[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100556108":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":20,"responsibleParty":29,"collaborators":33,"id":36,"slug":37,"hasResults":38,"nctId":39,"briefTitle":40,"officialTitle":40,"acronym":41,"eligibilityCriteria":42,"healthyVolunteers":38,"sex":43,"minAge":44,"maxAge":45,"enrollmentInfo":46,"targetDuration":20,"studyType":49,"phases":50,"briefSummary":52,"conditions":53,"keywords":60,"overallStatus":64,"whyStopped":20,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":20},{"fullName":5,"class":6},"University of Lisbon","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Traumatic and overuse exercise-related injuries","EXPERIMENTAL","There is no registry of any clinically relevant adverse or unintended event associated with this kind of intervention. Nevertheless, adolescents with severe obesity may be at higher risk of both traumatic and overuse exercise-related injuries. A specific insurance for special risk participants, covering exercise-related injuries and dead (Appendix 1), will be activated in case of any adverse or unintended event during or as consequence of the exercise sessions. The impact of that specific event will be additionally analyzed and reported by the health professionals.",[13],"Behavioral: Treatment and handling obesity-related comorbidities in adolescents through exercise",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"BEHAVIORAL","Treatment and handling obesity-related comorbidities in adolescents through exercise","Tailor-made, one-to-one, physical exercise program",[9],null,[22,27],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Helena Fonseca, Ph.D","CONTACT","966329031","helenaregalofonseca@gmail.com",{"name":28,"role":24,"phone":20,"phoneExt":20,"email":26},"Helena Fonseca Fonseca, Ph.D",{"type":30,"investigatorFullName":31,"investigatorTitle":32,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"PRINCIPAL_INVESTIGATOR","A. Videira-Silva","Professor",[34],{"name":35,"class":6},"Lusofona University","100556108","treatment-and-handling-severe-obesity-related-comorbidities-in-adolescents-through-exercise-100556108",false,"NCT06520800","Treatment and Handling Severe Obesity-Related Comorbidities in Adolescents Through Exercise","THOR-X","Inclusion Criteria:\n\n* adolescents aged 13 to 18 years;\n* of any gender (including transgender adolescents);\n* with severe obesity (≥3.0 BMI z-score) \\[24\\];\n* with any obesity-related comorbidity (e.g., hypertension, IR or DMT2, dyslipidemia, eating disorders, depression\u002Fanxiety);\n* at least 6 months of follow-up at the Pediatric Obesity Clinic (HSM, CHULN) at the time of recruitment;\n* living in Lisbon area;\n* informed consent\u002Fassent signature.\n\nExclusion Criteria:\n\n* major or unstable clinical conditions (other than obesity or its related comorbidities);\n* inability to perform regular PA;\n* pregnancy;\n* mental disorders;\n* smoking habits;\n* being involved in another weight loss program.","ALL","13 Years","18 Years",{"count":47,"type":48},24,"ESTIMATED","INTERVENTIONAL",[51],"NA","The main objective of this project is to analyze the effect of a tailor-made, one-to-one, exercise program (aiming to treat and handle obesity-related comorbidities in adolescents with severe obesity at high risk of cardiovascular disease development) on BMI z-score, specific comorbidities, and other health-related indicators.\n\nThis project will further allow to analyze the long-term impact of the exercise program not only on clinical parameters, but also on the interaction with drug-treatment, health-related behaviors, and quality of life, further contributing to the understanding of the individual characteristics associated with a positive exercise response and frequency.\n\nThe secondary objective of the THOR-X project is to build an educational toolkit, based on project results and relevant literature, addressed to health and exercise professionals, in order to improve management of adolescents with obesity, in particular those with severe obesity.",[54,55,56,57,58,59],"Adolescent Obesity","Hypertension,Essential","Non-Alcoholic Fatty Liver Disease","Dyslipidemias","Metabolic Disease","Metabolic Syndrome",[54,61,62,63],"Obesity treatment","Physical activity","Exercise","NOT_YET_RECRUITING","2024-07-25",{"date":67,"type":68},"2024-07-29","ACTUAL",{"date":70,"type":48},"2025-01",{"date":72,"type":48},"2028-12",{"name":5,"class":6}]