[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100629284":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":41,"responsibleParty":57,"collaborators":26,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":26,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":26,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":78,"overallStatus":80,"whyStopped":26,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Shanghai Mental Health Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"tTIS stimulation group","EXPERIMENTAL","The two high-frequency electric fields of the temporal interference (TI) device are set at distinct frequencies (2 kHz and 2.010 kHz), thereby generating a low-frequency electric field (10 Hz) specifically targeted at the amygdala.\n\nFor each participant, the current intensity was determined via electric field simulation to implement an individualized intervention protocol. The intervention lasted for one week, administered twice session daily for 30 minutes per session.",[13],"Device: tTIS on Amygdala, 10 Hz",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham tTIS stimulation group","SHAM_COMPARATOR","The two high-frequency electric fields of the temporal interference (TI) device are set at the same frequencies (2 kHz and 2 kHz), which are specifically targeted at the amygdala. For each participant, the current intensity was determined via electric field simulation to implement an individualized intervention protocol. The intervention lasted for one week, administered twice session daily for 30 minutes per session.",[19],"Device: tTIS on Amygdala, Sham",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","tTIS on Amygdala, 10 Hz","Through the transcranial electric stimulation device, the first pair of electrodes continuously outputs a current with a frequency of f1 = 2 kHz, while the second pair continuously outputs a current with a frequency of f2 = 2.010 kHz. According to the principle of time-domain coherence, an alternating electric field with a frequency of f2-f1 = 10 Hz can be generated in the target area. The optimal electrode position and current parameters are determined by using the individualized modeling. For each participant, the current intensity was determined via electric field simulation to implement an individualized intervention protocol.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"tTIS on Amygdala, Sham","The first pair of electrodes continuously outputs a current with a frequency of f1 = 2 kHz, while the second pair continuously outputs a current with a frequency of f2 = 2 kHz. The optimal electrode position and current parameters are determined by using the individualized modeling. For each participant, the current intensity was determined via electric field simulation to implement an individualized intervention protocol.",[15],[32],{"name":33,"affiliation":5,"role":34},"Min Zhao, M.D, Ph.D","PRINCIPAL_INVESTIGATOR",[36],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},"Tianzhen Chen, M.D, Ph.D","CONTACT","021-34773523","vomchan@hotmail.com",[42],{"facility":5,"status":26,"city":43,"state":26,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Shanghai","200000","China","CN",{"type":48,"coordinates":49},"Point",[50,51],121.45806,31.22222,{"lat":51,"lon":50},[54],{"name":33,"role":38,"phone":55,"phoneExt":26,"email":56},"18017311005","drminzhao@smhc.org.cn",{"type":58,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100629284","transcranial-temporal-interference-stimulation-targeted-of-the-amygdala-as-an-intervention-for-alcohol-use-disorder-patients-100629284",false,"NCT07472673","Transcranial Temporal Interference Stimulation Targeted of the Amygdala as an Intervention for Alcohol Use Disorder Patients","Exploring the Efficacy and Neural Mechanisms of Transcranial Temporal Interference Stimulation Modulating the Amygdala on Patients With Alcohol Use Disorder","Inclusion Criteria:\n\n* aged 18 to 60 years old;\n* Meets the DSM-5 diagnostic criteria for alcohol use disorder;\n* Normal or corrected normal vision and hearing;\n* Able to cooperate in completing the questionnaire assessment and behavioral tests;\n* No metal implantation in the head, no history of neurological problems or head injury.\n\nExclusion Criteria:\n\n* Suffering from severe cognitive dysfunction, such as a history of head trauma, cerebrovascular disease, epilepsy, etc., use of cognitive-promoting medications in the last 6 months;\n* serious physical or neurological illness, a diagnosis of any other psychiatric disorder under DSM-5 criteria (except for nicotine use disorder); Other psychoactive substance abuse or dependence in the last 5 years (except nicotine).\n* any contraindications to transcranial electrical stimulation.","MALE","18 Years","60 Years",{"count":70,"type":71},60,"ESTIMATED","INTERVENTIONAL",[74],"NA","The purpose of this research is to investigate the efficacy of transcranial temporal interference stimulation (tTIS) targeting the amygdala in patients with alcohol use disorder.",[77],"Alcohol Use Disorder",[79],"Alcohol use disorder","NOT_YET_RECRUITING","2026-03-12",{"date":83,"type":84},"2026-03-16","ACTUAL",{"date":86,"type":71},"2026-02-15",{"date":88,"type":71},"2026-12-31",{"name":5,"class":6},1]