[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100635833":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":36,"locations":42,"responsibleParty":56,"collaborators":26,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":26,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":26,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":79,"overallStatus":87,"whyStopped":26,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Second Affiliated Hospital, School of Medicine, Zhejiang University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"taVNS + Cervical Epidural Injection","EXPERIMENTAL","Participants in this group receive 3 consecutive days of preoperative transcutaneous auricular vagus nerve stimulation (taVNS), 1-2 hours per day. The electrode is placed on the left cymba conchae, with parameters set at 30Hz frequency, 200μs pulse width, and current titrated to patient tolerance (maximum 50mA). This is combined with a standard cervical epidural injection of corticosteroid and local anesthetic.",[13,14],"Behavioral: Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)","Procedure: Cervical Epidural Injection",{"label":16,"type":17,"description":18,"interventionNames":19},"Sham taVNS + Cervical Epidural Injection","SHAM_COMPARATOR","Arm Description Participants in this group receive sham taVNS using an identical-appearing inactive device, applied at the same auricular region, for the same duration and frequency as the experimental group.",[13,14],[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)","Preoperative non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) administered for 3 consecutive days, 1-2 hours daily. Electrode placed on the left cymba conchae. Parameters: 30Hz frequency, 200μs pulse width, current titrated to patient tolerance (max 50mA).",[16,9],null,{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":26},"PROCEDURE","Cervical Epidural Injection","Standard cervical epidural injection of corticosteroid and local anesthetic, identical to the experimental group, administered per clinical routine.",[16,9],[33],{"name":34,"affiliation":5,"role":35},"Lina Yu","PRINCIPAL_INVESTIGATOR",[37],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},"Lina Yu, MD","CONTACT","1395803387","zryulina@zju.edu.cn",[43],{"facility":44,"status":26,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":26},"The Second Affiliated Hospital, Zhejiang University School of Medicine Facility Address 88 Jiefang Road, Shangcheng District, Hangzhou, Zhejiang Province, 310009, P.R.China","Hangzhou","Zhejiang","310009","China","CN",{"type":51,"coordinates":52},"Point",[53,54],120.16142,30.29365,{"lat":54,"lon":53},{"type":57,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100635833","transcutaneous-auricular-vagus-nerve-stimulation-combined-with-cervical-epidural-injection-for-cervical-radiculopathy-100635833",false,"NCT07557823","Transcutaneous Auricular Vagus Nerve Stimulation Combined With Cervical Epidural Injection for Cervical Radiculopathy","Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) Combined With Cervical Epidural Injection in the Treatment of Cervical Radiculopathy: A Randomized, Double-Blind, Sham-Controlled Trial.","Inclusion Criteria:\n\n1. Age between 18 and 85 years old.\n2. Body Mass Index (BMI) between 18 and 35 kg\u002Fm².\n3. American Society of Anesthesiologists (ASA) physical status I to III.\n4. Diagnosed with cervical radiculopathy, scheduled for selective cervical epidural injection.\n5. Estimated procedure duration ≤ 1 hour.\n6. Able to understand and provide written informed consent.\n\nExclusion Criteria:\n\n1. Arrhythmia requiring treatment, severe bradycardia, or postural orthostatic tachycardia syndrome.\n2. Neuromuscular disorders or auricular dermatitis.\n3. Cervical fracture, tumor, tuberculosis, or active infection confirmed by imaging.\n4. Contraindications to vagus nerve stimulation: carotid sinus hypersensitivity, bilateral carotid artery stenosis.\n5. Severe psychiatric disorder or history of substance abuse.","ALL","18 Years","85 Years",{"count":69,"type":70},80,"ESTIMATED","INTERVENTIONAL",[73],"NA","This is a prospective, randomized, double-blinded, sham-controlled trial conducted to investigate the efficacy and safety of transcutaneous auricular vagus nerve stimulation (taVNS) combined with cervical epidural injection in the treatment of cervical radiculopathy. A total of 80 subjects will be enrolled and randomly assigned (1:1) to either the experimental group or the control group. The primary outcome measure is the proportion of subjects with a ≥50% reduction in the Numerical Rating Scale (NRS) pain score at discharge. Secondary outcomes include pain intensity, pain interference, psychological status, sleep quality, physical disability, and autonomic function measurements. Adverse events will be monitored throughout the study.",[76,77,78],"Cervical Radiculopathy","Cervical Spondylosis","Radicular Pain",[80,81,82,83,84,85,86],"taVNS","transcutaneous auricular vagus nerve stimulation","cervical epidural injection; cervical radiculopathy","pain","arm pain","pain management","neuromodulation","NOT_YET_RECRUITING","2026-04-26",{"date":90,"type":91},"2026-04-29","ACTUAL",{"date":93,"type":70},"2026-04-10",{"date":95,"type":70},"2027-03-31",{"name":5,"class":6},1]