[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100603236":3},{"organization":4,"armGroups":7,"interventions":28,"overallOfficials":34,"centralContacts":40,"locations":46,"responsibleParty":66,"collaborators":34,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":34,"eligibilityCriteria":76,"healthyVolunteers":77,"sex":78,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":34,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":49,"whyStopped":34,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"University of Texas at Austin","OTHER",[8,15,20,24],{"label":9,"type":10,"description":11,"interventionNames":12},"Arm 1: attention bias assessment (ABA), transcranial photobiomodulation (tPBM)","ACTIVE_COMPARATOR","Participants will receive attention bias assessment (ABA) in conjunction with active transcranial photobiomodulation (tPBM) treatment to the forehead.",[13,14],"Behavioral: Attention bias assessment and modification","Device: Transcranial photobiomodulation",{"label":16,"type":17,"description":18,"interventionNames":19},"Arm 2: attention bias assessment (ABA), sham tPBM","SHAM_COMPARATOR","Participants will receive attention bias assessment (ABA) in conjunction with sham (laser light off) transcranial photobiomodulation (tPBM) treatment to the forehead.",[13],{"label":21,"type":10,"description":22,"interventionNames":23},"Arm 3: attention bias assessment and modification (ABA\u002FABM), transcranial photobiomodulation (tPBM)","Participants will receive attention bias assessment plus attention bias modification (ABA\u002FABM) in conjunction with active transcranial photobiomodulation (tPBM) treatment to the forehead.",[13,14],{"label":25,"type":17,"description":26,"interventionNames":27},"Arm 4: attention bias assessment and modification (ABA\u002FABM), sham tPBM","Participants will receive attention bias assessment plus attention bias modification (ABA\u002FABM) in conjunction with sham (laser light off) transcranial photobiomodulation (tPBM) treatment to the forehead.",[13],[29,35],{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"BEHAVIORAL","Attention bias assessment and modification","Attention bias assessment and modification involve two versions of the dot-probe task. These tasks are based on the premise that repeated attention shifts can retrain attentional biases, with the expectation that reducing attentional bias toward threats will alleviate sub-clinical anxiety symptoms.",[9,16,21,25],null,{"type":36,"name":37,"description":38,"armGroupLabels":39,"otherNames":34},"DEVICE","Transcranial photobiomodulation","Participants will receive near-infrared light at 1064 nanometers to the right side of the forehead for 8 minutes. The investigators have introduced this form of transcranial photobiomodulation (tPBM) as a means of human cognitive enhancement, and as an adjunct for attention bias modification for the reduction of symptoms of depression. In the present study, the investigators wish to extend these findings to the use of attention bias modification for the reduction of sub-clinical anxiety.",[9,21],[41],{"name":42,"role":43,"phone":44,"phoneExt":34,"email":45},"Francisco Gonzalez-Lima, Ph.D.","CONTACT","512-537-5257","utanxietystudy1@gmail.com",[47],{"facility":48,"status":49,"city":50,"state":51,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"The University of Texas at Austin","RECRUITING","Austin","Texas","78712","United States","US",{"type":56,"coordinates":57},"Point",[58,59],-97.74306,30.26715,{"lat":59,"lon":58},[62,64],{"name":42,"role":43,"phone":44,"phoneExt":34,"email":63},"utbrainproject@gmail.com",{"name":42,"role":65,"phone":34,"phoneExt":34,"email":34},"PRINCIPAL_INVESTIGATOR",{"type":67,"investigatorFullName":68,"investigatorTitle":69,"investigatorAffiliation":5,"oldNameTitle":34,"oldOrganization":34},"SPONSOR_INVESTIGATOR","Francisco Gonzalez-Lima, PhD","Professor; Director, Texas Consortium in Behavioral Neuroscience","100603236","transcranial-photobiomodulation-in-anxiety-disorders-100603236",false,"NCT07133893","Transcranial Photobiomodulation in Anxiety Disorders","Effects of Transcranial Photobiomodulation and Attention Bias Modification on Anxiety Symptoms and Brain Hemodynamics","Inclusion Criteria:\n\n* 18 years of age and older\n* State-Trait Anxiety Index (STAI) questionnaire score between 40-59 (indicates moderate sub-clinical anxiety)\n* Patient Health Questionnaire (PHQ-9) score between 1-9 (indicates minimal to mild sub-clinical depression)\n\nExclusion Criteria:\n\n* STAI score less than 40 or greater than 59\n* PHQ-9 score greater than 9\n* Medication instability (i.e., medication change within 6 weeks)\n* Indicated suicidal ideation\n* Currently receiving tPBM treatment\n* Current pregnancy",true,"ALL","18 Years","100 Years",{"count":82,"type":83},280,"ESTIMATED","INTERVENTIONAL",[86],"NA","The investigators have previously shown that safe, non-invasive methods of brain stimulation such as the administration of transcranial infrared light can result in improvements to cognition and emotion. The investigators hypothesize that transcranial photobiomodulation (tPBM) can be used in conjunction with attention bias assessment and modification to reduce anxiety symptoms in individuals with sub-clinical anxiety.",[89],"Symptoms of Anxiety",[91,92,93,94],"Photobiomodulation","Sub-clinical anxiety","Near-infrared spectroscopy (NIRS)","attention bias modification","2026-05-11",{"date":97,"type":98},"2026-05-14","ACTUAL",{"date":100,"type":98},"2025-09-01",{"date":102,"type":83},"2028-09",{"name":68,"class":6},1]