[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100608107":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":17,"locations":23,"responsibleParty":45,"collaborators":47,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":10,"eligibilityCriteria":56,"healthyVolunteers":52,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":10,"studyType":63,"phases":10,"briefSummary":64,"conditions":65,"keywords":70,"overallStatus":26,"whyStopped":10,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Mỹ Đức Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"PCOS Women Undergoing CAPA-IVM",null,"Women aged 18-38 years with PCOS (Rotterdam criteria) indicated for CAPA-IVM. From each participant, 15 cumulus-oocyte complexes (COCs) are allocated to single-culture CAPA-IVM. Cumulus cells from these COCs are collected at oocyte denudation for RNA sequencing and transcriptomic analysis.",[13],{"name":14,"affiliation":15,"role":16},"Lan N Vương, PhD, MD","University of Medicine and Pharmacy at Ho Chi Minh City","PRINCIPAL_INVESTIGATOR",[18],{"name":19,"role":20,"phone":21,"phoneExt":10,"email":22},"Huy H Pham, MSc.","CONTACT","+84966145510","huy.ph@myduchospital.vn",[24],{"facility":25,"status":26,"city":27,"state":10,"zip":10,"country":28,"countryCode":29,"cosmosGeoPoint":30,"geoPoint":35,"contacts":36},"My Duc Hospital","RECRUITING","Ho Chi Minh City","Vietnam","VN",{"type":31,"coordinates":32},"Point",[33,34],106.62965,10.82302,{"lat":34,"lon":33},[37,41],{"name":38,"role":20,"phone":39,"phoneExt":10,"email":40},"Tuong M Ho, MD","+84903633377","tuongho.ivfmd@gmail.com",{"name":42,"role":20,"phone":43,"phoneExt":10,"email":44},"Lan N Vuong, MD, PhD","+84903008889","drlan@yahoo.com.vn",{"type":46,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[48],{"name":49,"class":6},"Vrije Universiteit Brussel","100608107","transcriptomic-profiling-of-cumulus-cells-from-capa-ivm-100608107",false,"NCT07197255","Transcriptomic Profiling of Cumulus Cells From CAPA-IVM","Transcriptomic Profiling of Cumulus Cells From CAPA-IVM Cycles in Women With PCOS: A Prospective Pilot Study","Inclusion Criteria:\n\n* Women 18-38 years\n* BMI =\\\u003C 32kg\u002Fm2\n* Diagnosed with polycystic ovary syndrome (PCOS) according to the Rotterdam 2003 criteria, meet at least 2 of the following 3 features: (1) Oligo-ovulation or anovulation. (2) Clinical and\u002For biochemical signs of hyperandrogenism (3) Polycystic ovarian morphology on ultrasound.\n* Indicated for CAPA-IVM treatment.\n* Serum AMH ≥ 4 ng\u002FmL (28.57 pmol\u002FL).\n* Antral follicle count (AFC) ≥ 24 follicles in both ovaries at the time of CAPA-IVM indication.\n* Signed informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Retrieved sperm from surgical procedures\n* Previous IVF cycle with total immature oocytes","FEMALE","18 Years","38 Years",{"count":61,"type":62},10,"ESTIMATED","OBSERVATIONAL","Capacitation in vitro maturation (CAPA-IVM) has improved oocyte maturation and resulted in live births. Because cumulus cells (CCs) communicate bidirectionally with the oocyte, their transcriptomic profile may serve as a non-invasive biomarker of oocyte and embryo competence. This prospective pilot study will analyze CCs gene expression after CAPA-IVM using RNA sequencing and pathway analysis, and correlate findings with embryological outcomes including fertilization, day-3 cleavage, and blastocyst formation. Results are expected to provide insights into the molecular basis of oocyte competence and support development of non-invasive embryo selection strategies.",[66,67,68,69],"PCOS (Polycystic Ovary Syndrome)","Cumulus Cell","Capacitation IVM","Transcriptomic Profiling",[71,72,73,74],"In vitro maturation","CAPA-IVM","Cumulus cells","Transcriptomics","2025-11-20",{"date":77,"type":78},"2025-11-21","ACTUAL",{"date":80,"type":78},"2025-10-16",{"date":82,"type":62},"2026-03-30",{"name":5,"class":6},1]