[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637625":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":15,"locations":21,"responsibleParty":38,"collaborators":42,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":48,"sex":54,"minAge":55,"maxAge":10,"enrollmentInfo":56,"targetDuration":10,"studyType":59,"phases":10,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":24,"whyStopped":10,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":75},{"fullName":5,"class":6},"Cedars-Sinai Medical Center","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Surgical mitral repair",null,"This cohort includes patients who underwent surgical mitral valve repair for severe degenerative mitral regurgitation (DMR). The intervention involves standard surgical techniques to repair the mitral valve, aiming to restore its physiological function and reduce mitral regurgitation.",{"label":13,"type":10,"description":14,"interventionNames":10},"Transcatheter mitral edge-to-edge repair","This cohort includes patients who underwent transcatheter edge-to-edge repair (TEER) for severe degenerative mitral regurgitation (DMR). The intervention involves a minimally invasive transcatheter procedure using a device to approximate the mitral valve leaflets, reducing regurgitation.",[16],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},"Aakriti Gupta, M.D.","CONTACT","267-442-8776","aakriti.gupta@cshs.org",[22],{"facility":23,"status":24,"city":25,"state":26,"zip":27,"country":28,"countryCode":29,"cosmosGeoPoint":30,"geoPoint":35,"contacts":36},"Smidt Heart Institute, Cedars Sinai Medical Center","RECRUITING","Los Angeles","California","90048","United States","US",{"type":31,"coordinates":32},"Point",[33,34],-118.24368,34.05223,{"lat":34,"lon":33},[37],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},{"type":39,"investigatorFullName":40,"investigatorTitle":41,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Aakriti Gupta","Assistant Professor, Cardiology",[43],{"name":44,"class":45},"National Heart, Lung, and Blood Institute (NHLBI)","NIH","100637625","transcatheter-vs-surgical-treatment-of-degenerative-mitral-regurgitation-100637625",false,"NCT07605715","Transcatheter vs. Surgical Treatment of Degenerative Mitral Regurgitation","Transcatheter vs. Surgical Treatment of Degenerative Mitral Regurgitation: A Comparative Study of Clinical Outcomes, Patient Experiences, and Mechanistic Insights With Multimodality Imaging","DMR","Inclusion Criteria:\n\n* Patients older than 60 years who have DMR will be included in the study\n\nExclusion Criteria:\n\n* Patients with prior history of mitral intervention or surgery will be excluded.\n* Patient records flagged \"break the glass\" or \"research opt out\" will be excluded.\n* Persons with allergy to animal dander or animal-instigated asthma will be excluded.","ALL","60 Years",{"count":57,"type":58},60,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to compare the outcomes of transcatheter edge-to-edge repair (TEER) versus surgical mitral valve repair for degenerative mitral regurgitation (DMR) over the long term. The study aims to:\n\n1. Evaluate the effectiveness and safety of TEER versus surgery in patients with DMR over long term.\n2. Investigate the predictors of left ventricular dysfunction and clinical outcomes using advanced imaging techniques, such as cardiac MRI\n3. Assess patient-reported recovery and quality of life outcomes using validated tools.\n\nThe study focuses on improving care strategies for patients with DMR, particularly those at higher surgical risk, by identifying optimal treatment approaches and predictors of recovery.",[62],"Degenerative Mitral Valve Disease",[64,65,9],"TEER","Transcatheter mitral repair","2026-05-18",{"date":68,"type":69},"2026-05-26","ACTUAL",{"date":71,"type":69},"2025-02-19",{"date":73,"type":58},"2027-08",{"name":5,"class":6},1]