[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100572495":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":30,"responsibleParty":46,"collaborators":20,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":20,"eligibilityCriteria":53,"healthyVolunteers":50,"sex":54,"minAge":55,"maxAge":20,"enrollmentInfo":56,"targetDuration":20,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":32,"whyStopped":20,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},{"fullName":5,"class":6},"IRCCS Azienda Ospedaliero-Universitaria di Bologna","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients with post-OLT rejection","EXPERIMENTAL","The patient will be enrolled in a single visit, as per standard of care, clinical and general data will be collected and the biopsy will be performed",[13],"Diagnostic Test: Molecular diagnostic",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DIAGNOSTIC_TEST","Molecular diagnostic","RNA will be analysed using a Real-Time PCR expression card (TaqMan Real-Time PCR assay technology - Thermo Fisher Scientific). The analysis will be performed using a Real-Time Light Cycler 480 (Roche). The expression card will be customised for the study, including the genes cxcl9\u002F10, cav-1, rhoj, cdh5, cd96, tnfsf8, il-21r, vcam, klrk1",[9],null,[22],{"name":23,"affiliation":5,"role":24},"Deborah Malvi, MD","PRINCIPAL_INVESTIGATOR",[26],{"name":23,"role":27,"phone":28,"phoneExt":20,"email":29},"CONTACT","0512143761","deborah.malvi@aosp.bo.it",[31],{"facility":5,"status":32,"city":33,"state":20,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"RECRUITING","Bologna","40138","Italy","IT",{"type":38,"coordinates":39},"Point",[40,41],11.33875,44.49381,{"lat":41,"lon":40},[44,45],{"name":23,"role":27,"phone":28,"phoneExt":20,"email":29},{"name":23,"role":24,"phone":20,"phoneExt":20,"email":20},{"type":47,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100572495","transcriptomics-as-an-aid-in-the-histological-diagnosis-of-acute-rejection-after-liver-transplantation-100572495",false,"NCT06734013","Transcriptomics as an Aid in the Histological Diagnosis of Acute Rejection After Liver Transplantation","Inclusion Criteria:\n\n* Patients with a diagnosis of post-OLT rejection prior to the visit at which they will be enrolled, with tissue available for RT-PCR investigations\n* Age ≥ 18 years\n* Informed consent\n\nExclusion Criteria:\n\n* Age \\\u003C18 years","ALL","18 Years",{"count":57,"type":58},40,"ESTIMATED","INTERVENTIONAL",[61],"NA","The primary objective of this exploratory study is to identify genes associated with acute rejection in liver transplant patients. To this end, a panel of acute rejection indicator genes (both humoral and cell-mediated) will be selected from results published in the literature and applied to biological material derived from biopsies. The secodnary objective is to identify genes associated with the diagnosis of humoral acute rejection and those associated with the diagnosis of cell-mediated acute rejection.",[64],"Rejection; Transplant, Liver",[66],"Liver transplant","2024-12-10",{"date":69,"type":70},"2024-12-16","ACTUAL",{"date":72,"type":70},"2024-10-17",{"date":74,"type":58},"2025-06",{"name":5,"class":6},1]