[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100580485":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":57,"collaborators":26,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":62,"sex":68,"minAge":69,"maxAge":26,"enrollmentInfo":70,"targetDuration":26,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":26,"overallStatus":40,"whyStopped":26,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Rabin Medical Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"TAP Block Group","EXPERIMENTAL","After anesthesia induction and before surgical incision, the anesthesiologist will perform an ultrasound-guided (Venue GO, GE Healthcare, USA) single-shot TAP block in the triangle of Petit with 20 mL 0.25% bupivacaine and 2.5 µg mL-1 of epinephrine on each side.",[13],"Procedure: Transversus abdominis plane (TAP) block",{"label":15,"type":16,"description":17,"interventionNames":18},"Wound Infiltration Group","ACTIVE_COMPARATOR","Following surgery conclusion and before awakening from anesthesia, the surgeons will inject 40 mL of 0.25% bupivacaine and 2.5 µg mL-1 of epinephrine at the wound sites.",[19],"Procedure: Wound infiltration",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Transversus abdominis plane (TAP) block","A regional anesthesia technique in which a local anesthetic is injected into the transversus abdominis plane under ultrasound guidance to provide postoperative analgesia.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Wound infiltration","A local anesthetic technique where bupivacaine with epinephrine is injected directly into the surgical wound sites to provide postoperative analgesia.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Karam Azem, MD","CONTACT","+972 50 470 5001","dr.azem.k@gmail.com",[38],{"facility":39,"status":40,"city":41,"state":26,"zip":26,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Rabin Medical Center, Beilinson Hospital","RECRUITING","Petah Tikva","Israel","IL",{"type":45,"coordinates":46},"Point",[47,48],34.88747,32.08707,{"lat":48,"lon":47},[51,55],{"name":52,"role":34,"phone":53,"phoneExt":26,"email":54},"Binyamin Eisen, PhD","+972 52 311 5304","binyae@gmail.com",{"name":33,"role":56,"phone":26,"phoneExt":26,"email":26},"PRINCIPAL_INVESTIGATOR",{"type":56,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"karam azem","Attending Anesthesiologist","100580485","transversus-abdominis-plane-block-versus-wound-infiltration-for-pulmonary-function-preservation-following-laparoscopic-living-donor-nephrectomy-100580485",false,"NCT06837909","Transversus Abdominis Plane Block Versus Wound Infiltration for Pulmonary Function Preservation Following Laparoscopic Living Donor Nephrectomy","Transversus Abdominis Plane Block Versus Wound Infiltration for Pulmonary Function Preservation Following Laparoscopic Living Donor Nephrectomy (The TAPWIN Trial): A Double-Blind Randomized Controlled Trial","TAPWIN","Inclusion Criteria:\n\n* Patients who are scheduled to undergo elective LLDN.\n* Age above 18 years.\n* Body Mass Index (BMI) above 20 and below 40 kg m-2.\n* Eligible to sign informed consent.\n\nExclusion Criteria:\n\n* Open or hand-assisted surgery.\n* Known cardiac or pulmonary disease.\n* Preoperative chronic pain (i.e., fibromyalgia, chronic neuropathic pain).\n* Contraindication for regional analgesia (i.e., known allergy to LA, skin lesions in the injection site).\n* Known allergy to one or more of the components of multimodal analgesia (i.e., opioids, paracetamol, tramadol, dipyrone).\n* Preexisting severe pulmonary disease (i.e., an obstructive lung disease with a forced expiratory volume in the first second \\[FEV1\\] below 49%, restrictive lung disease with a forced vital capacity \\[FVC\\] below 49%, pulmonary hypertension).\n\nDiscontinuing criteria:\n\nParticipants will be excluded from the analysis if they:\n\n* Experience intraoperative bleeding requiring transfusion of more than three units of blood products.\n* Experience hemodynamic instability requiring postoperative vasopressor or inotropic support.\n* Require conversion to open surgery.\n* Require mechanical ventilation after being transferred from the OR to the PACU.","ALL","18 Years",{"count":71,"type":72},80,"ESTIMATED","INTERVENTIONAL",[75],"NA","This study compares two pain control techniques in patients undergoing laparoscopic kidney donation surgery: transversus abdominis plane (TAP) block versus wound infiltration with local anesthetic.\n\nPostoperative pain can impair breathing by causing patients to take shallow breaths to avoid discomfort. This study will evaluate which technique better preserves lung function, specifically peak expiratory flow (PEF), after surgery.\n\nEighty patients will be randomly assigned to receive either a TAP block (injection of local anesthetic into the abdominal wall muscles before surgery) or wound infiltration (injection of local anesthetic at the incision sites at the end of surgery). Both patients and the staff measuring outcomes will be blinded to group assignment.\n\nThe primary outcome is the percentage change in PEF from before surgery to discharge from the recovery room. Secondary outcomes include pain scores, opioid use, breathing complications, and length of hospital stay.",[78],"Postoperative Pain","2026-01-05",{"date":81,"type":82},"2026-01-07","ACTUAL",{"date":84,"type":82},"2026-01-01",{"date":86,"type":72},"2027-02-01",{"name":5,"class":6},1]