[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100591173":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":30,"locations":26,"responsibleParty":36,"collaborators":26,"id":40,"slug":41,"hasResults":42,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":26,"eligibilityCriteria":46,"healthyVolunteers":42,"sex":47,"minAge":26,"maxAge":26,"enrollmentInfo":48,"targetDuration":26,"studyType":51,"phases":52,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":61,"whyStopped":26,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":26},{"fullName":5,"class":6},"Neuromed IRCCS","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"HD patients undergo real tSMS","ACTIVE_COMPARATOR","Each HD patients undergo tSMS (real) in two sessions per day, each lasting 60 minutes.",[13],"Device: Portable ergonomic helmet for real tSMS",{"label":15,"type":16,"description":17,"interventionNames":18},"HD patients undergo placebo tSMS","SHAM_COMPARATOR","Each HD patients undergo tSMS (placebo), in two sessions per day, each lasting 60 minutes.",[19],"Device: portable ergonomic helmet for placebo tSMS",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Portable ergonomic helmet for real tSMS","Unlike repetitive magnetic stimulation (rTMS), tSMS is attracting considerable interest because it is more manageable and easy to apply. It is a method applicable through a portable ergonomic helmet that shifts the paradigm of non-invasive brain stimulation (NIBS) from a center-based therapeutic model to a home-based one.",[9],null,{"type":22,"name":28,"description":24,"armGroupLabels":29,"otherNames":26},"portable ergonomic helmet for placebo tSMS",[15],[31],{"name":32,"role":33,"phone":34,"phoneExt":26,"email":35},"Diego Centonze, MD","CONTACT","+39 0865929703","trial.clinici1@gmail.com",{"type":37,"investigatorFullName":38,"investigatorTitle":39,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Diego Centonze","MD, Principal Investigator","100591173","transcranial-static-magnetic-stimulation-tsms-in-huntingtons-disease-hd-100591173",false,"NCT06976983","Transcranial Static Magnetic Stimulation (tSMS) in Huntington's Disease (HD)","Effects of Transcranial Static Magnetic Stimulation (tSMS) in the Treatment of Hyperkinetic Symptoms of Huntington's Disease","Inclusion Criteria:\n\n* Diagnosis of HD genetically confirmed (number of CAG triplets ≥36)\n* Presence of chorea movements quantified with a score ≥ 10 on the sum of the scores of the subscale of the Unified Huntington's Disease Rating Scale (UHDRS) for the evaluation of maximum chorea for the facial, oro-bucco-lingual, truncal, four limbs districts\n* Ability to provide written informed consent\n* No changes in drug therapy in the 8 weeks prior to the baseline visit\n* No changes in drug therapy for the entire duration of the study\n\nExclusion Criteria:\n\n* Contraindications to exposure to magnetic fields\n* Patients who are pregnant or breastfeeding\n* Presence of significant risk of suicidal behavior\n* Patients who have received an investigational drug in a clinical trial within 30 days of the baseline visit or have planned to use such an investigational drug during the study","ALL",{"count":49,"type":50},30,"ESTIMATED","INTERVENTIONAL",[53],"NA","Huntington's disease (HD) is a neurodegenerative pathology characterized by choreic hyperkinesias which represent the typical motor symptom and are represented by involuntary, aimless, irregular, recurrent, unpredictable and non-rhythmic movements of the trunk, face and limbs.\n\nNon-invasive brain neuromodulation has been proposed as a possible treatment for involuntary movements in several clinical conditions including HD.\n\nThe objective of the study is to evaluate the effect of home treatment with repeated sessions of transcranial static magnetic field stimulation (tSMS) in safely reducing choreic hyperkinesis in HD patients.",[56],"Huntington Disease",[58,59,60],"huntington disease","transcranial stimulation with static magnetic field","hyperckinesia","NOT_YET_RECRUITING","2025-05-10",{"date":64,"type":65},"2025-05-16","ACTUAL",{"date":67,"type":50},"2025-09-01",{"date":69,"type":50},"2026-04-30",{"name":5,"class":6}]