[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100571777":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":29,"locations":35,"responsibleParty":60,"collaborators":18,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":66,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":18,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":88,"overallStatus":56,"whyStopped":18,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Babes-Bolyai University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Transdiagnostic Internet-delivered intervention","EXPERIMENTAL","The intervention consists of 8 modules delivered over 8 weeks. It is based on Rational Emotive Behavioral Therapy (REBT).",[13],"Behavioral: Transdiagnostic Internet-delivered intervention",{"label":15,"type":16,"description":17,"interventionNames":18},"Control group","NO_INTERVENTION","Participants in the control group are a delayed intervention group (waiting list control). They will access the intervention after 8 weeks.",null,[20],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":18},"BEHAVIORAL","The intervention consists of 8 modules based on Rational emotive therapy, delivered via 8 weeks.",[9],[25],{"name":26,"affiliation":27,"role":28},"Costina Poetar, PhD","Babeș-Bolyai University","STUDY_CHAIR",[30],{"name":31,"role":32,"phone":33,"phoneExt":18,"email":34},"Kristoffer Mansson, PhD","CONTACT","+46705803267","nils.mansson@ubbcluj.ro",[36,55],{"facility":5,"status":37,"city":38,"state":18,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"NOT_YET_RECRUITING","Cluj-Napoca","400015","Romania","RO",{"type":43,"coordinates":44},"Point",[45,46],23.6,46.76667,{"lat":46,"lon":45},[49,53],{"name":50,"role":32,"phone":51,"phoneExt":18,"email":52},"Costina R Poetar, Ph.D","+ 40743589465","costinapoetar@psychology.ro",{"name":50,"role":54,"phone":18,"phoneExt":18,"email":18},"SUB_INVESTIGATOR",{"facility":27,"status":56,"city":38,"state":18,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":57,"geoPoint":59,"contacts":18},"RECRUITING",{"type":43,"coordinates":58},[45,46],{"lat":46,"lon":45},{"type":61,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"PRINCIPAL_INVESTIGATOR","Costina-Ruxandra Poetar","Assistant professor","100571777","transdiagnostic-internet-delivered-intervention-for-adolescents-with-anxiety-and-depression-100571777",false,"NCT06724666","Transdiagnostic Internet-delivered Intervention for Adolescents With Anxiety and Depression","NEURO4C","Inclusion Criteria:\n\n* elevated symptoms of anxiety or depression\u002F internalizing problems (T score\\> 60) at intake (based on Youth self-report completed by adolescents)\n* primary diagnosis of an anxiety\u002Fdepressive disorder based on DSM-5 criteria according to ADIS-5-C\u002FP interview\n* age 13-17\n* able to read and understand Romanian language\n* Currently unmedicated or on stable and adequate doses of medication for at least 6 weeks before treatment onset\n* Internet access\n\nExclusion Criteria:\n\n* severe mental disorder (psychosis, severe depression, bipolar disorder, based on clinical interview)\n* any condition that interferes with the protocol implementation (e.g., physical illness or sensory impairment that interferes with behavioral tasks such as exposure, behavioral activation, unavailable for the next 3 months),\n* active suicidal ideation (assessed by child psychiatrist during clinical interview) in the last month\n* currently following CBT\u002F psychotherapy for anxiety\u002Fdepression, in the last 6 months\n* fMRI incompatible (based on safety questionnaire)\n* Being diagnosed with an intellectual disability, pervasive developmental disorder, an alcohol and\u002For substance dependence disorder, reading disabilities (based on clinical interview).\n* Current treatment with benzodiazepines","ALL","13 Years","17 Years",{"count":75,"type":76},198,"ESTIMATED","INTERVENTIONAL",[79],"NA","The goal of this clinical trial is to test the efficacy of a transdiagnostic Internet-delivered interventions for Romanian adolescents with anxiety and\u002F or depression. The main questions it aims to answer are:\n\n* What is the clinical efficacy of the Internet-delivered intervention?\n* How accurate is the prediction model in predicting who will respond to treatment? Participants will undergo non-invasive fMRI to measure variability in brain signal as a proxy of the neural systems' adaptability before receiving the intervention, then they will be allocated either to the Internet-delivered intervention or control group.",[82,83,84,85,86,87],"Anxiety Disorders","Depressive Disorder","Social Anxiety Disorder","Major Depressive Disorder","Dysthymia","Generalized Anxiety Disorder",[89,90,91,92,93,94],"Internet-delivered intervention","transdiagnostic","adolescents","internalizing","anxiety","depression","2025-04-02",{"date":97,"type":98},"2025-04-04","ACTUAL",{"date":100,"type":98},"2025-04-01",{"date":102,"type":76},"2026-06-30",{"name":5,"class":6},2]