricuspid Valve Replacement (TTVR) System","Transcatheter Tricuspid Valve Replacement",[9,21],null,{"type":26,"name":32,"description":28,"armGroupLabels":33,"otherNames":30},"Edwards EVOQUE Tricuspid Valve Replacement (TTVR) System",[15],[35,39,42,45,48],{"name":36,"affiliation":37,"role":38},"Vinayak N. Bapat, MD","Minneapolis Heart Institute","PRINCIPAL_INVESTIGATOR",{"name":40,"affiliation":41,"role":38},"Anita Asgar, MD","Northwestern Medicine Bluhm Cardiovascular Institute",{"name":43,"affiliation":44,"role":38},"Nicolas Dumonteil, MD","Clinique Pasteur Groupe CardioVasculaire Interventionnel",{"name":46,"affiliation":47,"role":38},"Azeem Latib, MD","Montefiore Medical Center",{"name":49,"affiliation":50,"role":38},"Firas Zahr, MD","Knight Cardiovascular Institute",[52],{"name":53,"role":54,"phone":55,"phoneExt":30,"email":56},"Amber St Martin","CONTACT","612-380-5637","rs.pathfinder@medtronic.com",{"type":58,"investigatorFullName":30,"investigatorTitle":30,"investigatorAffiliation":30,"oldNameTitle":30,"oldOrganization":30},"SPONSOR","100617690","transcatheter-tricuspid-valve-replacement-with-the-medtronic-intrepid-transcatheter-tricuspid-valve-replacement-ttvr-system-in-severe-tricuspid-regurgitation-100617690",false,"NCT07321899","Transcatheter Tricuspid Valve Replacement With the Medtronic Intrepid™ Transcatheter Tricuspid Valve Replacement (TTVR) System in Severe Tricuspid Regurgitation","Transcatheter Tricuspid Valve Replacement Using the Medtronic Intrepid™ TTVR System in Patients With Severe Symptomatic Tricuspid Regurgitation - PATHFINDER","PATHFINDER","Inclusion Criteria:\n\n* Age ≥18 years at the time of consent.\n* Severe symptomatic tricuspid regurgitation (TR) despite optimal medical therapy (OMT).\n* Local site multidisciplinary heart team experienced in tricuspid valve therapies agrees that the subject is appropriate for TTVR.\n\nExclusion Criteria:\n\n* Any tricuspid device currently in place.\n* Anatomic contraindications.\n* Need for emergent or urgent surgery.\n* Left ventricular ejection fraction \\\u003C25%.","ALL","18 Years",{"count":70,"type":71},1186,"ESTIMATED","INTERVENTIONAL",[74],"NA","This clinical trial evaluates the safety and effectiveness of the Medtronic Intrepid™ Transcatheter Tricuspid Valve Replacement (TTVR) System in symptomatic patients with severe or greater tricuspid regurgitation.",[77],"Severe Tricuspid Regurgitation",[79,80,81,82,83,84,85,86,87],"Tricuspid Regurgitation","Symptomatic tricuspid regurgitation","Heart valve disease","Structural heart intervention","Severe valve disease","Randomized controlled trial","tricuspid insufficiency","tricuspid disease","tricuspid valve disease","NOT_YET_RECRUITING","2026-01-06",{"date":91,"type":92},"2026-01-08","ACTUAL",{"date":94,"type":71},"2026-06",{"date":96,"type":71},"2041-04",{"name":5,"class":6}]