[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100479001":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":34,"locations":39,"responsibleParty":56,"collaborators":25,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":25,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":41,"whyStopped":25,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"VA Office of Research and Development","FED",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"tcVNS","EXPERIMENTAL","Stimulation twice daily with transcutaneous Vagal Nerve Stimulation (tcVNS)",[13],"Device: tcVNS",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham","ACTIVE_COMPARATOR","Stimulation with sham",[19],"Device: Sham",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Active stimulation with transcutaneous Vagal Nerve Stimulation (tcVNS)",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"Sham stimulation",[15],[30],{"name":31,"affiliation":32,"role":33},"Doug J Bremner, MD","Atlanta VA Medical and Rehab Center, Decatur, GA","PRINCIPAL_INVESTIGATOR",[35],{"name":31,"role":36,"phone":37,"phoneExt":25,"email":38},"CONTACT","(404) 712-9569","James.Bremner@va.gov",[40],{"facility":32,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"RECRUITING","Decatur","Georgia","30033-4004","United States","US",{"type":48,"coordinates":49},"Point",[50,51],-84.29631,33.77483,{"lat":51,"lon":50},[54,55],{"name":31,"role":36,"phone":37,"phoneExt":25,"email":38},{"name":31,"role":33,"phone":25,"phoneExt":25,"email":25},{"type":57,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100479001","transcutaneous-vagal-nerve-stimulation-in-veterans-with-posttraumatic-stress-disorder-100479001",false,"NCT05517304","Transcutaneous Vagal Nerve Stimulation in Veterans With Posttraumatic Stress Disorder","VNS in PTSD","Inclusion Criteria:\n\n* Veterans between the ages of 18 and 75 will be included with a diagnosis of PTSD based on DSM-5 criteria\n\nExclusion Criteria:\n\nSubjects will be excluded with:\n\n* a history of mild traumatic brain injury (mTBI) based on VA Criteria\n* moderate or greater TBI\n* positive pregnancy test\n* meningitis or other neurological disorder\n* alcohol or substance abuse use disorder based on DSM-5 criteria within the past 12 months\n* current or lifetime history of schizophrenia, schizoaffective disorder, bipolar I disorder, anorexia nervosa or bulimia, based on DSM-5\n* active suicidal ideation with a plan\n* a history of serious medical or neurological illness, such as cardiovascular, gastrointestinal, hepatic, renal, neurologic or other systemic illness that would preclude participation based on clinical judgment of the PI\n* active opiate or benzodiazepine treatment\n* history of structural abnormality on brain MRI or CT if one has been performed in the past","ALL","18 Years","75 Years",{"count":69,"type":70},80,"ESTIMATED","INTERVENTIONAL",[73],"NA","This study effects the effects of transcutaneous cervical vagal nerve stimulation (tcVNS) or a sham control on brain, physiology, and PTSD symptoms in Veterans with posttraumatic stress disorder (PTSD). Veterans undergo brain imaging and physiological measures in conjunction with traumatic scripts before and after three months of twice daily treatment with tcVNS or sham stimulation at home.",[76],"Stress Disorders, Post-Traumatic",[76,78,79],"PTSD","Vagus Nerve","2026-02-27",{"date":82,"type":83},"2026-03-03","ACTUAL",{"date":85,"type":83},"2022-10-01",{"date":87,"type":70},"2027-11-10",{"name":5,"class":6},1]