[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100630688":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":25,"locations":18,"responsibleParty":31,"collaborators":18,"id":33,"slug":34,"hasResults":35,"nctId":36,"briefTitle":37,"officialTitle":38,"acronym":18,"eligibilityCriteria":39,"healthyVolunteers":35,"sex":40,"minAge":41,"maxAge":18,"enrollmentInfo":42,"targetDuration":18,"studyType":45,"phases":46,"briefSummary":48,"conditions":49,"keywords":18,"overallStatus":51,"whyStopped":18,"lastUpdateSubmitDate":52,"lastUpdatePostDateStruct":53,"startDateStruct":56,"completionDateStruct":58,"leadSponsor":60,"locationsCount":18},{"fullName":5,"class":6},"Beijing Chao Yang Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Transpulmonary pressure group","EXPERIMENTAL","The overall concept of this group is to individualize PEEP. After enrollment, all patients underwent placement of an gastric tube for esophageal pressure monitoring.Tidal volume is adjusted to achieve a target tidal volume of 6 mL\u002Fkg predicted body weight (PBW) while controlling end-inspiratory transpulmonary pressure ≤ 20 cmH₂O. PEEP is adjusted to maintain end-expiratory transpulmonary pressure between 0 and 2 cmH₂O. FiO₂ is titrated to keep the patient's SpO₂ at 90%-95%. Respiratory rate is adjusted to maintain pH between 7.30 and 7.45 and PaCO₂ ≤ 60 mmHg.\n\nIf end-inspiratory transpulmonary pressure exceeds 20 cmH₂O, tidal volume may be reduced to 4 mL\u002Fkg PBW as necessary. For patients with severe dyspnea or respiratory acidosis, tidal volume may be increased up to 8 mL\u002Fkg PBW provided that end-inspiratory transpulmonary pressure remains ≤ 20 cmH₂O.",[13],"Device: Transpulmonary pressure guided mechanical ventilation strategy",{"label":15,"type":16,"description":17,"interventionNames":18},"Control group","NO_INTERVENTION","In this group, PEEP was titrated using the low PEEP:FiO₂ table method. Volume-assist control (V-A\u002FC) ventilation was adopted, with tidal volume maintained at approximately 6 mL\u002Fkg predicted body weight (PBW) and plateau pressure controlled at ≤ 30 cmH₂O. PEEP was adjusted to maintain the oxygenation target of SpO₂ 90%-95% while using the lowest possible PEEP:FiO₂ combination in the table. Respiratory rate was adjusted to maintain pH between 7.30 and 7.45 and PaCO₂ ≤ 60 mmHg.\n\nEsophageal pressure monitoring was simultaneously performed in this group to calculate and record end-inspiratory and end-expiratory transpulmonary pressures; however, ventilator parameters were not adjusted based on these measurements, and crossover to the transpulmonary pressure (Ptp) group was not permitted.\n\nIf plateau pressure exceeded 30 cmH₂O, tidal volume could be reduced to 4 mL\u002Fkg PBW as necessary. For patients with severe dyspnea or respiratory acidosis, tidal volume could be increased up to 8 mL\u002Fkg PBW",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"DEVICE","Transpulmonary pressure guided mechanical ventilation strategy","Tidal volume is adjusted to achieve a target tidal volume of 6 mL\u002Fkg predicted body weight (PBW) while controlling end-inspiratory transpulmonary pressure ≤ 20 cmH₂O. PEEP is adjusted to maintain end-expiratory transpulmonary pressure between 0 and 2 cmH₂O.\n\nIn control group, PEEP was titrated using the low PEEP:FiO₂ table method.",[9],[26],{"name":27,"role":28,"phone":29,"phoneExt":18,"email":30},"Xiao Tang, MD","CONTACT","86013811089795","tangxiao0928@163.com",{"type":32,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100630688","transpulmonary-pressure-guided-mechanical-ventilation-strategy-in-right-ventricular-protection-in-patients-with-ards-100630688",false,"NCT07490925","Transpulmonary Pressure-guided Mechanical Ventilation Strategy in Right Ventricular Protection in Patients With ARDS","Application of Transpulmonary Pressure-guided Mechanical Ventilation Strategy in Right Ventricular Protection in Patients With Acute Respiratory Distress Syndrome Caused by Pneumonia","Inclusion Criteria:\n\n1. Age ≥ 18 years old\n2. ARDS caused by pneumonia (New Global Definition of ARDS)\n3. PaO2\u002FFiO2≤200mmHg\n4. Received invasive mechanical ventilation\n5. Sign the informed consent form\n\nExclusion Criteria:\n\n1. Invasive mechanical ventilation duration \\> 48 hours\n2. History of pulmonary hypertension caused by various reasons\n3. Severe arrhythmia\n4. BMI\\>30kg\u002Fm2\n5. Contraindications to inserting an esophageal catheter (including recent esophageal injury or surgery, severe coagulopathy (platelets \\\u003C 5×10⁹\u002FL or INR \\> 4)\n6. Pregnant and lactating women\n7. Lung transplant recipient\n8. High-risk factors for increased intracranial pressure (including intracranial hemorrhage, cerebral contusion, cerebral edema, intracranial space-occupying lesions, etc.)\n9. Active air leakage in the lungs (pneumothorax, mediastinal emphysema, bronchopleural fistula, air leakage from closed thoracic drainage tubes, etc.)\n10. Neuromuscular disease\n11. Already received salvage measures (iNO, ECMO, prone position, high-frequency oscillatory ventilation)\n12. Severe liver failure\n13. Participated in other ARDS-related studies within 30 days","ALL","18 Years",{"count":43,"type":44},180,"ESTIMATED","INTERVENTIONAL",[47],"NA","To verify whether the transpulmonary pressure-guided mechanical ventilation strategy can reduce right ventricular involvement, especially the incidence of acute cor pulmonale (ACP), in patients with moderate to severe ARDS induced by pneumonia compared with the currently widely used right ventricular protective mechanical ventilation strategy.",[50],"ARDS (Moderate or Severe)","NOT_YET_RECRUITING","2026-03-22",{"date":54,"type":55},"2026-03-24","ACTUAL",{"date":57,"type":44},"2026-04-01",{"date":59,"type":44},"2028-12-31",{"name":5,"class":6}]