[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100575305":3},{"organization":4,"armGroups":7,"interventions":28,"overallOfficials":47,"centralContacts":51,"locations":60,"responsibleParty":76,"collaborators":34,"id":78,"slug":79,"hasResults":80,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":86,"sex":87,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":34,"studyType":93,"phases":94,"briefSummary":96,"conditions":97,"keywords":101,"overallStatus":62,"whyStopped":34,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":113},{"fullName":5,"class":6},"Wake Forest University Health Sciences","OTHER",[8,16,20,24],{"label":9,"type":6,"description":10,"interventionNames":11},"Four Day - Option 1","Participants will receive active iTBS, sham iTBS, 10 Hz, 1 Hz.",[12,13,14,15],"Device: Sham iTBS","Device: Active iTBS","Device: 10 Hz TMS","Device: 1 Hz TMS",{"label":17,"type":6,"description":18,"interventionNames":19},"Two Day - Option 1","Participants will receive active iTBS then sham iTBS.",[12,13],{"label":21,"type":6,"description":22,"interventionNames":23},"Four Day - Option 2","Participants will receive sham iTBS, active iTBS, 1 Hz, 10 Hz.",[12,13,14,15],{"label":25,"type":6,"description":26,"interventionNames":27},"Two Day - Option 2","Participants will receive sham iTBS then active iTBS.",[12,13],[29,35,39,43],{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"DEVICE","Sham iTBS","Participants will receive sham iTBS",[9,21,17,25],null,{"type":30,"name":36,"description":37,"armGroupLabels":38,"otherNames":34},"Active iTBS","Participants will receive active iTBS",[9,21,17,25],{"type":30,"name":40,"description":41,"armGroupLabels":42,"otherNames":34},"10 Hz TMS","Participant will receive 10 Hz TMS",[9,21],{"type":30,"name":44,"description":45,"armGroupLabels":46,"otherNames":34},"1 Hz TMS","Participant will receive 1 Hz TMS",[9,21],[48],{"name":49,"affiliation":5,"role":50},"Merideth A Addicott, PhD","PRINCIPAL_INVESTIGATOR",[52,56],{"name":49,"role":53,"phone":54,"phoneExt":34,"email":55},"CONTACT","336-716-7792","Maddicot@wakehealth.edu",{"name":57,"role":53,"phone":58,"phoneExt":34,"email":59},"Michiyah Kimber","3367165719","michcoll@wakehealth.edu",[61],{"facility":5,"status":62,"city":63,"state":64,"zip":65,"country":66,"countryCode":67,"cosmosGeoPoint":68,"geoPoint":73,"contacts":74},"RECRUITING","Winston-Salem","North Carolina","27157","United States","US",{"type":69,"coordinates":70},"Point",[71,72],-80.24422,36.09986,{"lat":72,"lon":71},[75],{"name":49,"role":53,"phone":54,"phoneExt":34,"email":55},{"type":77,"investigatorFullName":34,"investigatorTitle":34,"investigatorAffiliation":34,"oldNameTitle":34,"oldOrganization":34},"SPONSOR","100575305","transcranial-magnetic-stimulation-tms-effects-using-magnetoencephalography-meg-study-100575305",false,"NCT06770556","Transcranial Magnetic Stimulation (TMS) Effects Using Magnetoencephalography (MEG) Study","An Investigation of TMS Effects Using Magnetoencephalography (MEG) Among Individuals With and Without Heavy Alcohol Use","TMS","Inclusion Criteria non-AUD Participants:\n\n* Diagnostic and Statistical Manual of Mental Disorders (DSM-5) score for AUD = 0\n* Alcohol Use Disorders Identification Test (AUDIT) score ≤ 7\n* Is not a heavy alcohol consumer\n\nInclusion Criteria AUD Participants:\n\n* DSM-5 score for AUD ≥ 3\n* AUDIT score ≥ 8\n* Is a heavy alcohol consumer\n\nExclusion Criteria:\n\n* Current substance use disorder other than alcohol use disorder and\u002For frequent use of non-prescribed psychoactive substances.\n* Current serious psychiatric disorder, and\u002For any history of a psychotic disorder\n* Any health problem that would interfere with the study or could be aggravated by study procedures (e.g., history of migraines, claustrophobia).\n* Is currently taking or initiates a medication known to affect alcohol intake and\u002For craving.\n* History of traumatic brain injury resulting in hospitalization, loss of consciousness, and\u002For having ever been informed he\u002Fshe has an epidural, subdural, or subarachnoid hemorrhage.\n* Does not meet safety criteria for TMS or MRI.\n* Females of childbearing potential who are pregnant (by urine HCG), planning to become pregnant, nursing, or who are not using a reliable form of birth control.\n* Is at an elevated risk of seizure (i.e. has a history of seizures, is currently prescribed medications known to lower seizure threshold and has had a change in their medication).\n* Clinical Intake Withdrawal Assessment (CIWA\\>5) (to prevent delivering TMS to individuals in withdrawal).\n* Not able to read and understand questionnaires, assessments, and\u002For the informed consent.",true,"ALL","21 Years","65 Years",{"count":91,"type":92},10,"ESTIMATED","INTERVENTIONAL",[95],"NA","Alcohol use disorder (AUD) is a complex chronic brain disease characterized by compulsive alcohol use, loss of control over drinking, and negative emotional states. Extensive research has identified the general neural circuitry underlying AUD. There is an exciting opportunity to intervene in AUD using neuromodulation. Transcranial magnetic stimulation (TMS) offers a non-invasive method to modulate brain activity, making it a promising tool for investigating, modulating, and potentially treating AUD. However, the precise effects of TMS on neural circuits involved in AUD and the mechanisms underlying these effects must first be understood. Magnetoencephalography (MEG) is a neuroimaging method that provides direct measurement of brain activity within neural circuits with high temporal resolution. Critically, MEG can measure brain activity in a wide range of frequencies that are consistent with those targeted by TMS. The goal of this proposal is therefore to collect preliminary and feasibility data to support a future NIH grant application that would use MEG to investigate TMS effects in individuals with AUD (iAUD).",[98,99,100],"Alcohol Use Disorder","Alcohol Dependence","Alcohol Consumption",[102,103,98],"Transcranial Magnetic Stimulation (TMS)","Magnetoencephalography (MEG)","2026-04-15",{"date":106,"type":107},"2026-04-17","ACTUAL",{"date":109,"type":107},"2025-03-21",{"date":111,"type":92},"2026-12-31",{"name":5,"class":6},1]