[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100591042":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":35,"centralContacts":39,"locations":46,"responsibleParty":70,"collaborators":74,"id":80,"slug":81,"hasResults":82,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":28,"eligibilityCriteria":86,"healthyVolunteers":82,"sex":87,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":44,"studyType":93,"phases":94,"briefSummary":96,"conditions":97,"keywords":103,"overallStatus":49,"whyStopped":44,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":120},{"fullName":5,"class":6},"Panteion University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention Group (TF-CBT)","EXPERIMENTAL","Participants in this arm will receive a structured therapeutic protocol based on trauma-focused cognitive behavioral therapy (TF-CBT), delivered over 12 weekly or bi-weekly sessions by trained psychologists in accommodation centers and Supported Independent Living (SIL) programs across Greece. The intervention includes psychoeducation, relaxation techniques, affective modulation, cognitive restructuring, development of a trauma narrative and trauma processing, in vivo exposure, and strategies to enhance safety and future planning. The program is specifically adapted for unaccompanied asylum-seeking minors (UAMs) presenting with symptoms of PTSD.",[13],"Behavioral: Trauma - Focused Cognitive Behavioral Therapy",{"label":15,"type":16,"description":17,"interventionNames":18},"Control group (TAU)","ACTIVE_COMPARATOR","Participants in this arm will receive the standard support services (Treatment as Usual) provided in the accommodation centers and Supported Independent Living (SIL) programs, including routine clinical management and general psychological support, without engagement in a structured therapeutic framework or participation in the trauma-focused intervention. Access to the regular psychosocial services available to all residents will remain unchanged.",[19],"Behavioral: Treatment as Usual (TAU)",[21,29],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","Trauma - Focused Cognitive Behavioral Therapy","TF-CBT is a comprehensive, evidence-based, short-term therapeutic protocol aimed at reducing trauma-related symptoms in children and adolescents aged 3-18. The protocol consists of 12 double sessions conducted with both the child and their caregiver. Developed for children who have experienced sexual abuse and multiple traumas, TF-CBT has since been successfully applied to a variety of traumatic experiences. Core components of the protocol include psychoeducation, relaxation techniques, emotional regulation, cognitive processing, trauma narrative, in vivo exposure, conjoint child\u002Fcaregiver sessions, and safety planning. The intervention is culturally informed and flexible to meet individual needs. Adjustments have been made in the context of unaccompanied minors (UAMs), where caregiver involvement is not feasible, due to specific circumstances in accommodation centers and Supportin Greece.",[9],[27,28],"Trauma-Focused CBT","TF-CBT",{"type":22,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"Treatment as Usual (TAU)","The Treatment as Usual (TAU) approach involves routine clinical management and psychological support, without the use of a structured therapeutic framework. This intervention consists of general, non-specific support provided by clinical staff, including informal counseling and monitoring of the child's psychological well-being. Unlike more structured therapeutic protocols, TAU does not follow a predefined set of interventions or techniques, allowing for a flexible and individualized approach, though lacking the formal therapeutic focus of interventions like TF-CBT.",[15],[34],"TAU",[36],{"name":37,"affiliation":5,"role":38},"Vasiliki Yotsidi, PhD","STUDY_CHAIR",[40],{"name":41,"role":42,"phone":43,"phoneExt":44,"email":45},"Theodora Anastasiou, PhD candidate","CONTACT","+306942883681",null,"theodanastasiou@gmail.com",[47],{"facility":48,"status":49,"city":50,"state":44,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"General Secretariat for Vulnerable Persons and Institutional Protection, Ministry of Migration and Asylum","RECRUITING","Athens","182 33","Greece","GR",{"type":55,"coordinates":56},"Point",[57,58],23.72784,37.98376,{"lat":58,"lon":57},[61,64,68],{"name":62,"role":42,"phone":63,"phoneExt":44,"email":45},"Theodora Anastasiou, PhD Candidate","+ 30 6942883681",{"name":65,"role":42,"phone":66,"phoneExt":44,"email":67},"Assistant Professon of Clinical Psychology","+30 6937103609","v.yiotsidi@panteion.gr",{"name":41,"role":69,"phone":44,"phoneExt":44,"email":44},"PRINCIPAL_INVESTIGATOR",{"type":71,"investigatorFullName":72,"investigatorTitle":73,"investigatorAffiliation":5,"oldNameTitle":44,"oldOrganization":44},"SPONSOR_INVESTIGATOR","Theodora Anastasiou","PhD Candidate in Clinical Psychology, Panteion University",[75,78],{"name":76,"class":77},"Greek Ministry of Migration and Asylum","UNKNOWN",{"name":79,"class":6},"SOS Children's Villages","100591042","trauma-focused-cognitive-behavioral-therapy-in-unaccompanied-refugee-minors-with-ptsd-in-greece-an-rct-100591042",false,"NCT06975280","Trauma-Focused Cognitive Behavioral Therapy in Unaccompanied Refugee Minors With PTSD in Greece: An RCT","Implementation, Cultural Adaptation, and Efficacy Evaluation of Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) for Unaccompanied Refugee Minors in Greece","Inclusion Criteria:\n\n* Be unaccompanied upon arrival in Greece and aged between 15-18 years old.\n* Being diagnosed with PTSD based on DSM-5 criteria. Young refugees with post-traumatic stress symptoms (PTSS), as delineated by high or moderate trauma-related distress in the Child and Adolescent Trauma Screen (CATS), will also be eligible to participate in the study.\n* Reside in an accommodation center or SIL program for UAMs in Greece.\n* Have a stable living arrangement for at least 2-3 weeks prior to the intervention.\n* Not be expected to relocate within the 2-3 months following the start of the intervention.\n\nExclusion Criteria:\n\n* a diagnosed intellectual disability (IQ \\\u003C 70) or another developmental disorder\n* acute suicidality or life-threatening self-harm behavior\n* significant risk of harm to others\n* comorbidity with bipolar disorder or a psychotic disorder\n* substance abuse.","ALL","15 Years","18 Years",{"count":91,"type":92},60,"ESTIMATED","INTERVENTIONAL",[95],"NA","This single-blinded, multicentered, randomized controlled trial aims to evaluate the effectiveness of Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) compared to Treatment-as-Usual (TAU) in reducing post-traumatic stress symptoms among unaccompanied refugee minors (UAMs) residing in accommodation centers and Supported Independent Living (SIL) programs in Greece. Participants aged 15-18 will be randomly assigned to either a TF-CBT intervention group or a TAU control group. The intervention will be delivered by trained psychologists under supervision and culturally adapted to the Greek refugee context. Assessments will occur at baseline, post-intervention, and three months later, using standardized psychometric tools. Secondary outcomes include changes in comorbid psychiatric symptoms (depression, anxiety, somatic symptoms), emotional and behavioral difficulties, and quality of life. The study also investigates potential moderators of treatment response such as age, gender, trauma history, and psychiatric comorbidity.",[98,99,100,101,102],"Post-Traumatic Stress Disorder (PTSD)","Depressive Symptoms","Anxiety Symptoms","Somatic Symptoms","Emotional and Behavioral Difficulties",[104,105,106,28,107,108,109,110],"Unaccompanied minors","Refugee adolescents","Trauma-Focused Cognitive Behavioral Therapy","PTSD","Depression","Anxiety","Child trauma","2025-05-08",{"date":113,"type":114},"2025-05-16","ACTUAL",{"date":116,"type":114},"2023-04-13",{"date":118,"type":92},"2026-02",{"name":72,"class":6},1]