[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100612656":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":10,"centralContacts":29,"locations":36,"responsibleParty":53,"collaborators":10,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":62,"sex":63,"minAge":64,"maxAge":10,"enrollmentInfo":65,"targetDuration":10,"studyType":68,"phases":10,"briefSummary":69,"conditions":70,"keywords":10,"overallStatus":39,"whyStopped":10,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"Centre Hospitalier Universitaire Dijon","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"scleroderma",null,"People with systemic scleroderma",[13,14],"Procedure: Skin samples","Other: Analysis of fibroblasts",{"label":16,"type":10,"description":17,"interventionNames":18},"Control","People undergoing plastic, cosmetic and reconstructive surgery",[13,14],[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"PROCEDURE","Skin samples","* Scleroderma group: skin biopsy for scleroderma patients\n* Control group: recovery of resected tissue from patients undergoing plastic, reconstructive and aesthetic surgery.",[16,9],{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":10},"Analysis of fibroblasts","Analysis of samples by RNA sequencing",[16,9],[30],{"name":31,"role":32,"phone":33,"phoneExt":34,"email":35},"Bernard BONNOTTE","CONTACT","03.80.29.34.32","+33","Bernard.bonnotte@chu-dijon.fr",[37],{"facility":38,"status":39,"city":40,"state":10,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"CHU Dijon Bourgogne","RECRUITING","Dijon","21000","France","FR",{"type":45,"coordinates":46},"Point",[47,48],5.01391,47.31344,{"lat":48,"lon":47},[51],{"name":52,"role":32,"phone":33,"phoneExt":34,"email":35},"Bernard BONOTTE",{"type":54,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100612656","transcriptomic-study-of-cutaneous-fibroblasts-in-scleroderma-100612656",false,"NCT07256418","Transcriptomic Study of Cutaneous Fibroblasts in Scleroderma","TRANSCLERO","Inclusion Criteria:\n\nFOR PATIENTS WITH SCLERODERMA :\n\n* Person who has given written consent\n* Person with systemic scleroderma\n\nFOR CONTROL PARTICIPANTS :\n\n* Person who has given written consent\n* Person undergoing plastic, cosmetic and reconstructive surgery\n\nExclusion Criteria:\n\nFOR PATIENTS WITH SCLERODERMA :\n\n* Person not affiliated to or not benefiting from a social security scheme\n* Person subject to a legal protection measure (curatorship, guardianship)\n* Person subject to a legal protection measure\n* An adult who is incapable or unable to give consent\n* Minors\n\nFOR CONTROLLED PARTICIPANTS :\n\n* Person suffering from a chronic disease or under chronic treatment for autoimmune, inflammatory or dermatological diseases\n* Person not affiliated to or not benefiting from a social security scheme\n* Person under legal protection (curatorship, guardianship)\n* Person subject to a legal protection measure\n* An adult who is incapable or unable to give consent\n* Minors",true,"ALL","18 Years",{"count":66,"type":67},60,"ESTIMATED","OBSERVATIONAL","Scleroderma is a complex connective tissue disease involving three interconnected pathophysiological axes: vascular hyperactivity and remodelling, immune system dysfunction and over-activation of fibroblasts at the origin of the fibrosis process in the skin and organs. Given that this pathology occurs preferentially in mature subjects, it is possible to suggest a potential inductive role for senescent fibroblasts, which would be responsible for activating and\u002For maintaining the immune response and systemic inflammation. Our hypothesis is that fibroblasts play a predominant role in the genesis and maintenance of this pathology.",[71],"Scleroderma","2026-01-28",{"date":74,"type":75},"2026-01-29","ACTUAL",{"date":77,"type":75},"2026-01-26",{"date":79,"type":67},"2027-01",{"name":5,"class":6},1]