[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100540138":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":18,"centralContacts":23,"locations":32,"responsibleParty":56,"collaborators":58,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":66,"sex":71,"minAge":72,"maxAge":10,"enrollmentInfo":73,"targetDuration":10,"studyType":76,"phases":10,"briefSummary":77,"conditions":78,"keywords":80,"overallStatus":34,"whyStopped":10,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Assistance Publique - Hôpitaux de Paris","OTHER",[8],{"label":9,"type":10,"description":9,"interventionNames":11},"Patients with various bone and joint diseases",null,[12],"Other: Collection of joint fluid or tissue sample",[14],{"type":6,"name":15,"description":16,"armGroupLabels":17,"otherNames":10},"Collection of joint fluid or tissue sample","During a puncture or joint surgery planned as part of the routine care of the patient, a part of the joint fluid or tissue sample will be collected in order to carry out the analyzes planned for the research.",[9],[19],{"name":20,"affiliation":21,"role":22},"Christelle Nguyen, MD, PhD","Service de Médecine Physique et de Réadaptation, Hôpital Cochin","PRINCIPAL_INVESTIGATOR",[24,28],{"name":20,"role":25,"phone":26,"phoneExt":10,"email":27},"CONTACT","00 33 1 58 41 29 45","christelle.nguyen2@aphp.fr",{"name":29,"role":25,"phone":30,"phoneExt":10,"email":31},"Marie Benhammani-Godard","00 33 1 58 41 11 90","marie.godard@aphp.fr",[33],{"facility":21,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"RECRUITING","Paris","IDF","75014","France","FR",{"type":41,"coordinates":42},"Point",[43,44],2.3488,48.85341,{"lat":44,"lon":43},[47,48,51,54],{"name":20,"role":25,"phone":26,"phoneExt":10,"email":27},{"name":49,"role":25,"phone":10,"phoneExt":10,"email":50},"François RANNOU, MD, PhD","francois.rannou@aphp.fr",{"name":52,"role":53,"phone":10,"phoneExt":10,"email":10},"François Rannou, MD, PhD","SUB_INVESTIGATOR",{"name":55,"role":53,"phone":10,"phoneExt":10,"email":10},"Didier Borderie, MD, PhD",{"type":57,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[59,62],{"name":60,"class":61},"Institut National de la Santé Et de la Recherche Médicale, France","OTHER_GOV",{"name":63,"class":6},"URC-CIC Paris Descartes Necker Cochin","100540138","translating-articular-biomarkers-into-diagnoses-100540138",false,"NCT06312943","\"Translating Articular Biomarkers Into Diagnoses\"","ARTBioSes","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Inflammatory and non-inflammatory bone and joint diseases requiring synovial fluid aspiration and\u002For joint replacement\n* Collection of non-opposition\n* Affiliated to or beneficiary of social security\n\nExclusion Criteria:\n\n* Inability to speak and\u002For read French\n* Neoadjuvant therapy\n* Patients under tutor or curatorship\n* Protected adults,\n* Patients benefiting of State Medical Aid","ALL","18 Years",{"count":74,"type":75},50,"ESTIMATED","OBSERVATIONAL","Early diagnosis is a key factor in the prevention and management of rheumatic diseases. Rheumatic diseases are classically diagnosed based on criteria combining clinical, biological and radiological features. However, in up to 20% of the cases, diagnoses remain unstated and underlying rheumatic diseases unclassified, which might lead to delayed specific treatment and unfavourable clinical outcomes. In addition, conventional methods could lack sensitivity and specificity for early diagnosis. Biological samples are attractive targets for the early detection of articular damage because they allow for collection of multiple levels of information from the clinic and the laboratory\\]. Biological samples most frequently collected from patients with rheumatic diseases are synovial fluid by joint aspiration, blood by venous puncture and tissue specimen by surgery. The investigators hypothesize that in challenging situations, novel biomarkers detected from synovial fluid or articular tissues using both conventional (e.g. histology, immunodetection, PCR) and innovative (e.g. Raman spectroscopy, nanospectroscopy) laboratory tests may help refining diagnosis and better classifying patients with rheumatic diseases.",[79],"Inflammatory and Non-inflammatory Bone and Joint Diseases",[81,82,83,84,85],"Osteoarthritis","Rheumatoid arthritis","Inflammatory joint disorders","RAMAN spectroscopy","Biomarkers","2026-06-22",{"date":88,"type":89},"2026-06-24","ACTUAL",{"date":91,"type":89},"2026-06-02",{"date":93,"type":75},"2029-08",{"name":5,"class":6},1]