[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100541644":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":28,"centralContacts":33,"locations":40,"responsibleParty":67,"collaborators":24,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":71,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":24,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":90,"overallStatus":94,"whyStopped":24,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Guangdong Provincial People's Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Restrictive transfusion strategy","ACTIVE_COMPARATOR","Restrictive transfusion strategy: Blood transfusion triggers of Hb valve less than 6.0g\u002FdL or Hct value less than 18% during CPB, Hb valve less than 7.0g\u002FdL or Hct value less than 21% in ICU or general ward.\n\nRed blood cell transfusion will be given when Hct values fall below 18% or Hb fall below 6.0g\u002FdL during CPB, 2 units RBC transfusion will be administered. In ICU or general ward after surgery, RBC transfusion will be given when Hct values fall below 21% or Hb fall below 7.0g\u002FdL during CPB, 2 unit RBC transfusion will be administered. Following administration of the 2 units transfusion a repeat HCT or Hb is performed, if their values greater than threshold, no further transfusions will be administered, or will be received 2 units RBC again.",[13],"Other: Restrictive Transfusion Strategy",{"label":15,"type":10,"description":16,"interventionNames":17},"Liberal Transfusion Strategy","Liberal Transfusion Strategy: Blood transfusion triggers of Hb valve less than 8.0g\u002FdL or Hct value less than 24% during CPB, Hb valve less than 10.0g\u002FdL or Hct value less than 30% in ICU or general ward.\n\nRed blood cell transfusion will be given when Hct values fall below 24% or Hb fall below 8.0g\u002FdL during CPB, 2 units RBC transfusion will be administered. In ICU or general ward after surgery, RBC transfusion will be given when Hct values fall below 30% or Hb fall below 10.0g\u002FdL during CPB, 2 units RBC transfusion will be administered. Following administration of the 2 units transfusion a repeat HCT or Hb is performed, if their values greater than threshold, no further transfusions will be administered, or will be received 2 units RBC again.",[18],"Other: Liberal Transfusion Strategy",[20,25],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Restrictive Transfusion Strategy","Blood transfusion at HCT less than 21% or Hb less than 6.0g\u002FdL during CPB, at HCT less than 21% or Hb less than 7.0g\u002FdL in ICU or general ward after surgery",[9],null,{"type":6,"name":15,"description":26,"armGroupLabels":27,"otherNames":24},"Blood transfusion at HCT less than 24% or Hb less than 8.0g\u002FdL during CPB, at HCT less than 30% or Hb less than 10.0g\u002FdL in ICU or general ward after surgery",[15],[29],{"name":30,"affiliation":31,"role":32},"Huang Huanlei, Phd","hhuanlei@hotmail.com","PRINCIPAL_INVESTIGATOR",[34,37],{"name":30,"role":35,"phone":36,"phoneExt":24,"email":31},"CONTACT","765-714-9765",{"name":38,"role":35,"phone":36,"phoneExt":24,"email":39},"Zhang Zhaolong, BD","zhangzhlong1104@163.com",[41],{"facility":5,"status":24,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Guangzhou","Guangdong","510145","China","CN",{"type":48,"coordinates":49},"Point",[50,51],113.25,23.11667,{"lat":51,"lon":50},[54,56,58,60,62,63,65],{"name":30,"role":35,"phone":55,"phoneExt":24,"email":31},"765 714 9765",{"name":57,"role":32,"phone":24,"phoneExt":24,"email":24},"Huang huanlei, Phd",{"name":59,"role":32,"phone":24,"phoneExt":24,"email":24},"Zhao Junfei, Phd",{"name":61,"role":32,"phone":24,"phoneExt":24,"email":24},"He Biaochuan, Phd",{"name":38,"role":32,"phone":24,"phoneExt":24,"email":24},{"name":64,"role":32,"phone":24,"phoneExt":24,"email":24},"Wang Zhenzhong, MD",{"name":66,"role":32,"phone":24,"phoneExt":24,"email":24},"Wang Qiuji, MD",{"type":68,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR","100541644","transfusion-in-cardiac-valve-surgery-100541644",false,"NCT06332547","Transfusion in Cardiac Valve Surgery","A Multicenter Prospective, Randomized Controlled Study of Different Transfusion Thresholds in Cardiac Valve Surgery","TICVS","Inclusion Criteria:\n\n* All cardiac valve surgical patients undergoing CPB, isolated valve procedures Informed consent obtained\n\nExclusion Criteria:\n\n* Pregnant or maternal women Age less than 18 years or more than 80 years Undergo coronary artery bypass or large cardiac vessels procedure Emergencies Have been attended other researches Unable to receive blood for religious reasons Drug addict or malignant tumor patient","ALL","18 Years","80 Years",{"count":81,"type":82},1600,"ESTIMATED","INTERVENTIONAL",[85],"NA","This prospective, randomized controlled study is aimed to figure out suitable transfusion threshold in patients undergoing cardiac valve surgery under cardiopulmonary bypass(CPB). Patients are randomly assigned to restrictive and liberal transfusion group and receive blood transfusion during and after surgery. Compare primary and secondary outcomes of two groups.",[88,89],"Cardiac Surgery With Cardiopulmonary Bypass","Valve Heart Disease",[91,92,93],"cardiac valve surgery","transfusion","transfusion threshold","NOT_YET_RECRUITING","2024-03-26",{"date":97,"type":98},"2024-03-27","ACTUAL",{"date":100,"type":82},"2024-04-01",{"date":102,"type":82},"2027-12-30",{"name":5,"class":6},1]