[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100588531":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":11,"centralContacts":23,"locations":29,"responsibleParty":44,"collaborators":11,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":11,"eligibilityCriteria":52,"healthyVolunteers":48,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":11,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":11,"overallStatus":32,"whyStopped":11,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":74},{"fullName":5,"class":6},"Xuanwu Hospital, Beijing","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Neurostimulation group","EXPERIMENTAL",null,[13],"Device: transcranial electrical stimulation treatment.",{"label":15,"type":16,"description":11,"interventionNames":11},"Sham neurostimulation group","NO_INTERVENTION",[18],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":11},"DEVICE","transcranial electrical stimulation treatment.","Stimulation targeting the primary motor cortex, current intensity is 1-2mA, duration is 30 minutes, once daily for 5 consecutive days",[9],[24],{"name":25,"role":26,"phone":27,"phoneExt":11,"email":28},"Junwei Hao, MD","CONTACT","01083198277","haojunwei@vip.163.com",[30],{"facility":31,"status":32,"city":33,"state":11,"zip":11,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"Xuanwu Hospital, Capital Medical University","RECRUITING","Beijing","China","CN",{"type":37,"coordinates":38},"Point",[39,40],116.39723,39.9075,{"lat":40,"lon":39},[43],{"name":25,"role":26,"phone":27,"phoneExt":11,"email":28},{"type":45,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100588531","transcranial-electrical-stimulation-for-treating-chronic-pain-in-inflammatory-demyelinating-diseases-100588531",false,"NCT06942611","Transcranial Electrical Stimulation for Treating Chronic Pain in Inflammatory Demyelinating Diseases","A Study on the Therapeutic Effects of Transcranial Electrical Stimulation Combined on Chronic Pain in Central Nervous System Inflammatory Demyelinating Diseases","Inclusion Criteria:\n\nPatients diagnosed with neuromyelitis optica spectrum disorder, multiple sclerosis, or other central nervous system inflammatory demyelinating diseases that meet the diagnostic criteria;\n\nNumeric Rating Scale (NRS) pain score ≥4;\n\nAge between 18 and 65 years, regardless of gender;\n\nStable dose of immunosuppressive therapy for at least one month;\n\nEDSS score ≤6;\n\nRight-handed;\n\nAgree to participate and sign the informed consent form.\n\nExclusion Criteria:\n\nA history of relapse within the past month;\n\nRecent medication adjustments or treatment with modified electroconvulsive therapy, transcranial magnetic stimulation, or other neurostimulation techniques within the past month;\n\nParticipation in any other clinical trial within the past month or currently participating in another clinical trial;\n\nPresence of cochlear implants, pacemakers, or implanted stimulators in the brain;\n\nSkin integrity at the electrode placement site is compromised, or allergy to electrode gel or adhesive;\n\nA history of epilepsy, hydrocephalus, central nervous system tumors, brain injury, or intracranial infections;\n\nPregnant or breastfeeding women, or those planning to become pregnant in the near future;\n\nA score of ≥3 on item 3 (suicide item) of the HDRS-17, or a history of severe psychiatric disorders;\n\nPresence of severe or unstable organic diseases;\n\nPoor patient compliance preventing cooperation with treatment, follow-up, or clinical, EEG, and imaging data collection;\n\nAny other situation deemed unsuitable for participation in the study by the investigator.","ALL","18 Years","65 Years",{"count":57,"type":58},80,"ESTIMATED","INTERVENTIONAL",[61],"NA","Non-invasive neurostimulation can effectively improve patients' symptoms and has shown good therapeutic efficacy in alleviating the symptoms of IIDDs (Inflammatory Immune-mediated Demyelinating Diseases). However, some patients have not achieved the desired results, which may be due to individual differences in neural responsiveness . Therefore, this study aims to assess the therapeutic effect of transcranial electrical stimulation on improving symptoms such as painful spasm in IIDDs patients, by considering both the overall characteristics of IIDDs disease symptoms and individual differences in patients. The study will explore the imaging characteristics, electrophysiological features of the disease symptoms, and their relationship with clinical manifestations, while analyzing the key factors that influence treatment efficacy.",[64],"Idiopathic Inflammatory Demyelinating Disorders of the Central Nervous System","2025-06-26",{"date":67,"type":68},"2025-07-01","ACTUAL",{"date":70,"type":68},"2025-05-03",{"date":72,"type":58},"2027-07-31",{"name":5,"class":6},1]