[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100462387":3},{"organization":4,"armGroups":7,"interventions":34,"overallOfficials":40,"centralContacts":44,"locations":49,"responsibleParty":65,"collaborators":10,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":76,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":83,"studyType":84,"phases":10,"briefSummary":85,"conditions":86,"keywords":99,"overallStatus":52,"whyStopped":10,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":115},{"fullName":5,"class":6},"The University of Hong Kong","OTHER",[8,14,18,22,26,30],{"label":9,"type":10,"description":11,"interventionNames":12},"Haemorrhagic Stroke [N=100]",null,"Haemorrhagic stroke subjects presenting within 24 hours from symptom onset will have serial whole blood and saliva drawn a) in the emergency department (if available) or hospital within 24 hours of the onset of symptoms; b) 18 hours +\u002F- 6 hours from symptom onset (if available); and c) 30 hours+\u002F- 6 hours from symptom onset (if available).",[13],"Diagnostic Test: Biomarker blood draw and saliva collection",{"label":15,"type":10,"description":16,"interventionNames":17},"Acute Ischaemic Stroke [N=300]","Acute Ischaemic stroke subjects presenting within 24 hours from symptom onset will have serial whole blood and saliva drawn a) in the emergency department (if available) or hospital within 24 hours of the onset of symptoms; b) 18 hours +\u002F- 6 hours from symptom onset (if available); and c) 30 hours+\u002F- 6 hours from symptom onset (if available).",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Stroke of uncertain origin [N=45]","Stroke of uncertain origin subjects presenting within 24 hours from symptom onset will have serial whole blood and saliva drawn a) in the emergency department (if available) or hospital within 24 hours of the onset of symptoms; b) 18 hours +\u002F- 6 hours from symptom onset (if available); and c) 30 hours+\u002F- 6 hours from symptom onset (if available).",[13],{"label":23,"type":10,"description":24,"interventionNames":25},"Transient Ischemic Attack (TIA) [N=75]","TIA subjects presenting within 24 hours from symptom onset will have serial whole blood and saliva drawn a) in the emergency department (if available) or hospital within 24 hours of the onset of symptoms; b) 18 hours +\u002F- 6 hours from symptom onset (if available); and c) 30 hours+\u002F- 6 hours from symptom onset (if available).",[13],{"label":27,"type":10,"description":28,"interventionNames":29},"Stroke Mimics [N=30]","Stroke Mimics subjects presenting within 24 hours from symptom onset will have serial whole blood and saliva drawn a) in the emergency department (if available) or hospital within 24 hours of the onset of symptoms; b) 18 hours +\u002F- 6 hours from symptom onset (if available); and c) 30 hours+\u002F- 6 hours from symptom onset (if available).",[13],{"label":31,"type":10,"description":32,"interventionNames":33},"Control Subjects [N=100]","Control group subjects, if they agree, will have serial whole blood and saliva drawn a) in the emergency department (if available) or hospital on day 1; b) 18 hours +\u002F- 6 hours after sample 1 (if available); and c) 30 hours+\u002F- 6 hours after sample 1 (if available).",[13],[35],{"type":36,"name":37,"description":38,"armGroupLabels":39,"otherNames":10},"DIAGNOSTIC_TEST","Biomarker blood draw and saliva collection","Three peripheral 10mL blood sample (if available) Three 1 - 3mL salivary samples (if available)",[15,31,9,27,19,23],[41],{"name":42,"affiliation":5,"role":43},"Timothy H Rainer, MD","PRINCIPAL_INVESTIGATOR",[45],{"name":42,"role":46,"phone":47,"phoneExt":10,"email":48},"CONTACT","+852 39176846","thrainer@hku.hk",[50],{"facility":51,"status":52,"city":53,"state":10,"zip":10,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"Hong Kong University","RECRUITING","Hong Kong","China","CN",{"type":57,"coordinates":58},"Point",[59,60],114.17469,22.27832,{"lat":60,"lon":59},[63],{"name":42,"role":46,"phone":64,"phoneExt":10,"email":48},"852 39176846",{"type":43,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Prof. Timothy Hudson RAINER","Professor of Emergency Medicine","100462387","translational-immunodiagnostics-in-stroke-trims-100462387",false,"NCT05300997","Translational Immunodiagnostics in Stroke (TrImS)","Translational Immunodiagnostics in Suspected Stroke (TrImS): A Two-centre, Pragmatic, Prospective, Observational Study","TrImS","Inclusion Criteria:\n\n* Patients eligible for enrolment include:\n\n  * Adults ≥18 years of age.\n  * Suspected acute stroke. Defined as either FAST-positive, or LAPSS-positive or ROSIER\\>0\n  * Within 24 hours of symptom onset.\n  * Informed consent.\n* Control subjects will be drawn from two groups:\n\n  * Non-neurologic patients who are matched with TIA and stroke cases (AIS, HS) for age, race, gender and smoking plus one or more of the following vascular risk factors: diabetes, hypertension, atrial fibrillation, hyperlipidaemia.\n  * Relatives or accompanying friends.\n* Note that we will include and collect samples from the following cases if they present as suspected stroke and are recruited \\\u003C24 hours from symptom onset.\n\n  * Any central nervous system infection, i.e. meningitis or encephalitis in the past 30 days\n  * Any form of head trauma, stroke or intracranial haemorrhage in the past 30 days\n  * Known primary or metastatic cancer involving the brain\n  * Active cancer is defined as a diagnosis of cancer, within 6 months before enrollment, any treatment for cancer within the previous 6 months, or recurrent or metastatic cancer.\n  * Autoimmune diseases: such as lupus, rheumatoid arthritis, Crohn's disease, ulcerative colitis\n  * Active infectious diseases (e.g. HIV\u002FAIDS, hepatitis C)\n  * Major surgery within three months prior to the index event\n\nExclusion Criteria:\n\n* Clear onset of acute symptoms \\>24 hours.",true,"ALL","18 Years","100 Years",{"count":81,"type":82},650,"ESTIMATED","1 Year","OBSERVATIONAL","In adult patients presenting to emergency departments within 24 hours of symptom onset with suspected acute stroke, we aim:\n\n1. to identify early brain- and pathology-specific circulating, whole blood, plasma and serum panorOmic biomarkers that enable early acute stroke detection, diagnosis, dynamics, differentiation, monitoring, prediction and prognosis.\n2. to identify early brain- and pathology-specific, panorOmic biomarkers in saliva that enable early acute stroke detection, diagnosis, dynamics, differentiation, monitoring, prediction and prognosis.\n3. to derive biomarker platforms of models for early acute stroke detection, diagnosis, dynamics, differentiation, monitoring, prediction and prognosis\n4. to validate these models in independent and external datasets",[87,88,89,90,91,92,93,94,95,96,97,98],"Acute Ischemic Stroke","Haemorrhagic Stroke","Transient Ischemic Attacks","Cardioembolic Stroke","Large-Artery Atherosclerosis (Embolus\u002FThrombosis)","Small Vessel Disease","Stroke of Other Determined Etiology","Stroke of Undetermined Etiology","Atrial Fibrillation","Stroke of Anterior Cerebral Artery","Stroke of Middle Cerebral Artery","Stroke of Basilar Artery",[100,101,102,103,104,105],"acute stroke","emergency medicine","diagnostics","molecular","genomics and transcriptomics","proteomics","2026-05-07",{"date":108,"type":109},"2026-05-11","ACTUAL",{"date":111,"type":109},"2022-05-01",{"date":113,"type":82},"2027-08-31",{"name":5,"class":6},1]