[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100274401":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":30,"responsibleParty":47,"collaborators":19,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":19,"eligibilityCriteria":56,"healthyVolunteers":52,"sex":57,"minAge":19,"maxAge":58,"enrollmentInfo":59,"targetDuration":19,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":19,"overallStatus":32,"whyStopped":19,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"Boston Children's Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Autologous mitochondria injection","EXPERIMENTAL","All subjects will have autologous mitochondria injected into ischemic areas of the myocardium (via injection or infusion).",[13],"Other: autologous mitochondria transplantation",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"autologous mitochondria transplantation","Autologous mitochondria obtained from the subject's own skeletal muscle will be injected or infused into the ischemic myocardium",[9],null,[21],{"name":22,"affiliation":5,"role":23},"Sitaram M Emani, MD","PRINCIPAL_INVESTIGATOR",[25],{"name":26,"role":27,"phone":28,"phoneExt":19,"email":29},"Breanna Piekarski, RN, BSN","CONTACT","617-919-4457","breanna.piekarski@cardio.chboston.org",[31],{"facility":5,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"RECRUITING","Boston","Massachusetts","02115","United States","US",{"type":39,"coordinates":40},"Point",[41,42],-71.05977,42.35843,{"lat":42,"lon":41},[45,46],{"name":26,"role":27,"phone":28,"phoneExt":19,"email":29},{"name":22,"role":23,"phone":19,"phoneExt":19,"email":19},{"type":23,"investigatorFullName":48,"investigatorTitle":49,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"Sitaram Emani","Principal Investigator","100274401","transplantation-of-autologously-derived-mitochondria-following-ischemia-100274401",false,"NCT02851758","Transplantation of Autologously Derived Mitochondria Following Ischemia","Transplantation of Autologously Derived Mitochondria for Protection Against Ischemia-reperfusion Injury Following Ischemia in Subjects on ECMO Support","Inclusion Criteria:\n\n* Pediatric cardiology patients under the age of 18 on ECMO\n* concerns for ischemic injury on the Cardiac Intensive Care Unit\n\nExclusion Criteria:\n\n* Known mitochondria disorders","ALL","17 Years",{"count":60,"type":61},16,"ESTIMATED","INTERVENTIONAL",[64],"NA","The investigators propose a robust therapeutic intervention to ameliorate myocardial ischemia\u002F reperfusion injury and significantly decrease morbidity and mortality in patients requiring extracorporeal membrane oxygenation (ECMO), by direct injection of autogeneic mitochondria into the ischemic myocardium.",[67],"Extracorporeal Membrane Oxygenation Complication","2025-12-30",{"date":70,"type":71},"2026-01-05","ACTUAL",{"date":73,"type":71},"2017-08-02",{"date":75,"type":61},"2027-06",{"name":5,"class":6},1]