[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100606288":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":18,"responsibleParty":38,"collaborators":41,"id":44,"slug":45,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":51,"sex":52,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":18,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":66,"overallStatus":77,"whyStopped":18,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":18},{"fullName":5,"class":6},"Beth Israel Deaconess Medical Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention","EXPERIMENTAL","Intervention participants will take the Inner Engineering program and are asked to practice meditation daily for the duration of the study.",[13],"Behavioral: Inner Engineering Program",{"label":15,"type":16,"description":17,"interventionNames":18},"Control","NO_INTERVENTION","Control participants will be asked to continue their daily routine",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"BEHAVIORAL","Inner Engineering Program","The intervention is a comprehensive secular training called Inner Engineering (IE), offered by the international non-profit Isha Foundation. This program combines cognitive reappraisal and emotion regulation strategies, breath-based meditation and simple yoga practices. The training provides precise, step by step and easy to follow instructions on how to perform the practices. No previous experience of yoga and meditation is required. By fostering health, exuberance and awareness, one can \"engineer their inner climate the way they want it\" to lead a joyful, fulfilling life. Previous research shows improved wellbeing, mindfulness, joy, sleep, relationships, psychological capital, and work engagement, compassion, and parent-child relationships. Evidence suggest it may promote enhanced Heart Rate Variability and Sympathovagal balance.",[9],[26],{"name":27,"affiliation":28,"role":29},"Sepideh Hariri, PhD","Beth Israel Deaconess Medical Centre, Boston, Massachusetts 02115","PRINCIPAL_INVESTIGATOR",[31,35],{"name":27,"role":32,"phone":33,"phoneExt":18,"email":34},"CONTACT","617-278-8082","sadhgurucenter_research@bidmc.harvard.edu",{"name":36,"role":32,"phone":37,"phoneExt":18,"email":34},"Balachundhar Subramaniam, MD, MPH","617-667-2721",{"type":29,"investigatorFullName":39,"investigatorTitle":40,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Sepideh Hariri","Instructor in Anesthesia at Harvard Medical School, Program Manager at Department of Anesthesia, Beth Israel Deaconess Medical Center",[42],{"name":43,"class":6},"Tiny Blue Dot Foundation","100606288","transforming-adolescent-perception-and-mental-health-through-meditation-and-cognitive-reappraisal-a-mixed-method-study-100606288",false,"NCT07173608","Transforming Adolescent Perception and Mental Health Through Meditation and Cognitive Reappraisal A Mixed Method Study","THRIVE","Inclusion Criteria:\n\n* Individuals between15-18 years of age\n* Ability to understand study instructions and provide informed consent\u002Fassent. (parental consent for minors)\n* Access to internet and a device to complete online study activities\n* Currently residing in the United States\n* Willing and able to travel to the hospital location in Boston for study procedures.\n\nExclusion Criteria:\n\n* Non-English speaking (Justification: the intervention and assessment instruments are not validated in a sufficient range of languages, and the research team lacks polylingual capabilities or the financial resources to hire interpreters for the duration of all proposed assessments.)\n* Practicing meditation regularly in the past 6 months (4 or more times per week for 4 weeks or more in the past 6 months)\n* History of psychiatric illness such as severe anxiety, severe depression, posttraumatic stress disorder (PTSD), Schizophrenia or bipolar disorder\n* Current use of cognition enhancing drugs\n* Current management for chronic pain\n* History (within past 5 years) of seizure, brain surgery or any condition causing cognitive decline.\n* Active history (within the last 5 years) of alcohol or drug abuse.\n* Current pregnancy or planning to become pregnant in the next 6 months\n* Currently enrolled in another interventional study that could impact the primary outcome, as determined by the PI\n* Significant visual impairment\n* Subject has previously learned the intervention.\n* Subject has contraindications for MRI (Detailed in the eligibility screening questions)",true,"ALL","15 Years","18 Years",{"count":56,"type":57},96,"ESTIMATED","INTERVENTIONAL",[60],"NA","This study will evaluate how a comprehensive meditation-based program, Inner Engineering, supports teens ages 15-18 in becoming more joyful, focused, resilient, and better equipped to manage stress and thrive. Through this study, researchers will examine whether practices like meditation, yoga, and cognitive reframing can help adolescents view and respond to challenges with greater clarity and balance. The study will assess mental and physical impacts through self-report, physiological, and neuroimaging methods.",[63,64,65],"Meditation","Cognitive Reappraisal","Emotional Regulation",[67,68,69,70,71,72,73,74,75,76],"meditation","Inner Engineering","Shambhavi Mahamudra Kriya","EEG","Functional MRI","MRI","Cognition","Mindfulness","Mental Health","Adolescent","NOT_YET_RECRUITING","2026-04-22",{"date":80,"type":81},"2026-04-23","ACTUAL",{"date":83,"type":57},"2026-05",{"date":85,"type":57},"2028-03",{"name":5,"class":6}]