[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100566716":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":31,"centralContacts":39,"locations":48,"responsibleParty":68,"collaborators":72,"id":76,"slug":77,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":31,"eligibilityCriteria":82,"healthyVolunteers":83,"sex":84,"minAge":85,"maxAge":86,"enrollmentInfo":87,"targetDuration":31,"studyType":90,"phases":91,"briefSummary":93,"conditions":94,"keywords":97,"overallStatus":51,"whyStopped":31,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":111},{"fullName":5,"class":6},"Guangzhou Psychiatric Hospital","OTHER_GOV",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Left DLPFC stimulation group","EXPERIMENTAL","The tDCS parameters were set to a current of 2mA for a single session lasting 20 minutes. Based on the EEG 10-20 international system, the positive electrode was placed at position F3, and the negative electrode was placed in the right supraorbital area\u002FFP2 (e.g., Dubreuil-Vall et al., 2021, Biol Psychiatry: CNNI)",[13],"Device: Transcranial direct current stimulation (tDCS) on the Left DLPFC",{"label":15,"type":10,"description":16,"interventionNames":17},"Right VLPFC stimulation group","The tDCS parameters were set to a current of 2mA for a single session lasting 20 minutes. Based on the EEG 10-20 international system, the positive electrode for stimulating the right VLPFC was placed at position F6, while the negative electrode was placed in the left supraorbital area\u002FFP1 (e.g., He et al., 2020, Psychol Med).",[18],"Device: Transcranial direct current stimulation (tDCS) on the right VLPFC",{"label":20,"type":21,"description":22,"interventionNames":23},"Sham stimulation group","SHAM_COMPARATOR","In the sham stimulation group, the electrode positions were randomized to match those of the rVLPFC or lDLPFC groups, but the stimulation only lasted for the first 30 seconds.",[24],"Device: Sham stimulation group",[26,32,36],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"DEVICE","Transcranial direct current stimulation (tDCS) on the Left DLPFC","The tDCS parameters were set to a current of 2mA for a single session lasting 20 minutes. For stimulating the lDLPFC, the positive electrode was placed at position F3, and the negative electrode was placed in the right supraorbital area\u002FFP2 (e.g., Dubreuil-Vall et al., 2021, Biol Psychiatry: CNNI).",[9],null,{"type":27,"name":33,"description":34,"armGroupLabels":35,"otherNames":31},"Transcranial direct current stimulation (tDCS) on the right VLPFC","The tDCS parameters were set to a current of 2mA for a single session lasting 20 minutes. Based on the EEG 10-20 international system, the positive electrode for stimulating the rVLPFC was placed at position F6, while the negative electrode was placed in the left supraorbital area\u002FFP1 (e.g., He et al., 2020, Psychol Med)",[15],{"type":27,"name":20,"description":37,"armGroupLabels":38,"otherNames":31},"The electrode positions were randomized to match those of the rVLPFC or lDLPFC groups, but the stimulation only lasted for the first 30 seconds.",[20],[40,45],{"name":41,"role":42,"phone":43,"phoneExt":31,"email":44},"Kangguang Lin, PhD; MD","CONTACT","8613560360144","klin@gzhmu.edu.cn",{"name":46,"role":42,"phone":31,"phoneExt":31,"email":47},"Robin Shao, PhD","James0828@hotmail.com",[49],{"facility":50,"status":51,"city":52,"state":53,"zip":54,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"Guangzhou Brain Hospital","RECRUITING","Guangzhou","Guangdong","510370","China","CN",{"type":58,"coordinates":59},"Point",[60,61],113.25,23.11667,{"lat":61,"lon":60},[64],{"name":65,"role":42,"phone":66,"phoneExt":31,"email":67},"Kangguang Lin, Ph.D; MD","8602081268219","linkangguang@163.com",{"type":69,"investigatorFullName":70,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"PRINCIPAL_INVESTIGATOR","Kangguang Lin","Director of the Department of Affective disorders",[73],{"name":74,"class":75},"The University of Hong Kong","OTHER","100566716","treating-loneliness-in-the-older-adult-with-depression-with-tdcs-100566716",false,"NCT06658795","Treating Loneliness In The Older Adult With Depression With tDCS","Effects of Transcranial Direct Current Stimulation on Loneliness in Older Adults With Depression: A Randomized Controlled Trial","Inclusion Criteria:\n\n* High loneliness (UCLA Loneliness Scale \\> 43).\n* Diagnosis of major depressive disorder confirmed by the Structured Clinical Interview for DSM-5 Disorders.\n* absence of suicidal ideation (Hamilton Depression Scale item 3 score ≤ 1).\n\nExclusion Criteria:\n\n* Severe neurological diseases.\n* Bipolar disorder, schizophrenia, addiction, or impulse control disorders.\n* Contraindications for tDCS or MRI (e.g., metal implants).\n* Presence of suicidal ideation.",true,"ALL","60 Years","80 Years",{"count":88,"type":89},180,"ESTIMATED","INTERVENTIONAL",[92],"NA","High loneliness is prevalent among older adults and is a significant risk factor for major depression and low recovery rates in patients. Current interventions for loneliness are limited. Previous research has demonstrated a link between loneliness, negative social emotions, and reduced resting-state functional connectivity in the lateral prefrontal cortex (LPFC) and the default mode network (DMN). Transcranial direct current stimulation (tDCS) has shown promise in enhancing emotional regulation and connectivity, potentially alleviating loneliness in older adults with depression.",[95,96],"Major Depressive Disorder","Loneliness",[98,99,100,101],"Randomization Controlled Trial","Transcranial Direct Current Stimulation","Depression","loneliness","2024-10-23",{"date":104,"type":105},"2024-10-26","ACTUAL",{"date":107,"type":89},"2024-10-29",{"date":109,"type":89},"2026-12-30",{"name":5,"class":6},1]