[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642290":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":26,"responsibleParty":42,"collaborators":26,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":26,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":54,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":26,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":26,"overallStatus":69,"whyStopped":26,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":26},{"fullName":5,"class":6},"Qianfoshan Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Control Group (Routine Monitoring Group)","ACTIVE_COMPARATOR","After endotracheal extubation, the sampling end of the sampling line is placed between the patient's mouth and nose, and oxygen is delivered at 2 L\u002Fmin via the sampling line. The patient receives only routine monitoring (including continuous pulse oximetry and clinical observation) and is not connected to the end-tidal carbon dioxide (EtCO₂) monitoring device.",[13],"Other: Routine Monitoring",{"label":15,"type":16,"description":17,"interventionNames":18},"Experimental Group (EtCO₂ Monitoring Group)","EXPERIMENTAL","After endotracheal extubation, the sampling end of the sampling line is placed between the patient's mouth and nose, and oxygen is delivered at 2 L\u002Fmin via the sampling line. At the same time, the sampling line is connected to the monitor to initiate continuous real-time transnasal microstream end-tidal carbon dioxide monitoring.",[19],"Device: EtCO₂ Monitoring",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","EtCO₂ Monitoring","After extubation, the sampling line is placed between the patient's mouth and nose to deliver oxygen at 2 L\u002Fmin. The sampling line is connected to a patient monitor (RespArrayTM) to initiate continuous real-time transnasal microstream end-tidal carbon dioxide (EtCO₂) monitoring throughout the post-anesthesia care unit (PACU) stay.",[15],null,{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Routine Monitoring","After extubation, the sampling line is placed between the patient's mouth and nose to deliver oxygen at 2 L\u002Fmin. The patient receives routine monitoring including continuous pulse oximetry (SpO₂) and clinical observation, but is not connected to the EtCO₂ monitoring device.",[9],[32],{"name":33,"affiliation":34,"role":35},"Jianbo WU, Doctoral","Shandong First Medical University","PRINCIPAL_INVESTIGATOR",[37],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},"Jianbo WU","CONTACT","18560083793","jianbowu@sdu.edu.cn",{"type":43,"investigatorFullName":44,"investigatorTitle":45,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"SPONSOR_INVESTIGATOR","Jianbo Wu","Department Director","100642290","transnasal-microstream-etco2-reduces-hypoxemia-during-emergence-in-aged-post-abdomen-surgery-100642290",false,"NCT07652385","Transnasal Microstream EtCO2 Reduces Hypoxemia During Emergence in Aged Post-Abdomen Surgery","Effect of Transnasal Microstream Capnography on Incidence of Hypoxemia During Emergence From General Anesthesia in Elderly Patients After Abdominal Surgery: A Prospective Randomised Controlled Trial","Inclusion Criteria:\n\n* Age 65-80 years;\n* ASA physical status I-III;\n* BMI 18-30 kg\u002Fm²;\n* Participants scheduled for elective laparoscopic surgery under general anesthesia with endotracheal intubation;\n* Willing to participate in the study and provide written informed consent\n\nExclusion Criteria:\n\n* Patients with nasal bleeding, nasal mucosal injury, nasal cavity occupancy, or other conditions that preclude transnasal carbon dioxide monitoring;\n* Patients undergoing emergency surgery;\n* Participants requiring postoperative assisted ventilation via endotracheal intubation or tracheostomy;\n* Presence of any disease or condition that may cause abnormal end-tidal carbon dioxide waveforms or abnormal baseline pulse oximetry (e.g., congenital heart disease or chronic lung disease);\n* Severe cardiac insufficiency (≤4 Metabolic Equivalents \\[MetS\\]);\n* Severe renal insufficiency (acute kidney injury \\[AKI\\] or chronic kidney disease \\[CKD\\] stage 4 or higher);\n* Severe hepatic insufficiency (Child-Pugh class C or worse);\n* Allergy to study medications;\n* Daily alcohol intake ≥60 grams;\n* History of psychiatric disorders such as depression, severe central nervous system depression, Parkinson's disease, basal ganglion lesions, schizophrenia, epilepsy, Alzheimer's disease;\n* Participation in another related clinical study within the past 3 months.",true,"ALL","65 Years","80 Years",{"count":58,"type":59},324,"ESTIMATED","INTERVENTIONAL",[62],"NA","This prospective, randomized controlled study aims to investigate whether transnasal microstream end-tidal carbon dioxide (EtCO₂) monitoring in the post-anesthesia care unit (PACU) reduces the incidence of postoperative hypoxemia in elderly patients (65-80 years, ASA I-III, BMI 18-30 kg\u002Fm²) undergoing elective laparoscopic surgery under general anesthesia with endotracheal intubation. A total of 324 patients will be randomized 1:1 to either the control group (standard SpO₂ monitoring and clinical observation with oxygen delivery at 2 L\u002Fmin via sampling line) or the experimental group (same oxygen delivery plus continuous real-time transnasal microstream EtCO₂ monitoring). The primary outcome is the incidence of hypoxemia (SpO₂ \\\u003C 90% for \\>15 seconds) after extubation in the PACU. Secondary outcomes include severe hypoxemia (SpO₂ \\\u003C 85%), lowest SpO₂ during PACU stay, vital signs at specified time points, PACU length of stay, and other adverse events. Statistical analysis will use chi-square or Fisher's exact test for the primary outcome, with a sample size calculated to detect a reduction in hypoxemia from 33% (control) to 18% (experimental group) (α=0.05, power=80%, plus 20% dropout).",[65,66,67,68],"Elderly Patients","Laparoscopic Surgery","Postoperative Hypoxemia","Capnography","NOT_YET_RECRUITING","2026-06-16",{"date":72,"type":73},"2026-06-17","ACTUAL",{"date":75,"type":59},"2026-07-01",{"date":77,"type":59},"2028-10-01",{"name":44,"class":6}]