[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100556176":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":7,"centralContacts":7,"locations":7,"responsibleParty":8,"collaborators":7,"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":14,"acronym":7,"eligibilityCriteria":15,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":7,"enrollmentInfo":18,"targetDuration":7,"studyType":21,"phases":7,"briefSummary":22,"conditions":23,"keywords":28,"overallStatus":32,"whyStopped":7,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":7},{"fullName":5,"class":6},"Peking Union Medical College Hospital","OTHER",null,{"type":9,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100556176","translational-study-of-mss-tp53-mutation-and-chromosome-instability-relationship-in-endometrial-carcinoma-100556176",false,"NCT06521684","Translational Study of MSS, TP53 Mutation and Chromosome Instability Relationship in Endometrial Carcinoma","Inclusion Criteria:\n\n* willing to participate in the study and sign the informed consent\n* age ≥18 years old\n* researchers evaluated that it was suitable to participate in this translational study\n* Endometrial cancer was confirmed histologically\n* histopathological molecular classification was consistent with pMMR type and POLE wild type\n* The tumor tissue obtained by operation was the primary lesion\n\nExclusion Criteria:\n\n* Received chemotherapy within 14 days prior to sample collection, or received anti-tumor drug therapy such as radiotherapy, biotherapy, endocrine therapy, targeted therapy, immunotherapy, within 21 days prior to sample collection\n* previously treated with KIF18A inhibitors\n* researchers believed that the subjects were not suitable for the translational study for other reasons","FEMALE","18 Years",{"count":19,"type":20},110,"ESTIMATED","OBSERVATIONAL","The objective is to understand the relationship between TP53 mutation, MSS and chromosome instability in endometrial cancer and the effect on clinical prognosis.We will collect a small amount of tumor tissue samples. NGS panel detection and WGD\u002FAS analysis were performed on the tissue. Paracancer tissue was used as a negative control and relevant information in medical records during the operation. Then we will collect clinical diagnosis and disease information through telephone follow-up after the completion of the operation.",[24,25,26,27],"Endometrial Neoplasms","TP53 Gene Mutation","Chromosomal Instability","Microsatellite Stable Endometrial Carcinoma",[29,26,30,25,31],"Endometrial Cancer","microsatellite stability","Whole genome duplication","NOT_YET_RECRUITING","2024-07-22",{"date":35,"type":36},"2024-07-26","ACTUAL",{"date":38,"type":20},"2024-09-01",{"date":40,"type":20},"2025-06-01",{"name":5,"class":6}]