[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633788":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":35,"locations":44,"responsibleParty":67,"collaborators":70,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":77,"sex":83,"minAge":84,"maxAge":25,"enrollmentInfo":85,"targetDuration":25,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":94,"overallStatus":97,"whyStopped":25,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"University Hospital, Geneva","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental arm: tTIS stimulation protocol","EXPERIMENTAL","In this arm, patients with essential tremor who are candidates for MRgHIFU will undergo the tTIS stimulation protocol before MRgHIFU. The tremor changes will be monitored using Inertial Measurement Units (IMUs) during the tTIS, as well as after tTIS and MRgHIFU.",[13,14],"Device: Transcranial temporal interference stimulation","Other: Tremor monitoring through Inertial Measurement Units (IMUs)",{"label":16,"type":6,"description":17,"interventionNames":18},"Control arm: Tremor Monitoring","In this arm, essential tremor patients who are candidates for MRgHIFU will undergo only tremor monitoring using Inertial Measurement Units (IMUs) before and after MRgHIFU.",[14],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Transcranial temporal interference stimulation","We will deliver transcranial temporal interference stimulation (tTIS) via the DS5 stimulator (Digitimer Ltd.) in patients with essential tremor who are candidates for MRgHIFU to examine its ability to modulate the tremor amplitude.",[9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Tremor monitoring through Inertial Measurement Units (IMUs)","Essential tremor patients candidates for MRgFUS, whether undergoing the tTIS protocol (experimental arm) or acting as controls (control arm), will undergo a tremor quantification through Inertial Measurement Units (IMUs) before, during, and after the stimulation (for the experimental arm), as well as before and after MRgHIFU (both arms).",[16,9],[31],{"name":32,"affiliation":33,"role":34},"Christian Lüscher, Full Professor","Department of Basic Neuroscience, University of Geneva","PRINCIPAL_INVESTIGATOR",[36,40],{"name":32,"role":37,"phone":38,"phoneExt":25,"email":39},"CONTACT","‭+41 22 379 54 44","christian.luscher@unige.ch",{"name":41,"role":37,"phone":42,"phoneExt":25,"email":43},"Vanessa Fleury, Privat Docent","+41 22 372 83 37","vanessa.fleurynissen@hug.ch",[45],{"facility":46,"status":25,"city":47,"state":25,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"University of Geneva (UNIGE)","Geneva","1205","Switzerland","CH",{"type":52,"coordinates":53},"Point",[54,55],6.14569,46.20222,{"lat":55,"lon":54},[58,60,61,62,65],{"name":32,"role":37,"phone":59,"phoneExt":25,"email":39},"+41 22 379 54 44",{"name":41,"role":37,"phone":42,"phoneExt":25,"email":43},{"name":41,"role":34,"phone":25,"phoneExt":25,"email":25},{"name":63,"role":64,"phone":25,"phoneExt":25,"email":25},"Shahan Momjian, Associate Professor","SUB_INVESTIGATOR",{"name":66,"role":64,"phone":25,"phoneExt":25,"email":25},"Alma Lingenberg, Medical Doctor",{"type":34,"investigatorFullName":68,"investigatorTitle":69,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Vanessa Fleury","Head of the Movement Disorders unit, Neurology Department",[71,73],{"name":72,"class":6},"University of Geneva, Switzerland",{"name":74,"class":6},"Wyss Center for Bio and Neuroengineering","100633788","transcranial-temporal-interference-stimulation-ttis-to-modulate-essential-tremor-100633788",false,"NCT07531238","Transcranial Temporal Interference Stimulation (tTIS) To Modulate Essential Tremor","Transcranial Temporal Interference Stimulation (tTIS) To Modulate Essential Tremor: A Single-Center, Proof-of-Concept Study (TremorTIS (Pilot))","TremorTIS","Inclusion Criteria (for both arms):\n\n* Informed Consent signed by the subject;\n* Age ≥ 18 years;\n* Diagnosis of Essential Tremor (ET) based on the proposed criteria by the Movement Disorders Society;\n* Candidate for MRgHIFU thalamotomy\n\nExclusion Criteria (for both arms):\n\n* Unable to provide informed consent;\n* Severe sensory or cognitive impairment or musculoskeletal dysfunction that prohibits understanding instructions or performing the experimental tasks.\n\nOnly for patients undergoing the tTIS protocol (experimental arm):\n\n* Severe neuropsychiatric (e.g., major depression, severe dementia, psychosis) or unstable systemic diseases (e.g., severe progressive and unstable cancer, life-threatening infectious disease);\n* Inability to follow or non-compliance with the procedures of the study;\n* Contraindications for non-invasive brain stimulation:\n\n  * Electronic or ferromagnetic medical implants or devices\n  * History of seizures","ALL","18 Years",{"count":86,"type":87},6,"ESTIMATED","INTERVENTIONAL",[90],"NA","The goal of this proof-of-concept study is to examine the effects of a relatively new, non-invasive electrical current-based technique, transcranial temporal interference stimulation (tTIS), in patients with Essential Tremor (ET). TTIS is delivered via a Digitimer Ltd. stimulator, the \"DS5 Isolated Bipolar Constant Current Stimulator.\" The method enables targeting deep cerebral structures to selectively modulate neurons. The structure of interest in the present study is the ventralis intermedius (VIM) of the thalamus, which plays a key role in tremor generation in people with essential tremor. Therefore, techniques targeting the VIM nucleus can potentially improve the tremor and the quality of life in the long term, as is the case with MRI-guided high-intensity focused ultrasound (MRgHIFU). Despite its efficiency, MRgHIFU can lead to side effects that could benefit from improved predictive modeling. In our proof-of-concept study, the investigators aim to examine whether tTIS of the VIM nucleus can alter tremor characteristics and, therefore, mimic the effects of MRgHIFU. This work would pave the way for future clinical trials to design prediction tools for MRgHIFU if the investigators can demonstrate the positive impact of tTIS.",[93],"Essential Tremor",[22,95,93,96],"Neuromodulation","Nucleus ventralis intermedius","NOT_YET_RECRUITING","2026-04-27",{"date":100,"type":101},"2026-05-01","ACTUAL",{"date":103,"type":87},"2026-05-26",{"date":105,"type":87},"2027-05",{"name":5,"class":6},1]