[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100645303":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":29,"locations":36,"responsibleParty":52,"collaborators":56,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":68,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":25,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":84,"overallStatus":95,"whyStopped":25,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":105},{"fullName":5,"class":6},"Center for Innovative Public Health Research","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"#TranscendentHealth","EXPERIMENTAL","Participants receive a gender-tailored text messaging sexual health program over 5 months. Program content addresses condom use, birth control options, HIV\u002FSTI testing, PrEP, gender-affirming care, sexual relationships, gender dysphoria, and social stressors relevant to AFAB transgender youth. The program includes a Text Buddy feature for peer-to-peer support with a matched participant, and interactive achievement Badges.",[13],"Behavioral: #TranscendentHealth",{"label":15,"type":16,"description":17,"interventionNames":18},"Universal Sexual Health Program","ACTIVE_COMPARATOR","Participants receive a universal (non-gender-tailored) sexual health text messaging program over the same 5-month period. The program delivers a comparable number of messages covering general adolescent sexual health education that is not tailored by gender identity. This arm does not include the Text Buddy peer-support feature.",[19],"Behavioral: Universal Sexual Health Program",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","A 5-month text messaging sexual health program for AFAB transgender and gender-diverse youth ages 14-18, adapted from the Girl2Girl program. Content is gender-inclusive and addresses sexual health protective behaviors, gender-affirming care, relationships, and social stressors specific to AFAB trans youth. Delivered entirely via text message; no in-person contact is required.",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"5-month general (non-gender-tailored) text messaging sexual health program covering contraception, STI testing, and healthy relationships - same duration and message volume as Arm 1, no Text Buddy feature",[15],[30],{"name":31,"role":32,"phone":33,"phoneExt":34,"email":35},"Michele Ybarra, PhD","CONTACT","877-302-6858","801","michele@innovativepublichealth.org",[37],{"facility":38,"status":25,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Center for Innovative Public Health Research (CiPHR)","San Clemente","California","92672","United States","US",{"type":45,"coordinates":46},"Point",[47,48],-117.61199,33.42697,{"lat":48,"lon":47},[51],{"name":31,"role":32,"phone":33,"phoneExt":34,"email":35},{"type":53,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Michele Ybarra","Principal Investigator",[57],{"name":58,"class":59},"National Institute of Nursing Research (NINR)","NIH","100645303","transcendenthealth-a-text-messaging-pregnancy-prevention-program-for-transgender-boys-100645303",false,"NCT07681908","#TranscendentHealth: A Text Messaging Pregnancy Prevention Program for Transgender Boys","#TranscendentHealth - Adapting an LGB+ Inclusive Teen Pregnancy Prevention Program for Transgender Boys","THPP","Inclusion Criteria:\n\n* Assigned female sex at birth\n* Does not have an exclusively cisgender gender identity (e.g., identifies as transgender boy, nonbinary, gender fluid, or unsure of gender identity)\n* Age 14 to 18 years and has not yet graduated from high school\n* Exclusive owner of a cell phone with an unlimited text messaging plan\n* Has access to the Internet to complete online surveys\n* Plans to keep the same cell phone number for at least the next 6 months\n* Able to provide informed assent (ages 14-17) or consent (age 18), including the capacity to do so\n* Has not participated in a prior #TranscendentHealth study activity and does not know anyone currently enrolled in the study\n\nExclusion Criteria:\n\n* Has graduated from high school\n* Has participated in a prior #TranscendentHealth study activity (focus groups, Content Advisory Teams, or beta test)\n* Knows another person currently enrolled in the study",true,"FEMALE","14 Years","18 Years",{"count":73,"type":74},467,"ESTIMATED","INTERVENTIONAL",[77],"NA","Transgender and gender-diverse young people who were assigned female at birth (AFAB), including transgender boys, nonbinary youth, and others, face real sexual health disparities. Existing pregnancy and HIV prevention programs are designed for cisgender girls and do not meet the needs of AFAB trans youth, leaving this group without programs that speak to their lives.\n\n#TranscendentHealth is a text messaging sexual health program developed specifically for AFAB transgender and gender-diverse youth ages 14 to 18. It builds on Girl2Girl, a program shown to improve sexual health behaviors in LGB+ cisgender girls, and updates the content to reflect the identities, relationships, and health needs of AFAB trans youth.\n\nThe study has two parts. In the first part, AFAB trans youth help shape the program through focus groups, Content Advisory Teams (youth review panels that give feedback on program messages), and a small pilot test. In the second part, a national randomized controlled trial enrolls 467 AFAB transgender youth ages 14 to 18 across the United States. Participants are randomly assigned to receive either #TranscendentHealth or a general sexual health text messaging program. Both programs are delivered entirely by text message over 5 months, with no in-person visits required. Youth complete short online surveys at the start of the program, at program end (5 months), and at 3 and 6 months after the program ends.\n\nThe study's main goals are to determine whether #TranscendentHealth improves rates of condom-protected sex, use of other birth control methods (such as the pill, shot, or IUD), and HIV\u002FSTI testing. Secondary goals include reducing unintended pregnancy, increasing PrEP uptake among eligible participants, and improving intentions to use sexual health services.",[80,81,82,83],"Pregnancy (Unwanted)","Sexually Transmitted Disease (STD)","HIV Infection","Sexual Behavior",[85,86,87,88,89,90,91,92,93,94],"transgender youth","Nonbinary youth","Assigned female at birth (AFAB)","Pregnancy prevention","Text messaging","mHealth","Sexual health","Gender minority youth","HIV prevention","Contraception","NOT_YET_RECRUITING","2026-07-01",{"date":98,"type":99},"2026-07-02","ACTUAL",{"date":101,"type":74},"2026-06-30",{"date":103,"type":74},"2028-06-30",{"name":5,"class":6},1]