[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100612932":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":28,"locations":34,"responsibleParty":55,"collaborators":24,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":24,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":24,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":24,"overallStatus":37,"whyStopped":24,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Can Tho University of Medicine and Pharmacy","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Bismuth quadruple therapy","EXPERIMENTAL","Patients in this arm will receive PPI, Amoxicillin, Metronidazole, and Bismuth for 14 days, with doses adjusted according to weight and age.",[13],"Drug: Bismuth quadruple therapy",{"label":15,"type":10,"description":16,"interventionNames":17},"Triple therapy with PPI + Amoxicillin + Metronidazole","Patients in this arm will receive PPI, Amoxicillin, Metronidazole for 14 days, with doses adjusted according to weight and age.",[18],"Drug: Triple therapy with PPI + Amoxicillin + Metronidazole",[20,25],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"DRUG","A 14-day regimen including proton pump inhibitor (PPI; esomeprazole \\[Nexium MUPS\\]), bismuth subcitrate (or bismuth subsalicylate), amoxicillin, and metronidazole. All drug doses are adjusted according to the participant's age and weight.",[9],null,{"type":21,"name":15,"description":26,"armGroupLabels":27,"otherNames":24},"A 14-day regimen including proton pump inhibitor (PPI; esomeprazole \\[Nexium MUPS\\]), amoxicillin, and metronidazole.\n\nAll drug doses are adjusted according to the participant's age and weight.",[15],[29],{"name":30,"role":31,"phone":32,"phoneExt":24,"email":33},"Trang Thuy Mai, MD","CONTACT","+84 838 857 890","maithuytrang2000@gmail.com",[35],{"facility":36,"status":37,"city":38,"state":24,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Can Tho Children's Hospital","RECRUITING","Can Tho","900000","Vietnam","VN",{"type":43,"coordinates":44},"Point",[45,46],105.78825,10.03711,{"lat":46,"lon":45},[49,53],{"name":50,"role":31,"phone":51,"phoneExt":24,"email":52},"Loan Thi Thuy Le, MD, PhD","+84 914 375 231","lttloan@ctump.edu.vn",{"name":30,"role":54,"phone":24,"phoneExt":24,"email":24},"PRINCIPAL_INVESTIGATOR",{"type":54,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Mai Thùy Trang","Doctor","100612932","treatment-efficacy-of-regimens-with-and-without-bismuth-in-children-with-helicobacter-pylori-associated-peptic-ulcer-disease-100612932",false,"NCT07260006","Treatment Efficacy of Regimens With and Without Bismuth in Children With Helicobacter Pylori-Associated Peptic Ulcer Disease","A Study on the Treatment Efficacy of Regimens With and Without Bismuth in Children With Helicobacter Pylori-Associated Peptic Ulcer Disease","Inclusion Criteria:\n\n* Diagnosed with gastritis or peptic ulcer disease by upper gastrointestinal endoscopy or histopathology.\n* Meets diagnostic criteria for Helicobacter pylori infection.\n* Parent or legal guardian provides consent for the child to participate in the study.\n\nExclusion Criteria:\n\n* Allergic to any of the medications in the treatment regimen.\n* Use of antibiotics or bismuth within the past 4 weeks, or use of antacids, H2-receptor antagonists, or proton pump inhibitors within the past 2 weeks.\n* Failure to return for follow-up visits after treatment.","ALL","5 Years","15 Years",{"count":69,"type":70},80,"ESTIMATED","INTERVENTIONAL",[73],"NA","The goal of this clinical trial is to learn if including bismuth in the treatment helps heal stomach and duodenal ulcers caused by Helicobacter pylori (H. pylori) in children.\n\nThe main questions it aims to answer are:\n\n* Does a treatment plan with bismuth work better than a plan without bismuth to clear the infection?\n* Is the bismuth plan more cost-effective while still safe and effective?\n\nResearchers will compare two treatment groups to see which works better. Participants will:\n\n* Take one of the two assigned treatment plans (with or without bismuth) for the standard treatment duration\n* Visit the clinic for checkups and tests to confirm infection clearance and monitor side effects\n* Keep a diary of symptoms, medication use, and any side effects",[76,77],"Helicobacter Pylori Infection","Peptic Ulcer","2025-11-21",{"date":80,"type":81},"2025-12-02","ACTUAL",{"date":83,"type":81},"2024-10-01",{"date":85,"type":70},"2026-05-30",{"name":5,"class":6},1]